Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Martin, Connolly"'
Unveiling new genetic insights in rheumatoid arthritis for drug discovery through Taxonomy3 analysis
Autor:
Justyna Kozlowska, Neil Humphryes-Kirilov, Anastasia Pavlovets, Martin Connolly, Zhana Kuncheva, Jonathan Horner, Ana Sousa Manso, Clare Murray, J. Craig Fox, Alun McCarthy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Genetic support for a drug target has been shown to increase the probability of success in drug development, with the potential to reduce attrition in the pharmaceutical industry alongside discovering novel therapeutic targets. It is therefo
Externí odkaz:
https://doaj.org/article/584d6e712d4e4cfba6408abb7dddd1ae
Autor:
Ruth Teh, Ngaire Kerse, Avinesh Pillai, Thomas Lumley, Anna Rolleston, Tin Aung Kyaw, Martin Connolly, Joanna Broad, Elaine Monteiro, Valerie Wright-St Clair, Robert N. Doughty
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Atrial fibrillation (AF), the most common cardiac arrhythmia in the general population, has significant healthcare burden. Little is known about AF in octogenarians. Objective To describe the prevalence and incidence rate of AF in
Externí odkaz:
https://doaj.org/article/57e0ddc3276f4b7198ed17d8bca90aa0
Autor:
Cristín Ryan, Ruth Teh, Simon Moyes, Tim Wilkinson, Martin Connolly, Anna Rolleston, Mere Kepa, Ngaire Kerse
Publikováno v:
BMC Geriatrics, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Prescribing for older people is complex, and many studies have highlighted that appropriate prescribing in this cohort is not always achieved. However, the long-term effect of inappropriate prescribing on outcomes such as hospital
Externí odkaz:
https://doaj.org/article/fa57a9a4046f40c0973a95264b5e90a8
Autor:
Martin Connolly, Benjamin E Garfield, Alexi Crosby, Nick W Morrell, Stephen J Wort, Paul R Kemp
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229409 (2020)
The microRNA miR-1 is an important regulator of muscle phenotype including cardiac muscle. Down-regulation of miR-1 has been shown to occur in left ventricular hypertrophy but its contribution to right ventricular hypertrophy in pulmonary arterial hy
Externí odkaz:
https://doaj.org/article/4cf8c450ad9c45908063fa57b1de799d
Autor:
Martin Connolly, Richard Paul, Roser Farre‐Garros, Samantha A. Natanek, Susannah Bloch, Jen Lee, Jose P. Lorenzo, Harnish Patel, Cyrus Cooper, Avan A. Sayer, Stephen J. Wort, Mark Griffiths, Michael I. Polkey, Paul R. Kemp
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 2, Pp 400-416 (2018)
Abstract Background A loss of muscle mass occurs as a consequence of a range of chronic and acute diseases as well as in older age. This wasting results from an imbalance of protein synthesis and degradation with a reduction in synthesis and resistan
Externí odkaz:
https://doaj.org/article/f1d666d7cc9c48b791f9a314e78d03b6
Autor:
Richard Paul, Jen Lee, Anna V. Donaldson, Martin Connolly, Mohammad Sharif, Samantha Amanda Natanek, Ulrich Rosendahl, Michael I. Polkey, Mark Griffiths, Paul R. Kemp
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 1, Pp 119-128 (2018)
Abstract Background Loss of muscle mass and strength are important sequelae of chronic disease, but the response of individuals is remarkably variable, suggesting important genetic and epigenetic modulators of muscle homeostasis. Such factors are lik
Externí odkaz:
https://doaj.org/article/025301842fc64b8aac350e3b0666ea74
Autor:
Roy Lay-Yee, Barry J Milne, Valerie A Wright-St Clair, Joanna Broad, Tim Wilkinson, Martin Connolly, Ruth Teh, Karen Hayman, Marama Muru-Lanning, Ngaire Kerse
Publikováno v:
The Journals of Gerontology: Series B. 77:1904-1915
Objectives There is evidence that loneliness is detrimental to the subjective well-being of older adults. However, little is known on this topic for the cohort of those in advanced age (80 years or older), which today is the fastest-growing age group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abd1d1b7a091b7b7cede267aa877ee9
https://doi.org/10.1093/geronb/gbac087
https://doi.org/10.1093/geronb/gbac087
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 276 (2021)
While there have been significant advances in drug discovery for diabetes mellitus over the past couple of decades, there is an opportunity and need for improved therapies. While type 2 diabetic patients better manage their illness, many of the thera
Externí odkaz:
https://doaj.org/article/fea7af06136c4f04aeed65da8f212328
Autor:
Justyna Kozlowska, Neil Humphryes-Kirilov, Anastasia Pavlovets, Martin Connolly, Zhana Kuncheva, Jonathan Horner, Ana Sousa Manso, Clare Murray, J. Craig Fox, Alun McCarthy
Genetic support for a drug target has been shown to increase the probability of success in drug development, with the potential to reduce attrition in the pharmaceutical industry alongside discovering novel therapeutic targets. It is therefore import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d7983fe9ba76f4eb245b4e22c538b2f
https://doi.org/10.1101/2023.02.21.23286176
https://doi.org/10.1101/2023.02.21.23286176
Autor:
Carol Wham, Fiona Baggett, Ruth Teh, Simon Moyes, Mere Kēpa, Martin Connolly, Santosh Jatrana, Ngaire Kerse
Publikováno v:
Australian and New Zealand Journal of Public Health, Vol 39, Iss 4, Pp 390-395 (2015)
Abstract Objective: To investigate factors related to hospital admission for infection, specifically examining nutrient intakes of Māori in advanced age (80+ years). Method: Face‐to‐face interviews with 200 Māori (85 men) to obtain demographic,
Externí odkaz:
https://doaj.org/article/b33c0fa8f0b24f4e80ccea3ebec557ae