Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Martin, Gilar"'
Autor:
Pratheeba Yogendrarajah, Irene Suarez Marina, Willy Verluyten, Evelien Dejaegere, Leslie Napoletano, Jean-Paul Boon, Mario Hellings, Martin Gilar
Publikováno v:
LCGC North America. :60-66
In this paper, we describe denaturing and non-denaturing ion-pair reversed-phase liquid chromatography (RPLC) methods for analyzing small interfering ribonucleic acid (siRNA). Drug formulations consisting of one or two siRNA duplexes were analyzed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e4709e1d57c8f18182da75a651b8b20
https://doi.org/10.56530/lcgc.na.zs3766l5
https://doi.org/10.56530/lcgc.na.zs3766l5
Publikováno v:
Journal of Separation Science. 45:3264-3275
We compared the separation selectivities of 19 different hydrophilic interaction chromatography columns. The stationary phases included underivatized silica and hybrid particles, cyano-bonded silica, materials with neutral ligands such as amide, diol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967a3530d53397f0c8b9df34d13cd1fb
https://doi.org/10.1002/jssc.202200165
https://doi.org/10.1002/jssc.202200165
Autor:
Roopali Roy, Elisa Schunkert, Petra Olivova, Martin Gilar, Scott Geromanos, Guo-Zhong Li, John Gebler, Adelle Dagher, Andrew El-Hayek, Rama Aldakhlallah, David Zurakowski, Susan Pories, Marsha A. Moses
Publikováno v:
Cancer Research. 83:3433-3433
Introduction: Breast cancer (BC) is a complex heterogenous disease and is a leading cause of death in women. Following primary BC therapy ~40% of patients will develop metastatic BC (MBC) and 60-70% of the recurrent disease will occur at distant site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08976d49e333c1fc68e727877cd97820
https://doi.org/10.1158/1538-7445.am2023-3433
https://doi.org/10.1158/1538-7445.am2023-3433
Autor:
Michael Donegan, Jennifer M. Nguyen, Jason MacLean, Brooke M. Koshel, Martin Gilar, Zhimin Li, Matthew A. Lauber
Publikováno v:
Nguyen, J M, Gilar, M, Koshel, B, Donegan, M, Maclean, J, Li, Z & Lauber, M A 2021, ' Assessing the impact of nonspecific binding on oligonucleotide bioanalysis ', Bioanalysis, vol. 13, no. 16, pp. 1233-1244 . https://doi.org/10.4155/bio-2021-0115
Aim: Accurate and reliable quantification of oligonucleotides can be difficult, which has led to an increased focus on bioanalytical methods for more robust analyses. Recent advances toward mitigating sample losses on liquid chromatography (LC) syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11cac6cccc1f8f45abeb2cb7323df3a
https://pubmed.ncbi.nlm.nih.gov/34472373
https://pubmed.ncbi.nlm.nih.gov/34472373
Autor:
Martin Gilar, Fabrice Gritti
Publikováno v:
Journal of Chromatography A. 1591:110-119
The impact of porous frits (2.1 mm i.d. × 1 mm thick, 0.2 μm porosity, 20% void, 0.69 μL) in short 0.5–5 cm long × 2.1 mm i.d. columns packed with sub-2 μm superficially porous particles on gradient performance was investigated using a low dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c745d056b7a55fa25a9211d59dd5d8
https://doi.org/10.1016/j.chroma.2019.01.021
https://doi.org/10.1016/j.chroma.2019.01.021
Autor:
Martin Gilar, Zuzana Kadlecová, Oleksandr Kozlov, Eva Tesařová, Květa Kalíková, Taťána Gondová
Publikováno v:
SEPARATION SCIENCE PLUS. 2:81-88
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da6ad94b631598125b534d035c56d5a2
https://doi.org/10.1002/sscp.201900023
https://doi.org/10.1002/sscp.201900023
Publikováno v:
Journal of Chromatography A. 1681:463473
Analysis of diastereomers of phosphorothioate oligonucleotides in ion-pairing reversed-phase liquid chromatography is affected not only by the character and concentration of ion-pairing system, but also by the separation temperature. In this work, ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a848aac850c2ca8a2826175e932cb0d
https://doi.org/10.1016/j.chroma.2022.463473
https://doi.org/10.1016/j.chroma.2022.463473
Publikováno v:
Journal of Chromatography A. 1676:463201
Ion-pairing reversed-phase liquid chromatography was utilized for the analysis of native and phosphorothioate oligonucleotides of the identical sequence but different amount and position of phosphorothioate modifications. The effects of ion-pairing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154a5211db1df89d28c788162c524a54
https://doi.org/10.1016/j.chroma.2022.463201
https://doi.org/10.1016/j.chroma.2022.463201
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 208
Nonspecific adsorption has been a consistent challenge in the analysis of oligonucleotides. Nonspecific adsorption is a result of interactions between charged acidic analytes and adsorption sites present in metallic surfaces located in the fluidic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba13a60d287ecf88472cf5d6c5c0c87
https://pubmed.ncbi.nlm.nih.gov/34742118
https://pubmed.ncbi.nlm.nih.gov/34742118
Autor:
Thomas H. Walter, Delano Mathew H, Andrew Bates-Harrison, Moon Chul Jung, Kevin D. Wyndham, Jennifer M. Nguyen, Matthew A. Lauber, Amit V. Patel, Cheryl A. Boissel, Martin Gilar
Publikováno v:
Analytical chemistry. 93(14)
Interactions of analytes with metal surfaces in high-performance liquid chromatography (HPLC) instruments and columns have been reported to cause deleterious effects ranging from peak tailing to a complete loss of the analyte signal. These effects ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976c62bbce3bdae529f02c50ddcd96f4
https://pubmed.ncbi.nlm.nih.gov/33798331
https://pubmed.ncbi.nlm.nih.gov/33798331