Výsledky vyhledávání - "Martin, Schaller"

Akademický článek

Penetration Profile of Terbinafine Compared to Amorolfine in Mycotic Human Toenails Quantified by Matrix-Assisted Laser Desorption Ionization–Fourier Transform Ion Cyclotron Resonance Imaging

Autor: Nicolas Joly-Tonetti, Raphael Legouffe, Aurore Tomezyk, Clémence Gumez, Mathieu Gaudin, David Bonnel, Martin Schaller

Publikováno v: Infectious Diseases and Therapy, Vol 13, Iss 6, Pp 1281-1290 (2024)

Abstract Introduction Amorolfine 5% lacquer is an established topical treatment for fungal infection of the nails. The success of topical therapy for onychomycosis depends on whether the permeated drug concentration in the deep nail bed is retained a

Externí odkaz: https://doaj.org/article/22f496657ce4414c826ad0828f950ae6

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Akademický článek

Penetration Profiles of Four Topical Antifungals in Mycotic Human Toenails Quantified by Matrix-Assisted Laser Desorption Ionization–Fourier Transform Ion Cyclotron Resonance Imaging

Autor: Nicolas Joly-Tonetti, Raphael Legouffe, Aurore Tomezyk, Clémence Gumez, Mathieu Gaudin, David Bonnel, Martin Schaller

Publikováno v: Infectious Diseases and Therapy, Vol 13, Iss 6, Pp 1269-1279 (2024)

Abstract Introduction Onychomycosis is a fungal infection of the nails that can be challenging to treat. Here, matrix-assisted laser desorption ionization–Fourier transform ion cyclotron resonance (MALDI-FTICR) imaging was applied to the quantitati

Externí odkaz: https://doaj.org/article/017a068c282947998a65a2f42184fd9d

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Akademický článek

Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy

Autor: Francisco Meraz-Torres, Heike Niessner, Sarah Plöger, Simon Riel, Barbara Schörg, Nicolas Casadei, Manfred Kneilling, Martin Schaller, Lukas Flatz, Boris Macek, Thomas Eigentler, Olaf Rieß, Claus Garbe, Teresa Amaral, Tobias Sinnberg

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)

Abstract Background MEK inhibitors (MEKi) were shown to be clinically insufficiently effective in patients suffering from BRAF wild-type (BRAF WT) melanoma, even if the MAPK pathway was constitutively activated due to mutations in NRAS or NF-1. Thus,

Externí odkaz: https://doaj.org/article/35307e889f494a0d91d148dbfa645149

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Akademický článek

Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors

Publikováno v: Molecular Cancer, Vol 22, Iss 1, Pp 1-18 (2023)

Abstract Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L

Externí odkaz: https://doaj.org/article/b3fa661fa2c8409a83b991ccda94efe7

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Akademický článek

Wall teichoic acid substitution with glucose governs phage susceptibility of Staphylococcus epidermidis

Autor: Christian Beck, Janes Krusche, Anna Notaro, Axel Walter, Lara Kränkel, Anneli Vollert, Regine Stemmler, Johannes Wittmann, Martin Schaller, Christoph Slavetinsky, Christoph Mayer, Cristina De Castro, Andreas Peschel

Publikováno v: mBio, Vol 15, Iss 4 (2024)

ABSTRACTThe species- and clone-specific susceptibility of Staphylococcus cells for bacteriophages is governed by the structures and glycosylation patterns of wall teichoic acid (WTA) glycopolymers. The glycosylation-dependent phage-WTA interactions i

Externí odkaz: https://doaj.org/article/00260f1e15e944578a9349b13820b6cd

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