Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Martin, Gramatzki"'
Autor:
Sebastian Lutz, Katja Klausz, Anca-Maria Albici, Lea Ebinger, Lea Sellmer, Hannah Teipel, André Frenzel, Anna Langner, Dorothee Winterberg, Steffen Krohn, Michael Hust, Thomas Schirrmann, Stefan Dübel, Regina Scherließ, Andreas Humpe, Martin Gramatzki, Christian Kellner, Matthias Peipp
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The activating receptor natural killer group 2, member D (NKG2D) represents an attractive target for immunotherapy as it exerts a crucial role in cancer immunosurveillance by regulating the activity of cytotoxic lymphocytes. In this study, a panel of
Externí odkaz:
https://doaj.org/article/7c5953b3bdb248e2bc422fe95902d787
Autor:
Steffen Krohn, Ammelie Svea Boje, Carina Lynn Gehlert, Sebastian Lutz, Nikos Darzentas, Henrik Knecht, Dietrich Herrmann, Monika Brüggemann, Axel J. Scheidig, Katja Weisel, Martin Gramatzki, Matthias Peipp, Katja Klausz
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
To identify new antibodies for the treatment of plasma cell disorders including multiple myeloma (MM), a single-chain Fragment variable (scFv) antibody library was generated by immunizing mice with patient-derived malignant plasma cells. To enrich an
Externí odkaz:
https://doaj.org/article/67012a1ee1a04392926447c7d0107282
Publikováno v:
Haematologica, Vol 106, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/9cf48112f4f649bcbef298962860da04
Autor:
Katja Klausz, Michael Cieker, Christian Kellner, Thies Rösner, Anna Otte, Steffen Krohn, Anja Lux, Falk Nimmerjahn, Thomas Valerius, Martin Gramatzki, Matthias Peipp
Publikováno v:
Haematologica, Vol 106, Iss 7 (2020)
Despite several therapeutic advances, patients with multiple myeloma (MM) require additional treatment options since no curative therapy exists yet. In search of a novel therapeutic antibody, we previously applied phage display with myeloma cell scre
Externí odkaz:
https://doaj.org/article/edc2b2aa1c2c4a639e7ce8d4a6cb30c7
Autor:
Stefanie Binder, Nadine Hösler, Diana Riedel, Ivonne Zipfel, Tilo Buschmann, Christoph Kämpf, Kristin Reiche, Renate Burger, Martin Gramatzki, Jörg Hackermüller, Peter F. Stadler, Friedemann Horn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Interleukin-6 (IL-6)-activated Signal Transducer and Activator of Transcription 3 (STAT3) facilitates survival in the multiple myeloma cell line INA-6 and therefore represents an oncogenic key player. However, the biological mechanisms are s
Externí odkaz:
https://doaj.org/article/b2635f07e4274b1dbd4f152516ba887d
Autor:
Eolia Brissot, Myriam Labopin, Matthias Stelljes, Gerhard Ehninger, Rainer Schwerdtfeger, Jürgen Finke, Hans-Jochem Kolb, Arnold Ganser, Kerstin Schäfer-Eckart, Axel R. Zander, Donald Bunjes, Stephan Mielke, Wolfgang A. Bethge, Noël Milpied, Peter Kalhs, Igor-Woflgang Blau, Nicolaus Kröger, Antonin Vitek, Martin Gramatzki, Ernst Holler, Christoph Schmid, Jordi Esteve, Mohamad Mohty, Arnon Nagler
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Background Primary refractory acute myeloid leukemia (PRF-AML) is associated with a dismal prognosis. Allogeneic stem cell transplantation (HSCT) in active disease is an alternative therapeutic strategy. The increased availability of unrelat
Externí odkaz:
https://doaj.org/article/9d0a51f6b1c14c8989702f863a85f779
Autor:
Matthias Peipp, Martin Gramatzki, Bernd Clement, Dirk O. Bauerschlag, Andreas Günther, Inken Floerkemeier, Hauke Wilcken, Steffen Krohn, Carina Lynn Gehlert, Christian Kellner, Katja Klausz
P8-D6 is a novel dual inhibitor of human topoisomerase I (TOP1) and II (TOP2) with broad pro-apoptotic antitumor activity. NCI-60 screening revealed markedly improved cytotoxicity of P8-D6 against solid and leukemia cell lines compared with other sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da6d0e8e73b4e09348a7b5d8e131497
https://doi.org/10.1158/1535-7163.c.6543349.v1
https://doi.org/10.1158/1535-7163.c.6543349.v1
Autor:
Matthias Peipp, Martin Gramatzki, Bernd Clement, Dirk O. Bauerschlag, Andreas Günther, Inken Floerkemeier, Hauke Wilcken, Steffen Krohn, Carina Lynn Gehlert, Christian Kellner, Katja Klausz
Supplementary Figures 1-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dbe22b0e070924be809f33addf7faa
https://doi.org/10.1158/1535-7163.22522354
https://doi.org/10.1158/1535-7163.22522354
Autor:
Daniela Wesch, Dieter Kabelitz, Martin Gramatzki, Sandra Freitag-Wolf, Dietrich Weisner, Ilka Vogel, Thomas Becker, Christoph Röcken, Sabine Adam-Klages, Domantas Petrick, Sarah Krause, Susanne Sebens, Christian Kellner, Matthias Peipp, Hans-Heinrich Oberg
PDF file - 38K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f69e28d66cbfad849a055d703086410d
https://doi.org/10.1158/0008-5472.22401371
https://doi.org/10.1158/0008-5472.22401371
Autor:
Daniela Wesch, Dieter Kabelitz, Martin Gramatzki, Sandra Freitag-Wolf, Dietrich Weisner, Ilka Vogel, Thomas Becker, Christoph Röcken, Sabine Adam-Klages, Domantas Petrick, Sarah Krause, Susanne Sebens, Christian Kellner, Matthias Peipp, Hans-Heinrich Oberg
The ability of human γδ T cells from healthy donors to kill pancreatic ductal adenocarcinoma (PDAC) in vitro and in vivo in immunocompromised mice requires the addition of γδ T-cell–stimulating antigens. In this study, we demonstrate that γδ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4640c31b092b29af6b6771e1511af9c2
https://doi.org/10.1158/0008-5472.c.6505850
https://doi.org/10.1158/0008-5472.c.6505850