Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Martin, Baumgartner"'
Autor:
Syeda Afshan, Yu Gang Kim, Jesse Mattsson, Malin Åkerfelt, Pirkko Härkönen, Martin Baumgartner, Matthias Nees
Publikováno v:
Cancer Medicine, Vol 13, Iss 18, Pp n/a-n/a (2024)
Abstract Background Inhibition of androgen receptor (AR) signaling is the main treatment strategy in advanced prostate cancer (PCa). A subset of castration resistant prostate cancer (CRPC) bypasses the AR blockade by increased fibroblast growth facto
Externí odkaz:
https://doaj.org/article/50bad1de5a494228b47b0e9e0c70543a
Autor:
Martin Baumgartner, Karl Kreiner, Aaron Lauschensky, Bernhard Jammerbund, Klaus Donsa, Dieter Hayn, Fabian Wiesmüller, Lea Demelius, Robert Modre-Osprian, Sabrina Neururer, Gerald Slamanig, Sarah Prantl, Luca Brunelli, Bernhard Pfeifer, Gerhard Pölzl, Günter Schreier
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionThe potential for secondary use of health data to improve healthcare is currently not fully exploited. Health data is largely kept in isolated data silos and key infrastructure to aggregate these silos into standardized bodies of knowledg
Externí odkaz:
https://doaj.org/article/f0a66e9315ce4949bf67f5cd10a25b85
Autor:
Martin Baumgartner, Karl Kreiner, Fabian Wiesmüller, Dieter Hayn, Christian Puelacher, Günter Schreier
Publikováno v:
Future Internet, Vol 16, Iss 8, p 281 (2024)
Background: The recent rise of large language models has triggered renewed interest in medical free text data, which holds critical information about patients and diseases. However, medical free text is also highly sensitive. Therefore, de-identifica
Externí odkaz:
https://doaj.org/article/4106c93784784af5af91dd18292ff231
Leveraging molecular structure and bioactivity with chemical language models for de novo drug design
Autor:
Michael Moret, Irene Pachon Angona, Leandro Cotos, Shen Yan, Kenneth Atz, Cyrill Brunner, Martin Baumgartner, Francesca Grisoni, Gisbert Schneider
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Generative Deep Learning holds promise for mining the unexplored “chemical universe” for new drugs. Here, the authors demonstrate the de novo design of phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors for the PI3K/Akt pathway in human tumor ce
Externí odkaz:
https://doaj.org/article/813fd08e95d44abfaa961a2900ee404a
Autor:
Jessica Migliavacca, Buket Züllig, Charles Capdeville, Michael A. Grotzer, Martin Baumgartner
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Analysis of the MAP4K4-STRN3 cooperation in medulloblastoma reveals its opposing regulation of Hippo activation and tissue invasion in cancer.
Externí odkaz:
https://doaj.org/article/8a4ebb155dbe4dac9740109c6f219634
Autor:
Martin Baumgartner, Christian Fazekas, Klaus-Martin Simonic, Christian Vajda, Katrin Michlmayr-Brand, Gernot Lecaks, Katharina Steininger-Kaar, Clemens Gangl, Georg Dorffner
Publikováno v:
Zeitschrift für Hochschulentwicklung, Vol 18, Iss Sonderheft Hochschullehre (2023)
Die Digitalisierung verändert alle Lebensbereiche und damit auch die Anforderungen an zukünftige Ärztinnen und Ärzte. In einem gemeinsamen Ansatz haben interuniversitäre und interdisziplinäre Arbeitsgruppen der österreichischen öffentlichen m
Externí odkaz:
https://doaj.org/article/c415c99574a247079eb15b59fb4fb996
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The finely tuned integration of intra- and extracellular cues by components of the mitogen-activated protein kinase (MAPK) signaling pathways controls the mutually exclusive phenotypic manifestations of uncontrolled growth and tumor cell disseminatio
Externí odkaz:
https://doaj.org/article/6caf5fb8ff754f6985115f4fe4587b28
Publikováno v:
Medical Education Online, Vol 27, Iss 1 (2022)
Digitalisation is changing all areas of our daily life. This changing environment requires new competences from physicians in all specialities. This study systematically surveyed the knowledge, attitude, and interests of medical students. These resul
Externí odkaz:
https://doaj.org/article/418809c07601498f8ddf6a5bab116238
Autor:
Marc Thomas Schönholzer, Jessica Migliavacca, Elena Alvarez, Karthiga Santhana Kumar, Anuja Neve, Alexandre Gries, Min Ma, Michael A. Grotzer, Martin Baumgartner
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 470-483 (2020)
Aberrantly activated kinase signaling pathways drive invasion and dissemination in medulloblastoma (MB). A majority of tumor-promoting kinase signaling pathways feed into the mitogen-activated protein kinase (MAPK) extracellular regulated kinase (ERK
Externí odkaz:
https://doaj.org/article/e9b22d0b85e14ffb9251063d3d027f1e
Autor:
Dr. Dominique Bruns, Dr. Daniel Merk, Dr. Karthiga Santhana Kumar, PD Dr. Martin Baumgartner, Prof. Dr. Gisbert Schneider
Publikováno v:
ChemistryOpen, Vol 8, Iss 10, Pp 1303-1308 (2019)
Abstract Constructive machine learning aims to create examples from its learned domain which are likely to exhibit similar properties. Here, a recurrent neural network was trained with the chemical structures of known cell‐migration modulators. Thi
Externí odkaz:
https://doaj.org/article/7ae3e2e4ed7148e1aa1b6498568ac75c