Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Martin, Prlic"'
Autor:
Tanvi Arkatkar, Veronica Davé, Irene Cruz Talavera, Jessica B. Graham, Jessica L. Swarts, Sean M. Hughes, Timothy A. Bell, Pablo Hock, Joe Farrington, Ginger D. Shaw, Anna Kirby, Michael Fialkow, Meei-Li Huang, Keith R. Jerome, Martin T. Ferris, Florian Hladik, Joshua T. Schiffer, Martin Prlic, Jennifer M. Lund
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Mucosal infections pose a significant global health burden. Antigen-specific tissue-resident T cells are critical to maintaining barrier immunity. Previous studies in the context of systemic infection suggest that memory CD8+ T cells may also provide
Externí odkaz:
https://doaj.org/article/c1f6027d12e448b38a3cfc27c143ba2e
Autor:
Florencia A. Tettamanti Boshier, Daniel B. Reeves, Elizabeth R. Duke, David A. Swan, Martin Prlic, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss 4, Pp 100091- (2022)
The HIV reservoir is a population of 1–10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA. When antiretroviral therapy (ART) is stopped and HIV replication
Externí odkaz:
https://doaj.org/article/288b3e7c136f4bc8a6639690c4e7cf24
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/c213a3fa29474144a6e64ef4bfd66a63
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
T cell receptor (TCR) stimulation leads to the expression of the transcription factor thymocyte selection–associated high-mobility group box (TOX). Prolonged TCR signaling, such as encountered during chronic infections or in tumors, leads to sustai
Externí odkaz:
https://doaj.org/article/ae14fd422907454395a5952d0a06f023
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
T cell bystander activation is induced by systemic inflammation. Here the authors show, using mouse model systems and correlating with human vaccination data, that localized inflammation elicits bystander activation, and that CXCR3 specifically recru
Externí odkaz:
https://doaj.org/article/2da069aa679845dc876812190e0373ee
Autor:
Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christoph A. Mayer, Percy Knolle, Martin Klingenspor, Valeria Fumagalli, Matteo Iannacone, Martin Prlic, Thomas Korn, Erika L. Pearce, Thomas Höfer, Anna M. Schulz, Dietmar Zehn
Publikováno v:
Nature Immunology
Blocking pyrimidine de novo synthesis by inhibiting dihydroorotate dehydrogenase is used to treat autoimmunity and prevent expansion of rapidly dividing cell populations including activated T cells. Here we show memory T cell precursors are resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085f2909a004801c889c7b71682d6c58
https://doi.org/10.1038/s41590-023-01436-x
https://doi.org/10.1038/s41590-023-01436-x
Autor:
Jami R. Erickson, Florian Mair, Grace Bugos, Jody Martin, Aaron J. Tyznik, Margaret Nakamoto, Stefanie Mortimer, Martin Prlic
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100092- (2020)
Summary: By including oligonucleotide-labeled antibodies into high-throughput single-cell RNA-sequencing protocols, combined transcript and protein expression data can be acquired on the single-cell level. Here, we describe a protocol for the combine
Externí odkaz:
https://doaj.org/article/b4664e2be1b443d2b0d992b0be29777c
Autor:
Shamin Li, Yannick Simoni, Etienne Becht, Chiew Yee Loh, Naisi Li, Daniel Lachance, Si-Lin Koo, Teck Por Lim, Emile Kwong Wei Tan, Ronnie Mathew, Andrew Nguyen, Justin Golovato, Julia D. Berkson, Martin Prlic, Bernett Lee, Samuel S. Minot, Niranjan Nagarajan, Neelendu Dey, Daniel S.W. Tan, Iain B. Tan, Evan W. Newell
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 3, Pp 100039- (2020)
Summary: Growing evidence indicates a role for the gut microbiota in modulating anti-tumor treatment efficacy in human cancer. Here we study mucosa-associated invariant T (MAIT) cells to look for evidence of bacterial antigen recognition in human col
Externí odkaz:
https://doaj.org/article/d2eb10be4e904544bf143c99be363eef
Autor:
Florian Mair, Jami R. Erickson, Valentin Voillet, Yannick Simoni, Timothy Bi, Aaron J. Tyznik, Jody Martin, Raphael Gottardo, Evan W. Newell, Martin Prlic
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: High-throughput single-cell RNA sequencing (scRNA-seq) has become a frequently used tool to assess immune cell heterogeneity. Recently, the combined measurement of RNA and protein expression was developed, commonly known as cellular indexing
Externí odkaz:
https://doaj.org/article/0e450745aa8b49b5b9100025ab4e67ec
Autor:
Daniel B. Reeves, Elizabeth R. Duke, Sean M. Hughes, Martin Prlic, Florian Hladik, Joshua T. Schiffer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract In the era of antiretroviral therapy (ART), HIV-1 infection is no longer tantamount to early death. Yet the benefits of treatment are available only to those who can access, afford, and tolerate taking daily pills. True cure is challenged by
Externí odkaz:
https://doaj.org/article/3bd56a0f58ac4f5799ab988ad7daaffa