Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Martijn van Rosmalen"'
Autor:
David J.J. de Gorter, Alexandre Deshiere, Arjen Kramer, Martijn van Rosmalen, Franziska Mortensen, Cecile Geuijen
Publikováno v:
Cancer Research. 83:4999-4999
The HGF/c-MET pathway is frequently upregulated in tumors that are resistant to EGFR tyrosine kinase inhibitors. MCLA-129 is an antibody-dependent cellular cytotoxicity (ADCC) enhanced Biclonics® that targets epidermal growth factor receptor (EGFR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eede5d2e2947851237561022c3855dda
https://doi.org/10.1158/1538-7445.am2023-4999
https://doi.org/10.1158/1538-7445.am2023-4999
Autor:
David J. de Gorter, Marie O'Connor, Alexandre Deshiere, Martijn van Rosmalen, Szabolcs Fatrai, Jeroen Lammerts van Bueren, Cecile A. Geuijen
Publikováno v:
Cancer Research. 82:336-336
Introduction: MCLA-129 is an ADCC-enhanced IgG1 bispecific antibody that targets epidermal growth factor receptor (EGFR) and c-MET. The HGF/c-MET pathway is frequently upregulated in tumors that are resistant to EGFR tyrosine kinase inhibitors (TKIs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9dc8bb44c6dfd7ee67bd1d5c334ea3
https://doi.org/10.1158/1538-7445.am2022-336
https://doi.org/10.1158/1538-7445.am2022-336
Autor:
Qingyu Shu, Liang Deng, Rinse Klooster, Wenxin Xu, Cecile Geuijen, John de Kruif, Li Mao, Wei Liu, Martijn van Rosmalen, Mark Throsby, Tristan Gallenne, David J. de Gorter, Mario Di Matteo, Alexandre Deshiere, Christian Wohn, Massimiliano Mazzone, Berina Eppink
Publikováno v:
Cancer Research. 81:952-952
MCLA-129 is an ADCC-enhanced common light chain bispecific human IgG1 Biclonics® antibody specifically targeting the receptor tyrosine kinases EGFR and c-MET. It inhibits activation and downstream signaling of EGFR and c-MET induced by their respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02db516a6d3a502f8247e3d00df0acc7
https://doi.org/10.1158/1538-7445.am2021-952
https://doi.org/10.1158/1538-7445.am2021-952
Publikováno v:
Biochemistry, 56(50), 6565-6574. American Chemical Society
Flexible polypeptide linkers composed of glycine and serine are important components of engineered multidomain proteins. We have previously shown that the conformational properties of Gly-Gly-Ser repeat linkers can be quantitatively understood by com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51403187bb67be5c9c12f4e5461cf75f
https://research.tue.nl/en/publications/5b6c1fe3-d41f-4492-b48b-09102fee160d
https://research.tue.nl/en/publications/5b6c1fe3-d41f-4492-b48b-09102fee160d
Autor:
Ardjan J. van der Linden, Tfa Tom de Greef, D Wanders, Maarten Merkx, Nathalie Hendrikse, Pascal A. Pieters, Bmg Brian Janssen, M Martijn van Rosmalen
Publikováno v:
Journal of Biological Chemistry, 292(4), 1477-1489. American Society for Biochemistry and Molecular Biology Inc.
Meditopes are cyclic peptides that bind in a specific pocket in the antigen-binding fragment of a therapeutic antibody such as cetuximab. Provided their moderate affinity can be enhanced, meditope peptides could be used as specific non-covalent and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046f036ba4d75a4f99ae2dc06fb8e1ce
https://doi.org/10.1074/jbc.m116.764225
https://doi.org/10.1074/jbc.m116.764225
Autor:
Susann K. J. Ludwig, Maarten Merkx, M Martijn van Rosmalen, Yan Ni, Daan F. M. Vervoort, Remco Arts
Publikováno v:
Analytical Chemistry, 90(5), 3592-3599. American Chemical Society
Analytical Chemistry
Analytical Chemistry
Monitoring the levels of therapeutic antibodies in individual patients would allow patient-specific dose optimization, with the potential for major therapeutic and financial benefits. Our group recently developed a new platform of bioluminescent sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830a78fe4a2b447fb78591434dd720e2
https://research.tue.nl/nl/publications/ae8b19be-bddf-44fa-a28e-0025c2197306
https://research.tue.nl/nl/publications/ae8b19be-bddf-44fa-a28e-0025c2197306
Publikováno v:
Angewandte Chemie-International Edition, 127(8), 2560-2563. Wiley
Oligonucleotide-based molecular circuits offer the exciting possibility to introduce autonomous signal processing in biomedicine, synthetic biology, and molecular diagnostics. Here we introduce bivalent peptide–DNA conjugates as generic, noncovalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c8eceb22076a73d9b453ba37bfae97
https://doi.org/10.1002/anie.201410779
https://doi.org/10.1002/anie.201410779
Autor:
Mario Lebendiker, Assaf Friedler, Martijn van Rosmalen, Tsafi Danieli, Guy Mayer, Anat Iosub Amir
Publikováno v:
Scientific Reports
We present a possible molecular basis for the opposite activity of two homologues proteins that bind similar ligands and show that this is achieved by fine-tuning of the interaction interface. The highly homologous ASPP proteins have opposite roles i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3792dc0ba34ec86a30ac13f80b779f72
https://doi.org/10.1038/srep11629
https://doi.org/10.1038/srep11629