Hypersensitive quantification of major astringency markers in food and wine by substoichiometric quenching of silicon-rhodamine conjugates

Autor: Daniel Bátora, Ágnes Dienes-Nagy, Liming Zeng, Christian E. Gerber, Jérôme P. Fischer, Martin Lochner, Jürg Gertsch

Publikováno v: Food Chemistry: X, Vol 23, Iss , Pp 101592- (2024)

Tannins are chemically diverse polyphenols in plant-derived products that not only show diverse biological activities but also play a crucial role in determining the sensory attributes of food and beverages. Therefore, their accurate and cost-effecti

Externí odkaz: https://doaj.org/article/d5fcab5656db494b9c7ac8e066ac4186

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

Autor: Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-re

Externí odkaz: https://doaj.org/article/248fd0638f5942beb0219612bf9fe670

Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors

Autor: Prakash Arullampalam, Barbara Preti, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sébastien Rougier, Hugues Abriel

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Background: The Transient Receptor Potential Melastatin member 4 (TRPM4) gene encodes a calcium-activated non-selective cation channel expressed in several tissues. Mutations in TRPM4 have been reported in patients with different types of cardiac con

Externí odkaz: https://doaj.org/article/21cf137dbdef48c6a253499e00e162a1

Species-dependent actions of the Goαb selective adenosine A1receptor agonist BnOCPA

Autor: Emily Hill, Xianglin Huang, Ivana Del Popolo, Circe La Mache, Martin Lochner, Graham Ladds, Bruno G. Frenguelli, Mark J. Wall

SummaryWe have previously reported that in rat hippocampal area CA1, the A1R-selective agonist, BnOCPA, potently inhibited excitatory synaptic transmission but did not cause membrane hyperpolarisation in CA1 pyramidal neurons, as would be expected of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3a0608d52e5c70e4b6300aaabc32aab
https://doi.org/10.1101/2022.12.02.518704

Functional design of bacterial superoxide:quinone oxidoreductase

Autor: Abbas Abou-Hamdan, Roman Mahler, Philipp Grossenbacher, Olivier Biner, Dan Sjöstrand, Martin Lochner, Martin Högbom, Christoph von Ballmoos

Publikováno v: Abou Hamdan, Abbas; Mahler, Roman; Grossenbacher, Philipp; Biner, Olivier; Sjöstrand, Dan; Lochner, Martin; Högbom, Martin; von Ballmoos, Christoph (2022). Functional design of bacterial superoxide:quinone oxidoreductase. Biochimica et biophysica acta. Bioenergetics, 1863(7), p. 148583. Elsevier 10.1016/j.bbabio.2022.148583

The superoxide anion - molecular oxygen reduced by a single electron - is produced in large amounts by enzymatic and adventitious reactions and can perform a range of cellular functions, including bacterial warfare and iron uptake, signalling and hos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45e63f8c88e8af7797b3f817673776c
https://boris.unibe.ch/170499/9/1-s2.0-S0005272822000524-main.pdf