Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Martin, Haraldsson"'
Autor:
Si Min Zhang, Cynthia B.J. Paulin, Huazhang Shu, Miriam Yagüe-Capilla, Maurice Michel, Petra Marttila, Florian Ortis, Henri Colyn Bwanika, Christopher Dirks, Rajagopal Papagudi Venkatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Femke M. Hormann, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Hanna Axelsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108907- (2024)
Summary: SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as neoa
Externí odkaz:
https://doaj.org/article/62a8b016c8c04843b50875f18c4706f6
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/0c0c030dc1c54c61a794787a99cca008
Autor:
Tatiana A. Giovannucci, Florian A. Salomons, Martin Haraldsson, Lotta H. M. Elfman, Malin Wickström, Patrick Young, Thomas Lundbäck, Jürgen Eirich, Mikael Altun, Rozbeh Jafari, Anna-Lena Gustavsson, John Inge Johnsen, Nico P. Dantuma
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-19 (2021)
Abstract Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery
Externí odkaz:
https://doaj.org/article/40038c990d214b6aae378be5f01e4f1b
Autor:
Paola Pellegrini, Jason T. Serviss, Thomas Lundbäck, Nicolo Bancaro, Magdalena Mazurkiewicz, Iryna Kolosenko, Di Yu, Martin Haraldsson, Padraig D’Arcy, Stig Linder, Angelo De Milito
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-15 (2018)
Abstract Background Drug screening for the identification of compounds with anticancer activity is commonly performed using cell lines cultured under normal oxygen pressure and physiological pH. However, solid tumors are characterized by a microenvir
Externí odkaz:
https://doaj.org/article/256bdaa793dd4bd58c5a42f76fff9c1e
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract The development of non-genotoxic therapies that activate wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor suppressor. Here we report the identification of over 100 small-molecules activating p53 in cells. We
Externí odkaz:
https://doaj.org/article/c70bab1df6ec4076bb2c93aa455abeeb
Autor:
Helena Almqvist, Hanna Axelsson, Rozbeh Jafari, Chen Dan, André Mateus, Martin Haraldsson, Andreas Larsson, Daniel Martinez Molina, Per Artursson, Thomas Lundbäck, Pär Nordlund
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Drugs therapeutic efficacy relies on their capability of binding the relevant targets in a physiological environment, which has so far been hard to measure. Here, the authors present a compound library screen based on a target engagement assay that r
Externí odkaz:
https://doaj.org/article/07cf88c839fd460490c598e8b7898ec9
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc803a4ce48681e11987b33fd0a94af
https://doi.org/10.1038/s43018-022-00331-y
https://doi.org/10.1038/s43018-022-00331-y
Autor:
Michael Andäng, Per Øyvind Enger, Sven Nelander, C. Theresa Vincent, Lukas Trantirek, Per Uhlén, Sten Linnarsson, A.F. Maarten Altelaar, Lene Uhrbom, Annika Jenmalm Jensen, Lars G.J. Hammarström, Anna-Lena Gustavsson, Martin Haraldsson, Anna Segerman, Voichita D. Marinescu, Jennifer M. Feenstra, Brittany B. Carson, Michaela Krafcikova, Gregorios Kyriatzis, Ivar Dehnisch, Nicolas Fritz, Linnéa Schmidt, Petra Sekyrova, Shimei Wee, Ercan Mutlu, Zuzana Sramkova, Gianluca Maddalo, Mia Niklasson
Proteomics and phosphoproteomics data analyses II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf457451988cb727ae8d43bb6259c300
https://doi.org/10.1158/0008-5472.22417671
https://doi.org/10.1158/0008-5472.22417671
Autor:
Michael Andäng, Per Øyvind Enger, Sven Nelander, C. Theresa Vincent, Lukas Trantirek, Per Uhlén, Sten Linnarsson, A.F. Maarten Altelaar, Lene Uhrbom, Annika Jenmalm Jensen, Lars G.J. Hammarström, Anna-Lena Gustavsson, Martin Haraldsson, Anna Segerman, Voichita D. Marinescu, Jennifer M. Feenstra, Brittany B. Carson, Michaela Krafcikova, Gregorios Kyriatzis, Ivar Dehnisch, Nicolas Fritz, Linnéa Schmidt, Petra Sekyrova, Shimei Wee, Ercan Mutlu, Zuzana Sramkova, Gianluca Maddalo, Mia Niklasson
Cell death analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18702f250a0815a1b1987224fa61b3f3
https://doi.org/10.1158/0008-5472.22417689.v1
https://doi.org/10.1158/0008-5472.22417689.v1
Autor:
Michael Andäng, Per Øyvind Enger, Sven Nelander, C. Theresa Vincent, Lukas Trantirek, Per Uhlén, Sten Linnarsson, A.F. Maarten Altelaar, Lene Uhrbom, Annika Jenmalm Jensen, Lars G.J. Hammarström, Anna-Lena Gustavsson, Martin Haraldsson, Anna Segerman, Voichita D. Marinescu, Jennifer M. Feenstra, Brittany B. Carson, Michaela Krafcikova, Gregorios Kyriatzis, Ivar Dehnisch, Nicolas Fritz, Linnéa Schmidt, Petra Sekyrova, Shimei Wee, Ercan Mutlu, Zuzana Sramkova, Gianluca Maddalo, Mia Niklasson
Supplementary Figure Legends and Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d8d8a6c4b80f24190b26c2d942d1d9
https://doi.org/10.1158/0008-5472.22417686
https://doi.org/10.1158/0008-5472.22417686