Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Martin, Haslbeck"'
Autor:
Karin Taş, Beatrice Dalla Volta, Christina Lindner, Omar El Bounkari, Kathleen Hille, Yuan Tian, Xènia Puig-Bosch, Markus Ballmann, Simon Hornung, Martin Ortner, Sophia Prem, Laura Meier, Gerhard Rammes, Martin Haslbeck, Christian Weber, Remco T. A. Megens, Jürgen Bernhagen, Aphrodite Kapurniotu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Amyloid self-assembly is linked to type 2 diabetes and Alzheimer’s disease. Here the authors designed constrained peptides which are nanomolar amyloid inhibitors of the key polypeptides IAPP and Aβ42 and act via supramolecular nanofiber co-assembl
Externí odkaz:
https://doaj.org/article/3b23585f88cb4b29866249912e9885cc
Autor:
Moritz Mühlhofer, Carsten Peters, Thomas Kriehuber, Marina Kreuzeder, Pamina Kazman, Natalia Rodina, Bernd Reif, Martin Haslbeck, Sevil Weinkauf, Johannes Buchner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Small heat shock proteins (sHsps) form large spherical assemblies and their regulation is not well understood. Here, the authors provide insights into the mechanism of Hsp26 activation by characterising phospho-mimetic mutants of yeast Hsp26. They pr
Externí odkaz:
https://doaj.org/article/ba936da34061418da4605d6f906d2c8a
Autor:
Susanne Meier, Sina Bohnacker, Carolin J. Klose, Abraham Lopez, Christian A. Choe, Philipp W. N. Schmid, Nicolas Bloemeke, Florian Rührnößl, Martin Haslbeck, Julia Esser-von Bieren, Michael Sattler, Po-Ssu Huang, Matthias J. Feige
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
It is unclear how unassembled secretory pathway proteins are discriminated from misfolded ones. Here the authors combine biophysical and cellular experiments to study the folding of heterodimeric interleukin 23 and describe how ER chaperones recogniz
Externí odkaz:
https://doaj.org/article/7a8999f450d04116918a03d1d6abd258
Autor:
Sebastian P. Schwaminger, Paula Fraga-García, Silvia A. Blank-Shim, Tamara Straub, Martin Haslbeck, Francesco Muraca, Kenneth A. Dawson, Sonja Berensmeier
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 3790-3799 (2019)
Externí odkaz:
https://doaj.org/article/85b85e81bcb04c3698abeb6035d8fd0b
Autor:
Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)
Cytochrome P450 2E1 (CYP2E1) is a key target protein in the development of alcoholic and nonalcoholic fatty liver disease (FLD). The pathophysiological correlate is the massive production of reactive oxygen species. The role of CYP2E1 in the developm
Externí odkaz:
https://doaj.org/article/e74a70f467514028b4d33139a1dbe072
Autor:
Moritz Mühlhofer, Evi Berchtold, Chris G. Stratil, Gergely Csaba, Elena Kunold, Nina C. Bach, Stephan A. Sieber, Martin Haslbeck, Ralf Zimmer, Johannes Buchner
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4593-4607.e8 (2019)
Summary: Life is resilient because living systems are able to respond to elevated temperatures with an ancient gene expression program called the heat shock response (HSR). In yeast, the transcription of hundreds of genes is upregulated at stress tem
Externí odkaz:
https://doaj.org/article/4d1484a5a9214374857af164b3a56f32
Autor:
Annika Strauch, Benjamin Rossa, Fabian Köhler, Simon Haeussler, Moritz Mühlhofer, Florian Rührnößl, Caroline Körösy, Yevheniia Bushman, Barbara Conradt, Martin Haslbeck, Sevil Weinkauf, Johannes Buchner
Publikováno v:
The Journal of biological chemistry. 299(1)
Small Heat shock proteins (sHsps) are a family of molecular chaperones that bind nonnative proteins in an ATP-independent manner. Caenorhabditis elegans encodes 16 different sHsps, among them Hsp17, which is evolutionarily distinct from other sHsps i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4087664ea822530cbe075cbbc5f1b5b5
https://pubmed.ncbi.nlm.nih.gov/36442512
https://pubmed.ncbi.nlm.nih.gov/36442512
Autor:
Ulrich Fabien, Prodjinotho, Vitka, Gres, Fiona, Henkel, Matthew, Lacorcia, Ramona, Dandl, Martin, Haslbeck, Veronika, Schmidt, Andrea Sylvia, Winkler, Chummy, Sikasunge, Per-Johan, Jakobsson, Philipp, Henneke, Julia, Esser-von Bieren, Clarissa, Prazeres da Costa
Publikováno v:
EMBO reports. 23(5)
Immunoregulation of inflammatory, infection-triggered processes in the brain constitutes a central mechanism to control devastating disease manifestations such as epilepsy. Observational studies implicate the viability of Taenia solium cysts as key f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6eb0fbde13b7d8f895ff88d9b5c27532
https://pubmed.ncbi.nlm.nih.gov/35357743
https://pubmed.ncbi.nlm.nih.gov/35357743
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140487 (2015)
mRNA splicing is required in about 4% of protein coding genes in Saccharomyces cerevisiae. The gene structure of those genes is simple, generally comprising two exons and one intron. In order to characterize the impact of alternative splicing on the
Externí odkaz:
https://doaj.org/article/b7e5411e0e314f768a4bbb6eca6f2767
Autor:
Alexander M. Herrmann, Paul M. D'Agostino, Zhengyi Qian, Hans-Peter Fiedler, Noémi Antal, Tobias A. M. Gulder, Ruth Brack-Werner, Torsten Bruhn, Martin Haslbeck
Publikováno v:
The Journal of Organic Chemistry. 85:664-673
Genome sequencing and bioinformatic analysis have identified numerous cryptic gene clusters that have the potential to produce novel natural products. Within this work, we identified a cryptic type II PKS gene cluster (skt) from Streptomyces sp. Tu 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7333bd1641d02789415a2b4dbc1c13a6
https://doi.org/10.1021/acs.joc.9b02741
https://doi.org/10.1021/acs.joc.9b02741