Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Martin, Loignon"'
Publikováno v:
Vaccines, Vol 12, Iss 5, p 524 (2024)
Adenoviruses are efficient and safe vectors for delivering target antigens and adenovirus-based vaccines have been used against a wide variety of pathogens, including tuberculosis and COVID-19. Cost-effective and scalable biomanufacturing processes a
Externí odkaz:
https://doaj.org/article/73dc1a4654dc433ab6363bfeb86b5dfc
Autor:
Chun Fang, Shen, Sonia, Tremblay, Catherine, Sabourin-Poirier, Elodie, Burney, Sophie, Broussau, Aziza, Manceur, Anja, Rodenbrock, Robert, Voyer, Martin, Loignon, Sven, Ansorge, Rénald, Gilbert
Publikováno v:
Bioprocess and Biosystems Engineering. 45:1267-1280
The growing interest in the use of lentiviral vectors (LVs) for various applications has created a strong demand for large quantities of vectors. To meet the increased demand, we developed a high cell density culture process for production of LV usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a15eeff6d25f501b0ccebb0724e4bc
https://doi.org/10.1007/s00449-022-02737-5
https://doi.org/10.1007/s00449-022-02737-5
Autor:
Jean‐Sébastien Maltais, Simon Lord‐Dufour, Audrey Morasse, Matthew Stuible, Martin Loignon, Yves Durocher
Publikováno v:
Biotechnology and Bioengineering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::913e375913acc99d0e35f980793227a4
https://doi.org/10.1002/bit.28435
https://doi.org/10.1002/bit.28435
Chinese hamster ovary (CHO) cell-based platforms are the most widely used for the biomanufacturing of complex therapeutic proteins, such as monoclonal antibodies (mAbs). The development of high-producing clones that are stable and amenable to large-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1489eda0e927f178881e95e274f34d15
https://doi.org/10.1080/07388551.2020.1768043
https://doi.org/10.1080/07388551.2020.1768043
Autor:
Daniel Larocque, Gabriela Fragoso, Jinghan Huang, Walter E Mushynski, Martin Loignon, Stéphane Richard, Guillermina Almazan
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5867 (2009)
BACKGROUND:The quaking viable (qk(v)) mice have uncompacted myelin in their central and peripheral nervous system (CNS, PNS). The qk gene encodes 3 major alternatively spliced isoforms that contain unique sequence at their C-terminus dictating their
Externí odkaz:
https://doaj.org/article/689ebfdfc6a3481592630c7b8556ebea
Autor:
Eric Grazzini, Jason Baardsnes, Alina Burlacu, Sylvie Perret, Yves Durocher, Martin Loignon, Matthew Stuible, Denis Brochu, Beatrice Paul-Roc
Publikováno v:
Journal of biotechnology. 281
For pre-clinical evaluation of biotherapeutic candidates, protein production by transient gene expression (TGE) in Chinese Hamster Ovary (CHO) cells offers important advantages, including the capability of rapidly and cost-effectively generating reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42b7261e196f3a44b8d2289f098740
https://pubmed.ncbi.nlm.nih.gov/29886030
https://pubmed.ncbi.nlm.nih.gov/29886030
Publikováno v:
Cancer Chemotherapy and Pharmacology. 66:467-474
Nrf2 is a key transcription factor, which induces a cytoprotective gene array. Nrf2 is regulated at the posttranslational level through proteasomal degradation through an interaction with the adapter protein Keap1. High levels of Nrf2, resulting from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8857cd478e295fedcdaa200395808aa7
https://doi.org/10.1007/s00280-009-1182-7
https://doi.org/10.1007/s00280-009-1182-7
Publikováno v:
Journal of Biological Chemistry. 283:5533-5541
In response to diverse genotoxic stimuli (e.g. UV and cisplatin), the mitogen-activated protein kinases ERK1/2, JNK1/2, and p38alpha/beta become rapidly phosphorylated and in turn activate multiple downstream effectors that modulate apoptosis and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687e873625abf4e2f93330a5fd561765
https://doi.org/10.1074/jbc.m706257200
https://doi.org/10.1074/jbc.m706257200
Autor:
Moulay A. Alaoui-Jamali, Naciba Benlimame, Dingzhang Xiao, Su Jie, David D. Schlaepfer, Yingjie Xu, Martin Loignon, Qiang He
Publikováno v:
The Journal of Cell Biology
The overexpression of members of the ErbB tyrosine kinase receptor family has been associated with cancer progression. We demonstrate that focal adhesion kinase (FAK) is essential for oncogenic transformation and cell invasion that is induced by ErbB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67ead698b97f9c11d9a302be21b9a42
http://europepmc.org/articles/PMC2171271
http://europepmc.org/articles/PMC2171271
Autor:
John Hiscott, Raymond Césaire, Moulay A. Alaoui-Jamali, Yael Mamane, Eduardo Hernandez, Jennifer Palmer, Martin Loignon
Publikováno v:
Journal of Interferon & Cytokine Research. 25:43-51
Human T cell leukemia virus (HTLV) is the causative agent of adult T cell leukemia (ATL), an aggressive and fatal leukemia of CD4+ T lymphocytes in which interferon regulatory factor-4 (IRF-4) becomes constitutively expressed, concomitant with major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75121c6e3a274281bb3a115e24471d2
https://doi.org/10.1089/jir.2005.25.43
https://doi.org/10.1089/jir.2005.25.43