Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Martijn van de Bunt"'
Autor:
Jason M. Torres, Vibe Nylander, Han Sun, Martijn van de Bunt, Damien J. Downes, Mark I. McCarthy, Jim R. Hughes, Anna L. Gloyn
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Resolving causal genes for type 2 diabetes at loci implicated by genome-wide association studies (GWAS) requires integrating functional genomic data from relevant cell types. Chromatin features in endocrine cells of the pancreatic islet a
Externí odkaz:
https://doaj.org/article/887578fcac7042d7bd19c922142bef24
Autor:
Vanessa Isabell Jurtz, Grethe Skovbjerg, Casper Gravesen Salinas, Urmas Roostalu, Louise Pedersen, Jacob Hecksher-Sørensen, Bidda Rolin, Michael Nyberg, Martijn van de Bunt, Camilla Ingvorsen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Complications of atherosclerosis are the leading cause of morbidity and mortality worldwide. Various genetically modified mouse models are used to investigate disease trajectory with classical histology, currently the preferred methodology t
Externí odkaz:
https://doaj.org/article/307dce623c614724b179921559a4ac86
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Autor:
Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew A. Brown, Michael R. Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Paul Johnson, Ulrika Krus, Patrick E. MacDonald, Anubha Mahajan, Jocelyn E. Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I. Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S. Collins, Karen L. Mohlke, Anna L. Gloyn, Laura J. Scott, Emmanouil T. Dermitzakis, Leif Groop, Stephen C. J. Parker, Mark I. McCarthy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mechanistic inference following GWAS is hampered by the lack of tissue-specific transcriptomic resources. Here the authors combine genetic variants predisposing to type 2 diabetes with human pancreatic islet RNA-seq data. They identify 7741 islet exp
Externí odkaz:
https://doaj.org/article/1e9cd2a221bf4b5fa3193842e74efdfa
Autor:
Elizabeth Haythorne, Maria Rohm, Martijn van de Bunt, Melissa F. Brereton, Andrei I. Tarasov, Thomas S. Blacker, Gregor Sachse, Mariana Silva dos Santos, Raul Terron Exposito, Simon Davis, Otto Baba, Roman Fischer, Michael R. Duchen, Patrik Rorsman, James I. MacRae, Frances M. Ashcroft
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a
Externí odkaz:
https://doaj.org/article/e58a88780c484df287e145eadffc1041
Autor:
Juan Fernández-Tajes, Kyle J. Gaulton, Martijn van de Bunt, Jason Torres, Matthias Thurner, Anubha Mahajan, Anna L. Gloyn, Kasper Lage, Mark I. McCarthy
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Genome-wide association studies (GWAS) have identified several hundred susceptibility loci for type 2 diabetes (T2D). One critical, but unresolved, issue concerns the extent to which the mechanisms through which these diverse sign
Externí odkaz:
https://doaj.org/article/6be6fea4470f48a6bbf9cc44fdf798cf
Autor:
Joely A. Kellard, Nils J.G. Rorsman, Thomas G. Hill, Sarah L. Armour, Martijn van de Bunt, Patrik Rorsman, Jakob G. Knudsen, Linford J.B. Briant
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101021- (2020)
Objectives: Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD). Methods: Female mice expressing the Ca2+ ind
Externí odkaz:
https://doaj.org/article/ad9a94c5162e4167af86f21b28811f7f
Autor:
Lena K Hansson, Rasmus Borup Hansen, Sune Pletscher-Frankild, Rudolfs Berzins, Daniel Hvidberg Hansen, Dennis Madsen, Sten B Christensen, Malene Revsbech Christiansen, Ulrika Boulund, Xenia Asbæk Wolf, Sonny Kim Kjærulff, Martijn van de Bunt, Søren Tulin, Thomas Skøt Jensen, Rasmus Wernersson, Jan Nygaard Jensen
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233956 (2020)
BackgroundSurveying the scientific literature is an important part of early drug discovery; and with the ever-increasing amount of biomedical publications it is imperative to focus on the most interesting articles. Here we present a project that high
Externí odkaz:
https://doaj.org/article/97287a9d68b2414aad61ea290a973c33
Autor:
Matthias Thurner, Martijn van de Bunt, Jason M Torres, Anubha Mahajan, Vibe Nylander, Amanda J Bennett, Kyle J Gaulton, Amy Barrett, Carla Burrows, Christopher G Bell, Robert Lowe, Stephan Beck, Vardhman K Rakyan, Anna L Gloyn, Mark I McCarthy
Publikováno v:
eLife, Vol 7 (2018)
Human genetic studies have emphasised the dominant contribution of pancreatic islet dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the islet epigenome has constrained efforts to define the molecular mechanisms med
Externí odkaz:
https://doaj.org/article/db690f11107845c38640398b02088b1a
Autor:
Valborg Gudmundsdottir, Helle Krogh Pedersen, Karla Viviani Allebrandt, Caroline Brorsson, Nienke van Leeuwen, Karina Banasik, Anubha Mahajan, Christopher J Groves, Martijn van de Bunt, Adem Y Dawed, Andreas Fritsche, Harald Staiger, Annemarie M C Simonis-Bik, Joris Deelen, Mark H H Kramer, Axel Dietrich, Thomas Hübschle, Gonneke Willemsen, Hans-Ulrich Häring, Eco J C de Geus, Dorret I Boomsma, Elisabeth M W Eekhoff, Jorge Ferrer, Mark I McCarthy, Ewan R Pearson, Ramneek Gupta, Søren Brunak, Leen M 't Hart
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189886 (2018)
Glucagon-like peptide 1 (GLP-1) stimulated insulin secretion has a considerable heritable component as estimated from twin studies, yet few genetic variants influencing this phenotype have been identified. We performed the first genome-wide associati
Externí odkaz:
https://doaj.org/article/162474e50a644cc39421953ec62c7c5c
Autor:
Martijn van de Bunt, Jocelyn E Manning Fox, Xiaoqing Dai, Amy Barrett, Caleb Grey, Lei Li, Amanda J Bennett, Paul R Johnson, Raymond V Rajotte, Kyle J Gaulton, Emmanouil T Dermitzakis, Patrick E MacDonald, Mark I McCarthy, Anna L Gloyn
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005694 (2015)
The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes (T2D) predisposition and glucose homeostasis. However, the specific gene
Externí odkaz:
https://doaj.org/article/91ef871658694086b9a889a097fc114f