Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Martin, Dalziel"'
Publikováno v:
Glycobiology. 28(9)
Since the turn of the century, cancer therapy has undergone a transformation in terms of new treatment modalities and renewed optimism in achieving long-lived tumour control and even cure. This is, in large part, thanks to the widespread incorporatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571060497684aa931632435bf3ab416e
https://pubmed.ncbi.nlm.nih.gov/29800150
https://pubmed.ncbi.nlm.nih.gov/29800150
Publikováno v:
Molecular and Cellular Biology. 27:1568-1580
Cleavage and polyadenylation is an essential processing reaction required for the maturation of pre-mRNAs into stable, export- and translation-competent mature mRNA molecules. This reaction requires the assembly of a multimeric protein complex onto a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c150a1f0d5f4e9b52fbee7285a950d
https://doi.org/10.1128/mcb.01821-06
https://doi.org/10.1128/mcb.01821-06
Autor:
Max Crispin, Christopher N. Scanlan, Alessandro T. Caputo, Martin Dalziel, Laura K. Pritchard, Emma V. Beale, Iona S. Easthope, Gemma E. Seabright, Camille Bonomelli, Snezana Vasiljevic
Publikováno v:
Molecular immunology. 68(2 Pt)
Effective use of adenovirus-5 (Ad5) in cancer therapy is heavily dependent on the degree to which the virus's natural tropism can be subverted to one that favours tumour cells. This is normally achieved through either engineering of the viral fiber k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e4e0c88bd747f2e676f0ea87677217
https://pubmed.ncbi.nlm.nih.gov/26391350
https://pubmed.ncbi.nlm.nih.gov/26391350
Publikováno v:
European Journal of Biochemistry. 271:3623-3634
Several oncogenic proteins are known to influence cellular glycosylation. In particular, transfection of codon 12 point mutated H-Ras increases CMP-Neu5Ac: Galbeta1,4GlcNAc alpha2,6-sialyltransferase I (ST6Gal I) activity in rodent fibroblasts. Given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00c49ea65b30bb4b4c1513097d1d6d8c
https://doi.org/10.1111/j.1432-1033.2004.04284.x
https://doi.org/10.1111/j.1432-1033.2004.04284.x
Autor:
Michelle M. Appenheimer, Sherry A. Wuensch, Ruea-Yea Huang, Joseph T.Y. Lau, Martin Dalziel, E. V. Chandrasekaran, Yi Ping Hu, Khushi L. Matta, Paul D. Soloway
Publikováno v:
Glycobiology. 13:591-600
The synthesis of the common and well-documented Siaalpha 2,6 to Galbeta 1,4GlcNAc structure (Sia6LacNAc) is principally mediated by the sialyltransferase ST6Gal I, which is particularly highly expressed in liver, lactating mammary gland, intestinal e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a523cc6810f0a7e3658647804c82ee5
https://doi.org/10.1093/glycob/cwg066
https://doi.org/10.1093/glycob/cwg066
Publikováno v:
Science. 343(6166)
Understanding Glycosylation Glycosylation—the covalent addition of carbohydrates to proteins—is central to many biological processes. Recent advances in understanding the roles of glycans—for example, in protein folding and immune regulation—
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a6d18fe73e509d7fc305070247152c
http://ora.ox.ac.uk/objects/uuid:3f539caf-f27d-4bc6-9ed1-d98ca0deed7f
http://ora.ox.ac.uk/objects/uuid:3f539caf-f27d-4bc6-9ed1-d98ca0deed7f
Autor:
Joy Burchell, Joyce Taylor-Papadimitriou, Inka Brockhausen, Stephen Gschmeissner, Henrik Clausen, Caroline A. Whitehouse, Martin Dalziel, Tilo Schwientek, Ian McFarlane
Publikováno v:
Journal of Biological Chemistry. 276:11007-11015
In breast cancer, the O-glycans added to the MUC1 mucin are core 1- rather than core 2-based. We have analyzed whether competition by the glycosyltransferase, ST3Gal-I, which transfers sialic acid to galactose in the core 1 substrate, is key to this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abde15bc16708569443acfeba55bcd4
https://doi.org/10.1074/jbc.m006523200
https://doi.org/10.1074/jbc.m006523200
Publikováno v:
Glycobiology. 9:1003-1008
Hepatic expression of CMP-NeuAc:Gal beta 1,4GlcNAc alpha 2,6-sialyltransferase (ST6Gal I) is induced as part of the acute phase response in mammals by mechanisms that remain poorly understood. Previous work suggests that murine liver ST6Gal I mRNA co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63a72f3ed02f6f0ede3eb76c84431ff
https://doi.org/10.1093/glycob/9.10.1003
https://doi.org/10.1093/glycob/9.10.1003
Publikováno v:
Glycoconjugate Journal. 16:801-807
The lectins Sambucus nigraagglutinin (SNA) and Ricinus communisagglutinin (RCA), specific for α2,6 linked sialylation, and terminal galactose respectively were used to study the occurrence, linkage and distribution of human immunoglobulin G (IgG) si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f123cdcba29e69f6fd9de4be0e93f6
https://doi.org/10.1023/a:1007183915921
https://doi.org/10.1023/a:1007183915921
Publikováno v:
Glycoconjugate Journal. 14:407-411
ST6Gal I (β-galactoside α2,6-sialyltransferase, SiaT-1, ST6N, EC 2.4.99.1) mediates the attachment of the α2,6-sialyl linkage common on N-linked glycans. Previous work suggests substantial inter-species conservation in SIAT1, the gene encoding ST6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79da413fe9ea2ca57825dd214180b3e7
https://doi.org/10.1023/a:1018535014976
https://doi.org/10.1023/a:1018535014976