Výsledky vyhledávání - "Martin, Bilban"

Akademický článek

Nanopore sequencing unveils the complexity of the cold-activated murine brown adipose tissue transcriptome

Autor: Christoph Andreas Engelhard, Sajjad Khani, Sophia Derdak, Martin Bilban, Jan-Wilhelm Kornfeld

Publikováno v: iScience, Vol 26, Iss 8, Pp 107190- (2023)

Summary: Alternative transcription increases transcriptome complexity by expression of multiple transcripts per gene. Annotation and quantification of transcripts using short-read sequencing is non-trivial. Long-read sequencing aims at overcoming the

Externí odkaz: https://doaj.org/article/2a440377922f438ebe63ab0b1c058db5

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Akademický článek

Triple Therapy with Metformin, Ketogenic Diet, and Metronomic Cyclophosphamide Reduced Tumor Growth in MYCN-Amplified Neuroblastoma Xenografts

Autor: Luca Catalano, Sepideh Aminzadeh-Gohari, Daniela D. Weber, Rodolphe Poupardin, Victoria E. Stefan, William J. Smiles, Julia Tevini, René G. Feichtinger, Sophia Derdak, Martin Bilban, Stefan Bareswill, Markus M. Heimesaat, Barbara Kofler

Publikováno v: Metabolites, Vol 13, Iss 8, p 910 (2023)

Neuroblastoma (NB) is a childhood cancer in which amplification of the MYCN gene is the most acknowledged marker of poor prognosis. MYCN-amplified NB cells rely on both glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) for energy produc

Externí odkaz: https://doaj.org/article/fcee0e7036e44b97ab747e0b8b617e5e

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Akademický článek

The SMARCD Family of SWI/SNF Accessory Proteins Is Involved in the Transcriptional Regulation of Androgen Receptor-Driven Genes and Plays a Role in Various Essential Processes of Prostate Cancer

Autor: Iris E. Ertl, Robert Brettner, Hannah Kronabitter, Thomas Mohr, Sophia Derdak, Markus Jeitler, Martin Bilban, Nathalie Garstka, Shahrokh F. Shariat

Publikováno v: Cells, Vol 12, Iss 1, p 124 (2022)

Previous studies have demonstrated an involvement of chromatin-remodelling SWI/SNF complexes in the development of prostate cancer, suggesting both tumor suppressor and oncogenic activities. SMARCD1/BAF60A, SMARCD2/BAF60B, and SMARCD3/BAF60C are mutu

Externí odkaz: https://doaj.org/article/218cab34a57f4e719a0b0b6632e36fc7

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Akademický článek

A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids

Autor: Marie-Sophie Narzt, Ionela-Mariana Nagelreiter, Olga Oskolkova, Valery N. Bochkov, Julie Latreille, Maria Fedorova, Zhixu Ni, Fernando J. Sialana, Gert Lubec, Manuel Filzwieser, Maria Laggner, Martin Bilban, Michael Mildner, Erwin Tschachler, Johannes Grillari, Florian Gruber

Publikováno v: Redox Biology, Vol 20, Iss , Pp 467-482 (2019)

Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators would be generated in primary human keratinocytes (KC) upon exposure to ultraviolet A light

Externí odkaz: https://doaj.org/article/e753d9b2b48f41d7bdaec8829ec54c48

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Akademický článek

Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis

Autor: Anna Fenzl, Oana Cristina Kulterer, Katrin Spirk, Goran Mitulović, Rodrig Marculescu, Martin Bilban, Sabina Baumgartner-Parzer, Alexandra Kautzky-Willer, Lukas Kenner, Jorge Plutzky, Loredana Quadro, Florian W. Kiefer

Publikováno v: Molecular Metabolism, Vol 42, Iss , Pp 101088- (2020)

Objective: Transformation of white into brown fat (“browning”) reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic pro

Externí odkaz: https://doaj.org/article/50ed6e3fe9f9437e9d60ef6205e466cc

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Akademický článek

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA,

Externí odkaz: https://doaj.org/article/54a402f6076e4b0fbbecca1070ed468d

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Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH

Publikováno v: Journal of Hepatology, 77(5), 1373-1385. Elsevier Science

BACKGROUND & AIMS: Previous single-cell RNA-sequencing analyses have shown that Trem2-expressing macrophages are present in the liver during obesity, non-alcoholic steatohepatitis (NASH) and cirrhosis. Herein, we aimed to functionally characterize th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc35e9ab4202dfa69601804f0eecf88
https://doi.org/10.1016/j.jhep.2022.06.004

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Akademický článek

Pumilio2-deficient mice show a predisposition for epilepsy

Autor: Philipp Follwaczny, Rico Schieweck, Therese Riedemann, Antonia Demleitner, Tobias Straub, Anna H. Klemm, Martin Bilban, Bernd Sutor, Bastian Popper, Michael A. Kiebler

Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 11, Pp 1333-1342 (2017)

Epilepsy is a neurological disease that is caused by abnormal hypersynchronous activities of neuronal ensembles leading to recurrent and spontaneous seizures in human patients. Enhanced neuronal excitability and a high level of synchrony between neur

Externí odkaz: https://doaj.org/article/95ea08f8accd47d68f9720a3cc42f368

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