Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Martin, Doležal"'
Autor:
Hanspeter Kriesi, Edgar Grande, Martin Dolezal, Marc Helbling, Dominic Höglinger, Swen Hutter, Bruno Wüest
What are the consequences of globalization for the structure of political conflicts in Western Europe? How are political conflicts organized and articulated in the twenty-first century? And how does the transformation of territorial boundaries affect
Autor:
Petr Šlechta, Adam Anthony Needle, Ondřej Jand’ourek, Pavla Paterová, Klára Konečná, Pavel Bárta, Jiří Kuneš, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2951 (2023)
Tuberculosis remains a serious killer among infectious diseases due to its incidence, mortality, and occurrence of resistant mycobacterial strains. The challenge to discover new antimycobacterial agents forced us to prepare a series of N-(1-hydroxy-1
Externí odkaz:
https://doaj.org/article/4fa4428dfe1442afbe0a7f273e8e7758
Autor:
Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 133 (2022)
The current study is focused on the combination of pyrazinamide with 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol, which is a crucial pharmacophore of several antimicrobial agents. The use of benzoxaborole moiety could afford the formation of a spiro adduct
Externí odkaz:
https://doaj.org/article/e25ce61262bb44ff81190f948987b53c
Autor:
Michal Marko, Petr Hrubý, Martin Janča, Jakub Kříkala, Jan Hajzler, František Šoukal, Jan Vojtíšek, Martin Doležal
Publikováno v:
Materials, Vol 15, Iss 14, p 4730 (2022)
The possibility of the formation of an alkali–silicate reaction (ASR) is a crucial issue for the service life of concrete. The coexistence of key parameters such as the presence of alkalis, reactive SiO2, humidity, and temperature predetermine the
Externí odkaz:
https://doaj.org/article/1353514d854e44c08b8d6667848a687b
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells
Autor:
Jonna Tenhunen, Tomáš Kučera, Marjo Huovinen, Jenni Küblbeck, Egils Bisenieks, Brigita Vigante, Zaiga Ogle, Gunars Duburs, Martin Doležal, Ruin Moaddel, Maija Lahtela-Kakkonen, Minna Rahnasto-Rilla
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 138, Iss , Pp 111452- (2021)
Sirtuin 6 (SIRT6), a member of sirtuin family (SIRT1-7), regulates a variety of cellular processes involved in aging, metabolism, and cancer. Dysregulation of SIRT6 is widely observed in different breast cancer subtypes; however, the role and functio
Externí odkaz:
https://doaj.org/article/64ca3b992d4f4bdf97a28889ed4cf5f8
Autor:
Hanspeter Kriesi, Edgar Grande, Romain Lachat, Martin Dolezal, Simon Bornschier, Timotheos Frey
Over the past three decades the effects of globalization and denationalization have created a division between'winners'and'losers'in Western Europe. This study examines the transformation of party political systems in six countries (Austria, France,
Autor:
Ghada Bouz, Martin Doležal
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1312 (2021)
The utility of clinically available antifungals is limited by their narrow spectrum of activity, high toxicity, and emerging resistance. Antifungal drug discovery has always been a challenging area, since fungi and their human host are eukaryotes, ma
Externí odkaz:
https://doaj.org/article/32d600e85e404fd188d4bd4ee648e347
Synthesis, Biological Evaluation, and In Silico Modeling of N-Substituted Quinoxaline-2-Carboxamides
Autor:
Ghada Bouz, Sarah Bouz, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 768 (2021)
Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication. As part of our long-term res
Externí odkaz:
https://doaj.org/article/9837cdb516af40088446b84f4bb1efd2
Autor:
Ghada Bouz, Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Martin Novák, Radim Kučera, Nils-Jørgen Knudsen Dal, Federico Fenaroli, Júlia Zemanová, Martin Forbak, Jana Korduláková, Oto Pavliš, Pavla Kubíčková, Martin Doležal, Jan Zitko
Publikováno v:
ACS infectious diseases.
Apart from the SARS-CoV-2 virus, tuberculosis remains the leading cause of death from a single infectious agent according to the World Health Organization. As part of our long-term research, we prepared a series of hybrid compounds combining pyrazina
Autor:
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 25, Iss 7, p 1561 (2020)
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year. The rising resistance developed by Mycobacterium tuberculosis a
Externí odkaz:
https://doaj.org/article/cbb2f0eea373485fbfbe31ebb479da48