Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

Autor: Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O'Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel, Tony Kelly

Publikováno v: eLife, Vol 13 (2024)

Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression to specific brain regions, can

Externí odkaz: https://doaj.org/article/b8900cde3cd141bbb3eac8eba698eaf9

Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation

Autor: Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C. Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E. Ehrnhoefer

Publikováno v: Neurobiology of Disease, Vol 182, Iss , Pp 106126- (2023)

Intraneuronal aggregates of the microtubule binding protein Tau are a hallmark of different neurodegenerative diseases including Alzheimer's disease (AD). In these aggregates, Tau is modified by posttranslational modifications such as phosphorylation

Externí odkaz: https://doaj.org/article/ff39934c4d48495f9ed3afb8322255d0

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Autor: Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei‐Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrmann, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, Andre Fischer

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2017)

Abstract Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcrip

Externí odkaz: https://doaj.org/article/c508142ad7ed44dda436f67105c1fa85

Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

Autor: Thomas Pfeiffer, Stefanie Poll, Stephane Bancelin, Julie Angibaud, VVG Krishna Inavalli, Kevin Keppler, Manuel Mittag, Martin Fuhrmann, U Valentin Nägerl

Publikováno v: eLife, Vol 7 (2018)

Rewiring neural circuits by the formation and elimination of synapses is thought to be a key cellular mechanism of learning and memory in the mammalian brain. Dendritic spines are the postsynaptic structural component of excitatory synapses, and thei

Externí odkaz: https://doaj.org/article/63c2386c7d1245d9af3b2f5e1f6a4d22

Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability

Autor: Fabio Bertan, Lena Wischhof, Liudmila Sosulina, Manuel Mittag, Dennis Dalügge, Alessandra Fornarelli, Fabrizio Gardoni, Elena Marcello, Monica Di Luca, Martin Fuhrmann, Stefan Remy, Daniele Bano, Pierluigi Nicotera

Publikováno v: Cell Death & Differentiation
Cell death and differentiation, 27(12):3354-3373
Cell Death and Differentiation
Cell death and differentiation 27(12), 3354-3373 (2020). doi:10.1038/s41418-020-0584-2

Dendritic spines are postsynaptic domains that shape structural and functional properties of neurons. Upon neuronal activity, Ca2+ transients trigger signaling cascades that determine the plastic remodeling of dendritic spines, which modulate learnin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0277fd5150bdb3eaabea65eab22dcf
https://doi.org/10.1038/s41418-020-0584-2