Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)Research in context

Autor: Nicholas I. Paton, Wolfgang Stöhr, Alejandro Arenas-Pinto, Amanda Clarke, Ian Williams, Margaret Johnson, Chloe Orkin, Fabian Chen, Vincent Lee, Alan Winston, Mark Gompels, Julie Fox, Karen Sanders, David T. Dunn, Martin Fisher, Wendy Hadley, David Stacey, Pat Byrne, Nahum De Esteban, Pierre Pellegrino, Lewis Haddow, James Hand, Carl De Souza, Lisa Murthen, Andrew Crawford-Jones, Ruth Wilson, Elizabeth Green, John Masterson, Kamlesh Patel, Rebecca Howe, Scott Mullaney, Louise Jennings, Nicholas Beeching, Rebecca Tamaklo, Alistair Teague, Isabelle Jendrulek, Juan Manuel Tiraboschi, Ed Wilkins, Yvonne Clowes, Andrew Thompson, Gary Brook, Manoj Trivedi, Kazeem Aderogba, Martin Jones, Andrew DeBurgh-Thomas, Liz Jones, Iain Reeves, Sifiso Mguni, David Chadwick, Pauline Spence, Nellie Nkhoma, Zoe Warwick, Suzanne Price, Sally Read, Elbushra Herieka, James Walker, Ruth Woodward, John Day, Laura Hilton, Veerakathy Harinda, Helen Blackman, Phillip Hay, Wendy Mejewska, Olanike Okolo, Edmund Ong, Karen Martin, Lee Munro, David Dockrell, Lynne Smart, Jonathan Ainsworth, Anele Waters, Stephen Kegg, Sara McNamara, Steve Taylor, Gerry Gilleran, Brian Gazzard, Jane Rowlands, Sris Allan, Rumun Sandhu, Nigel O'Farrell, Sheena Quaid, Fabiola Martin, Caroline Bennett, Moses Kapembwa, Jane Minton, James Calderwood, Frank Post, Lucy Campbell, Emily Wandolo, Adrian Palfreeman, Linda Mashonganyika, Thambiah Balachandran, Memory Kakowa, Rebecca O'Connell, Cheryl Tanawa, Sinna Jebakumar, Lesley Hagger, Say Quah, Sinead McKernan, Charles Lacey, Sarah Douglas, Sarah Russell-Sharpe, Christine Brewer, Clifford Leen, Sheila Morris, Sharmin Obeyesekera, Shirley Williams, Nelson David, Mark Roberts, Julie Wollaston, Nicholas Paton, Karen Scott, David Dunn, Emma Beaumont, Sue Fleck, Mark Hall, Susie Hennings, Ischa Kummeling, Sara Martins, Ellen Owen-Powell, Fionna van Hooff, Livia Vivas, Ellen White, Brian Angus, Andrew Freedman, Ben Cromerty, Danielle Mercey, Sarah Fidler, Estee Torok, Abdel Babiker, Tim Peto, David Lalloo, Andrew Phillips, Robert James

Publikováno v: EClinicalMedicine, Vol 69, Iss , Pp 102457- (2024)

Summary: Background: Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI monotherapy switch strategy. Methods: Eligible participants attending 43 UK treatment centres had a

Externí odkaz: https://doaj.org/article/aefd2413e78d42f29d03d4ab013c1e5b

The diet quality of well adolescents: Do they really eat poorly?

Autor: Jacqueline Zimmerman, Alexis Santiago-Drakatos, Ronald Feinstein, Martin Fisher

Publikováno v: Global Pediatrics, Vol 6, Iss , Pp 100081- (2023)

Background: A common assumption is that adolescents have poor eating habits. However, there is minimal data regarding adolescents’ intake of macronutrients (i.e. protein, carbohydrate, and fats) and micronutrients (i.e. vitamins and minerals). In a

Externí odkaz: https://doaj.org/article/63f1c919a81347ac81a08d334b0418f3

Follow up trends among adolescent patients in a weight management program

Autor: Jennifer Shook, Amanda Mancilla, Ronald Feinstein, Stephanie Di Figlia-Peck, Martin Fisher

Publikováno v: Global Pediatrics, Vol 5, Iss , Pp 100074- (2023)

Purpose: According to the World Health Organization, obesity has nearly tripled worldwide since 1975. Childhood and adolescent obesity puts individuals at risk for many comorbidities, and interventions should begin in youth to start managing weight.

Externí odkaz: https://doaj.org/article/44911a706cd8453aa7e4ae8ceaf6ab70

How can we advance equitable, rights-based conservation?

Autor: Helen Newing, Martin Fisher, Stephanie Brittain, Justin Kenrick, E.J. Milner-Gulland

Publikováno v: Oryx, Vol 57, Pp 273-274 (2023)

Externí odkaz: https://doaj.org/article/f94ee4effb3c46a9a124e0c159bba462

Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain

Autor: Marian Galovic, Kjell Erlandsson, Tim D. Fryer, Young T. Hong, Roido Manavaki, Hasan Sari, Sarah Chetcuti, Benjamin A. Thomas, Martin Fisher, Selena Sephton, Roberto Canales, Joseph J Russell, Kerstin Sander, Erik Årstad, Franklin I. Aigbirhio, Ashley M. Groves, John S. Duncan, Kris Thielemans, Brian F. Hutton, Jonathan P. Coles, Matthias J. Koepp

Publikováno v: NeuroImage, Vol 237, Iss , Pp 118194- (2021)

Blood-based kinetic analysis of PET data relies on an accurate estimate of the arterial plasma input function (PIF). An alternative to invasive measurements from arterial sampling is an image-derived input function (IDIF). However, an IDIF provides t

Externí odkaz: https://doaj.org/article/57d2611920154aa588abda4ba324fa91