Biradicals based on PROXYL containing building blocks for efficient dynamic nuclear polarization in biotolerant media

Autor: Kevin Herr, Mark V. Höfler, Henrike Heise, Fabien Aussenac, Felix Kornemann, David Rosenberger, Martin Brodrecht, Marcos de Oliveira, Jr., Gerd Buntkowsky, Torsten Gutmann

Publikováno v: Journal of Magnetic Resonance Open, Vol 20, Iss , Pp 100152- (2024)

A versatile strategy for synthesizing tailored peptide based biradicals is presented. By labeling the protected amino acid hydroxyproline with PROXYL via the OH functionality and using this building block in solid phase peptide synthesis (SPPS), the

Externí odkaz: https://doaj.org/article/ef63b8ac59af471d9f6450e2c80b29fd

A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy

Autor: Kevin Herr, Max Fleckenstein, Martin Brodrecht, Mark V. Höfler, Henrike Heise, Fabien Aussenac, Torsten Gutmann, Michael Reggelin, Gerd Buntkowsky

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes. By specifically labeling the disulfide br

Externí odkaz: https://doaj.org/article/3e3cc9a70aab41148a91c6390f29b657

A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy

Autor: Kevin Herr, Fabien Aussenac, Mark V. Höfler, Henrike Heise, Gerd Buntkowsky, Max Fleckenstein, Martin Brodrecht, Michael Reggelin, Torsten Gutmann

Publikováno v: Scientific reports 11(1), 13714 (2021). doi:10.1038/s41598-021-92975-6
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes. By specifically labeling the disulfide bridge this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868988c0303addf7de7db18326b72558
http://tuprints.ulb.tu-darmstadt.de/24212/

Nuclear Magnetic Resonance and Broadband Dielectric Spectroscopy Studies on the Dynamics of Ethylene Glycol in Mesoporous Silica

Autor: Gerd Buntkowsky, Michael Vogel, Max Weigler, Melanie Reuhl, Martin Brodrecht

Publikováno v: The Journal of Physical Chemistry C. 124:20998-21012

We use nuclear magnetic resonance and broadband dielectric spectroscopy to study rotational and translational dynamics of ethylene glycol confined to mesoporous silica over wide temperature ranges....

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4beb1f3470d70fa564caf6a61e346879
https://doi.org/10.1021/acs.jpcc.0c06863

A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules

Autor: Max, Fleckenstein, Kevin, Herr, Franziska, Theiß, Stephan, Knecht, Laura, Wienands, Martin, Brodrecht, Michael, Reggelin, Gerd, Buntkowsky

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)

A specific labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the disintegrin protein barbourin in the venom of certain rattlesnakes. By specifically labeling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5a4a278bdeac0fcc76483de8f35a77