Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Martin, Gleave"'
Autor:
Sara Harsini, Don Wilson, Heather Saprunoff, Hayley Allan, Martin Gleave, Larry Goldenberg, Kim N. Chi, Charmaine Kim-Sing, Scott Tyldesley, François Bénard
Publikováno v:
Cancer Imaging, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Radiotherapy (RT) and surgery are potential treatment options in patients with biochemical recurrence (BCR) following primary prostate cancer treatment. This study examines the value of prostate-specific membrane antigen (PSMA) po
Externí odkaz:
https://doaj.org/article/5f8751b6c9444577adc256ab103c63e4
Autor:
Thomas C. Westbrook, Xiangnan Guan, Eva Rodansky, Diana Flores, Chia Jen Liu, Aaron M. Udager, Radhika A. Patel, Michael C. Haffner, Ya-Mei Hu, Duanchen Sun, Tomasz M. Beer, Adam Foye, Rahul Aggarwal, David A. Quigley, Jack F. Youngren, Charles J. Ryan, Martin Gleave, Yuzhuo Wang, Jiaoti Huang, Ilsa Coleman, Colm Morrissey, Peter S. Nelson, Christopher P. Evans, Primo Lara, Robert E. Reiter, Owen Witte, Matthew Rettig, Christopher K. Wong, Alana S. Weinstein, Vlado Uzunangelov, Josh M. Stuart, George V. Thomas, Felix Y. Feng, Eric J. Small, Joel A. Yates, Zheng Xia, Joshi J. Alumkal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Lineage plasticity is increasingly recognized as an emergent resistance mechanism after treatment with androgen receptor signalling inhibitors. To understand determinants of resistance, the authors analyzed the transcriptomes of patient tumor biopsie
Externí odkaz:
https://doaj.org/article/84a852fcb0624999ab330bdca23f4d3f
Autor:
Neha Singh, Varune R. Ramnarine, Jin H. Song, Ritu Pandey, Sathish K. R. Padi, Mannan Nouri, Virginie Olive, Maxim Kobelev, Koichi Okumura, David McCarthy, Michelle M. Hanna, Piali Mukherjee, Belinda Sun, Benjamin R. Lee, J. Brandon Parker, Debabrata Chakravarti, Noel A. Warfel, Muhan Zhou, Jeremiah J. Bearss, Ewan A. Gibb, Mohammed Alshalalfa, R. Jefferey Karnes, Eric J. Small, Rahul Aggarwal, Felix Feng, Yuzhuo Wang, Ralph Buttyan, Amina Zoubeidi, Mark Rubin, Martin Gleave, Frank J. Slack, Elai Davicioni, Himisha Beltran, Colin Collins, Andrew S. Kraft
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Elevated expression of long noncoding RNA H19 is seen in clinical samples of neuroendocrine prostate cancer (PCa). Here the authors show H19 promotes plasticity from luminal to neuroendocrine by epigenetic reprogramming.
Externí odkaz:
https://doaj.org/article/fe3ffb322dcb47a8b750da286a3e5ab2
Autor:
Meixia Che, Aashi Chaturvedi, Sarah A. Munro, Samuel P. Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M. Bergman, Tesa M. Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A. Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason S. Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C. Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R. Stephanie Huang, Scott M. Dehm
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the
Externí odkaz:
https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a91
Autor:
Satyam Bhasin, Christopher Dusek, James W. Peacock, Artem Cherkasov, Yuzhuo Wang, Martin Gleave, Christopher J. Ong
Publikováno v:
Cells, Vol 12, Iss 13, p 1715 (2023)
Estrogen receptor positive (ER+) breast cancer (BCa) accounts for the highest proportion of breast cancer-related deaths. While endocrine therapy is highly effective for this subpopulation, endocrine resistance remains a major challenge and the ident
Externí odkaz:
https://doaj.org/article/ce525f990ef941c8b21cdd5b891206db
Publikováno v:
Société Internationale d’Urologie Journal, Vol 2, Iss Suppl. 1, Pp 1-22 (2021)
None.
Externí odkaz:
https://doaj.org/article/c8fc3b0e37cb442e863c486dfffbc846
Autor:
Neetu Saxena, Eliana Beraldi, Ladan Fazli, Syam Prakash Somasekharan, Hans Adomat, Fan Zhang, Chidi Molokwu, Anna Gleave, Lucia Nappi, Kimberly Nguyen, Pavn Brar, Nicholas Nikesitch, Yuzhuo Wang, Colin Collins, Poul H Sorensen, Martin Gleave
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp 1-19 (2021)
Abstract Treatment‐induced adaptive pathways converge to support androgen receptor (AR) reactivation and emergence of castration‐resistant prostate cancer (PCa) after AR pathway inhibition (ARPI). We set out to explore poorly defined acute adapti
Externí odkaz:
https://doaj.org/article/5793efb5d6f840efadd0ab2793d10dfc
Autor:
Thomas Kryza, Nathalie Bock, Scott Lovell, Anja Rockstroh, Melanie L. Lehman, Adam Lesner, Janaththani Panchadsaram, Lakmali Munasinghage Silva, Srilakshmi Srinivasan, Cameron E. Snell, Elizabeth D. Williams, Ladan Fazli, Martin Gleave, Jyotsna Batra, Colleen Nelson, Edward W. Tate, Jonathan Harris, John D. Hooper, Judith A. Clements
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 105-128 (2020)
Kallikrein‐related peptidase 14 (KLK14) is one of the several secreted KLK serine proteases involved in prostate cancer (PCa) pathogenesis. While relatively understudied, recent reports have identified KLK14 as overexpressed during PCa development.
Externí odkaz:
https://doaj.org/article/d544b520f038431180fefe9421c7d971
Autor:
Jindan Luo, Yinan Li, Wei Zheng, Ning Xie, Yao Shi, Zhi Long, Liping Xie, Ladan Fazli, Dahong Zhang, Martin Gleave, Xuesen Dong
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 916-926 (2019)
The linear mRNAs transcribed under alternative RNA splicing and overexpression/amplification of the androgen receptor (AR) gene are poor prognostic biomarkers of castrate-resistant prostate cancer (PCa). Whether the AR gene also transcribes non-codin
Externí odkaz:
https://doaj.org/article/c70030e9b27640dba363a2cb0a07710b
Autor:
Martin Gleave, Brad Rosbrook, Stephen J Freedland, Qi Shen, Jennifer Sugg, Gabriel P Haas, Neal D Shore
Publikováno v:
BMJ Open, Vol 11, Iss 8 (2021)
Introduction Limited data from controlled clinical trials are available for men who experience biochemical recurrence after definitive therapy for prostate cancer. In the absence of overt metastases, patients with non-metastatic castration-sensitive
Externí odkaz:
https://doaj.org/article/f307eba0fed64f1387210572e1de35fb