Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine.

Autor: Christian Ruiz, Stefan Kustermann, Elina Pietilae, Tatjana Vlajnic, Betty Baschiera, Leila Arabi, Thomas Lorber, Martin Oeggerli, Spasenija Savic, Ellen Obermann, Thomas Singer, Sacha I Rothschild, Alfred Zippelius, Adrian B Roth, Lukas Bubendorf

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160807 (2016)

The use of patients' own cancer cells for in vitro selection of the most promising treatment is an attractive concept in personalized medicine. Human carcinoma cells from malignant pleural effusions (MPEs) are suited for this purpose since they have

Externí odkaz: https://doaj.org/article/978afa43d8174d57b35ed16f87948089

High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth

Autor: Silvia Gluderer, Lukas Bubendorf, Susanna Stürm, Hugo Stocker, Mariacarla Andreozzi, Luigi Terracciano, George N. Thalmann, Edward P. Gelmann, Thomas C. Gasser, Martin Oeggerli, Christian Ruiz, Tobias Zellweger, Pasi A. Koivisto, Markus Germann, Andrew G. Glass, Marco G. Cecchini, Alexander Bachmann, Stephen Wyler, Cyrill A. Rentsch, Heikki Helin

Publikováno v: The Prostate. 72:1678-1687

We recently established the rationale that NRBP1 (nuclear receptor binding protein 1) has a potential growth-promoting role in cell biology. NRBP1 interacts directly with TSC-22, a potential tumor suppressor gene that is differently expressed in pros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd1106833b4ab071bc3db751eddf1d63
https://doi.org/10.1002/pros.22521

Amplification and overexpression of vinculin are associated with increased tumour cell proliferation and progression in advanced prostate cancer

Autor: David R Holz, Tobias Zellweger, Martin Oeggerli, Spyro Mousses, Lukas Bubendorf, Heikki Helin, Pasi A. Koivisto, Irma M. Gonzales, Jeff Kiefer, Michael T. Barrett, Sandra Schneider, David O. Azorsa, Christian Ruiz, Alexander Bachmann

Publikováno v: The Journal of Pathology. 223:543-552

Androgen withdrawal is the standard treatment for advanced prostate cancer. Although this therapy is initially effective, nearly all prostate cancers become refractory to it. Approximately 15% of these castration-resistant prostate cancers harbour a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d030b5a8ea06d729f7a11877ab05edfb
https://doi.org/10.1002/path.2828

Role of KCNMA1 in breast cancer

Autor: Matthias Sausbier, Inti Zlobec, Karl Kunzelmann, Lukas Bubendorf, Yuemin Tian, Uwe Güth, Barbara Wijker, Guido Sauter, Christian Ruiz, Martin Oeggerli, Ellen C. Obermann

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e41664 (2012)
PloS one
Oeggerli, Martin; Tian, Yuemin; Ruiz, Christian; Wijker, Barbara; Sauter, Guido; Obermann, Ellen; Güth, Uwe; Zlobec, Inti; Sausbier, Matthias; Kunzelmann, Karl; Bubendorf, Lukas (2012). Role of KCNMA1 in breast cancer. PLoS ONE, 7(8), e41664. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0041664
PLoS ONE

KCNMA1 encodes the α-subunit of the large conductance, voltage and Ca(2+)-activated (BK) potassium channel and has been reported as a target gene of genomic amplification at 10q22 in prostate cancer. To investigate the prevalence of the amplificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0647d1e08686ccbab0dd0094399a23
http://europepmc.org/articles/PMC3416802?pdf=render

E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer

Autor: Ronald Simon, Hedvika Novotny, Michael Bloch, Peter Schraml, Guido Sauter, Martin Oeggerli, Martina Mirlacher, Christian Ruiz

Publikováno v: Oncogene. 25(49)

Amplification of 6p22 occurs in about 10-20% of bladder cancers and is associated with enhanced tumour cell proliferation. Candidate target genes for the 6p22 amplicon include E2F3 and the adjacent gene NM_017774. To clarify which gene is representin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7478526ae64386ef58164186abcdd03b
https://pubmed.ncbi.nlm.nih.gov/16953223