A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE)

Autor: European Food Safety Authority (EFSA), Kevin M. Crofton, Martin Paparella, Anna Price, Iris Mangas, Laura Martino, Andrea Terron, Antonio Hernández‐Jerez

Publikováno v: EFSA Journal, Vol 22, Iss 8, Pp n/a-n/a (2024)

Abstract The adverse outcome pathway (AOP) framework serves as a practical tool for organising scientific knowledge that can be used to infer cause–effect relationships between stressor events and toxicity outcomes in intact organisms. However, a m

Externí odkaz: https://doaj.org/article/c3b3bb85a2de473da5a703e2851b6664

OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines

Autor: Miriam N. Jacobs, Jan M. Bult, Kevin Cavanagh, Christophe Chesne, Nathalie Delrue, Jianan Fu, Emma Grange, Ingrid Langezaal, Dominika Misztela, Jenny Murray, Martin Paparella, Gilly Stoddart, Torsten Tonn, Carol Treasure, Masaaki Tsukano, Rosemary Versteegen

Publikováno v: Frontiers in Toxicology, Vol 5 (2023)

The ethical needs and concerns with use and sourcing of human materials, particularly serum, in OECD in vitro test guidelines were explored in a dedicated international workshop held in 2019. The health-related aspects of the donation procedure, incl

Externí odkaz: https://doaj.org/article/64e648c9e6894018be64557ad5a4ea22

Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens

Autor: Yusuke Oku, Federica Madia, Pierre Lau, Martin Paparella, Timothy McGovern, Mirjam Luijten, Miriam N. Jacobs

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 21, p 12718 (2022)

With recent rapid advancement of methodological tools, mechanistic understanding of biological processes leading to carcinogenesis is expanding. New approach methodologies such as transcriptomics can inform on non-genotoxic mechanisms of chemical car

Externí odkaz: https://doaj.org/article/033f56b2441f4199aaaf0ffecffd7ef8

Big Question to Developing Solutions: A Decade of Progress in the Development of Aquatic New Approach Methodologies from 2012 to 2022

Autor: Laura M. Langan, Martin Paparella, Natalie Burden, Lisa Constantine, Luigi Margiotta‐Casaluci, Thomas H. Miller, S. Jannicke Moe, Stewart F. Owen, Alexandra Schaffert, Tiina Sikanen

Data Availability statement: No data has been generated in the writing of this article. However, all articles which have been cited or influenced the summarization outlined are provided in supplementary material on a section-by-section basis. Support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb55e7d7323dc064ec8026449f991fe1
https://bura.brunel.ac.uk/handle/2438/26151

Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

Autor: Marco Corvaro, Paule Vasseur, Monica Vaccari, Annamaria Colacci, Federica Madia, Martin Paparella, Akiyoshi Nishikawa, Nathalie Delrue, Kumiko Ogawa, Norman Ertych, Raffaella Corvi, Miriam N. Jacobs, Kiyomi Ohmori, M. Cecilia Aguila, Mirjam Luijten, Daniel Desaulniers, Anoop Kumar Sharma, Abigail Jacobs

Publikováno v: Jacobs, M N, Colacci, A, Corvi, R, Vaccari, M, Aguila, M C, Corvaro, M, Delrue, N, Desaulniers, D, Ertych, N, Jacobs, A, Luijten, M, Madia, F, Nishikawa, A, Ogawa, K, Ohmori, K, Paparella, M, Sharma, A K & Vasseur, P 2020, ' Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens ', Archives of Toxicology, vol. 94, no. 8, pp. 2899-2923 . https://doi.org/10.1007/s00204-020-02784-5
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, 94 (8), pp.2899-2923. ⟨10.1007/s00204-020-02784-5⟩

While regulatory requirements for carcinogenicity testing of chemicals vary according to product sector and regulatory jurisdiction, the standard approach starts with a battery of genotoxicity tests (which include mutagenicity assays). If any of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc056687031b8806f8cb63d08ebfaba
https://doi.org/10.1007/s00204-020-02784-5