Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Martin, Friedlander"'
Autor:
Kyle V. Marra, MD, PhD, Jimmy S. Chen, MD, Hailey K. Robles-Holmes, BS, Joseph Miller, MS, Guoqin Wei, PhD, Edith Aguilar, MD, Yoichiro Ideguchi, BS, Kristine B. Ly, BS, Sofia Prenner, Deniz Erdogmus, PhD, Napoleone Ferrara, MD, J. Peter Campbell, MD, MPH, Martin Friedlander, MD, PhD, Eric Nudleman, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 3, Pp 100439- (2024)
Purpose: The murine oxygen-induced retinopathy (OIR) model is one of the most widely used animal models of ischemic retinopathy, mimicking hallmark pathophysiology of initial vaso-obliteration (VO) resulting in ischemia that drives neovascularization
Externí odkaz:
https://doaj.org/article/2f181229b6884b8b8e69740bf8c277d3
Autor:
Jimmy S. Chen, MD, Kyle V. Marra, MD, PhD, Hailey K. Robles-Holmes, BS, Kristine B. Ly, BS, Joseph Miller, MS, Guoqin Wei, PhD, Edith Aguilar, MD, Felicitas Bucher, MD, PhD, Yoichi Ideguchi, BS, Aaron S. Coyner, PhD, Napoleone Ferrara, MD, J. Peter Campbell, MD, MPH, Martin Friedlander, MD, PhD, Eric Nudleman, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 1, Pp 100338- (2024)
Objective: To develop a generative adversarial network (GAN) to segment major blood vessels from retinal flat-mount images from oxygen-induced retinopathy (OIR) and demonstrate the utility of these GAN-generated vessel segmentations in quantifying va
Externí odkaz:
https://doaj.org/article/f3adeaa2abf74ce192a0b29e10d3cb0c
Autor:
Jessica D. Rosarda, Sarah Giles, Sarah Harkins-Perry, Elizabeth A. Mills, Martin Friedlander, R. Luke Wiseman, Kevin T. Eade
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However, the molecular mechanisms by which 1-dSLs induce toxicity in re
Externí odkaz:
https://doaj.org/article/66ae003ca45c4b5cb11a67b2487be644
Autor:
Simone Tzaridis, Martin Friedlander
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Externí odkaz:
https://doaj.org/article/59434242d0dd4edfa79d7282a694301a
Autor:
Courtney R. Green, Roberto Bonelli, Brendan R.E. Ansell, Simone Tzaridis, Michal K. Handzlik, Grace H. McGregor, Barbara Hart, Jennifer Trombley, Mary M. Reilly, Paul S. Bernstein, Catherine Egan, Marcus Fruttiger, Martina Wallace, Melanie Bahlo, Martin Friedlander, Christian M. Metallo, Marin L. Gantner
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101716- (2023)
Objectives: The non-essential amino acids serine, glycine, and alanine, as well as diverse sphingolipid species, are implicated in inherited neuro-retinal disorders and are metabolically linked by serine palmitoyltransferase (SPT), a key enzyme in me
Externí odkaz:
https://doaj.org/article/a1141ae99945415d9c14b187d2016bad
Autor:
Emily Y. Chew, MD, Tunde Peto, MD, PhD, Traci E. Clemons, PhD, Ferenc B. Sallo, MD, PhD, Daniel Pauleikhoff, MD, PhD, Irene Leung, BA, Glenn J. Jaffe, MD, Tjebo F.C. Heeren, MD, Catherine A. Egan, MD, Peter Charbel Issa, MD, PhD, Konstantinos Balaskas, MD, Frank G. Holz, MD, Alain Gaudric, MD, Alan C. Bird, MD, Martin Friedlander, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 2, Pp 100261- (2023)
Purpose: To develop a severity classification for macular telangiectasia type 2 (MacTel) disease using multimodal imaging. Design: An algorithm was used on data from a prospective natural history study of MacTel for classification development. Subjec
Externí odkaz:
https://doaj.org/article/8e52d23d291641379d3db5dc7d920159
Autor:
Kevin T. Eade, Brendan Robert E. Ansell, Sarah Giles, Regis Fallon, Sarah Harkins-Perry, Takayuki Nagasaki, Simone Tzaridis, Martina Wallace, Elizabeth A. Mills, Samaneh Farashi, Alec Johnson, Lydia Sauer, Barbara Hart, M. Elena Diaz-Rubio, Melanie Bahlo, Christian Metallo, Rando Allikmets, Marin L. Gantner, Paul S. Bernstein, Martin Friedlander
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Patient-derived induced pluripotent stem cells (iPSCs) provide a powerful tool for identifying cellular and molecular mechanisms of disease. Macular telangiectasia type 2 (MacTel) is a rare, late-onset degenerative retinal disease with an extremely h
Externí odkaz:
https://doaj.org/article/c36953378fea49618ef3b23be50c87cb
Autor:
Kyle V. Marra, Edith Aguilar, Guoqin Wei, Ayumi Usui-Ouchi, Yoichiro Ideguchi, Susumu Sakimoto, Martin Friedlander
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Disruption of the neurovascular unit (NVU) underlies the pathophysiology of various CNS diseases. One strategy to repair NVU dysfunction uses stem/progenitor cells to provide trophic support to the NVU’s functionally coupled and interdependent vasc
Externí odkaz:
https://doaj.org/article/81ff614729174767881acdd7c5fbdc19
Autor:
Roberto Bonelli, Victoria E. Jackson, Aravind Prasad, Jacob E. Munro, Samaneh Farashi, Tjebo F. C. Heeren, Nikolas Pontikos, Lea Scheppke, Martin Friedlander, MacTel Consortium, Catherine A. Egan, Rando Allikmets, Brendan R. E. Ansell, Melanie Bahlo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Melanie Bahlo and colleagues report a genome-wide association study on the retinal degenerative disease Macular Telangiectasia Type 2, identifying 8 new genome-wide significant loci. Further analyses suggest key roles for genes that transport and syn
Externí odkaz:
https://doaj.org/article/9cba7a84572b4acc832cac9a6d05482a
Autor:
Filipa Gomes Rodrigues, Menelaos Pipis, Tjebo F.C. Heeren, Marcus Fruttiger, Mari Gantner, Sandra Vermeirsch, Mali Okada, Martin Friedlander, Mary M Reilly, Catherine Egan
Publikováno v:
Journal of the Peripheral Nervous System. 27:215-224