Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Martijn Wehrens"'
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113284- (2023)
Summary: The inherent stochasticity of metabolism raises a critical question for understanding homeostasis: are cellular processes regulated in response to internal fluctuations? Here, we show that, in E. coli cells under constant external conditions
Externí odkaz:
https://doaj.org/article/db25480c13674746b3836d3228458c3c
Autor:
Martijn Wehrens, Anne E. de Leeuw, Maya Wright-Clark, Joep E.C. Eding, Cornelis J. Boogerd, Bas Molenaar, Petra H. van der Kraak, Diederik W.D. Kuster, Jolanda van der Velden, Michelle Michels, Aryan Vink, Eva van Rooij
Publikováno v:
Cell Reports, 39(6). Cell Press
Cell Reports, 39(6):110809. Cell Press
Wehrens, M, de Leeuw, A E, Wright-Clark, M, Eding, J E C, Boogerd, C J, Molenaar, B, van der Kraak, P H, Kuster, D W D, van der Velden, J, Michels, M, Vink, A & van Rooij, E 2022, ' Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy ', Cell Reports, vol. 39, no. 6, 110809 . https://doi.org/10.1016/j.celrep.2022.110809
Cell Reports, 39(6):110809. Cell Press
Wehrens, M, de Leeuw, A E, Wright-Clark, M, Eding, J E C, Boogerd, C J, Molenaar, B, van der Kraak, P H, Kuster, D W D, van der Velden, J, Michels, M, Vink, A & van Rooij, E 2022, ' Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy ', Cell Reports, vol. 39, no. 6, 110809 . https://doi.org/10.1016/j.celrep.2022.110809
Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is characterized by unexplained segmental hypertrophy that is usually most pronounced in the septum. While sarcomeric gene mutations are often the genetic basis for HCM, the mechanisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f075b3620a94a6d61c3751ad132e989
https://pure.knaw.nl/portal/en/publications/78b14421-b0e9-4720-963d-1de6f43fc415
https://pure.knaw.nl/portal/en/publications/78b14421-b0e9-4720-963d-1de6f43fc415
Publikováno v:
Nature Cardiovascular Research. 1:798-799
Autor:
Tara Moens, Cornelis J. Boogerd, Eva van Rooij, Marie-José Goumans, Martijn Wehrens, Sebastiaan J. van Kampen, Arwa Kohela, Anke M. Smits, Bas Molenaar, Jantine Monshouwer-Kloots, J. Peter van Tintelen, Ilaria Perini
Publikováno v:
Science Translational Medicine, 13(612). AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 13(612). American Association for the Advancement of Science (AAAS)
Science Translational Medicine, 13(612). American Association for the Advancement of Science (AAAS)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder often caused by pathogenic variants in desmosomal genes and characterized by progressive fibrotic and fat tissue accumulation in the heart. The cellular origin and responsible molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f97536b366756c6d26b96926339a355
http://hdl.handle.net/1887/3276198
http://hdl.handle.net/1887/3276198
Publikováno v:
Current Opinion in Systems Biology. 8:131-136
Advances in our ability to zoom in on single cells have revealed striking heterogeneity within isogenic populations. Attention has so far focussed predominantly on underlying stochastic variability in regulatory pathways and downstream differentiatio
Autor:
Tara Moens, Arjan Vink, Sebastiaan J. van Kampen, Bas Molenaar, Jantine Monshouwer-Kloots, Eva van Rooij, Martijn Wehrens, Huei-Sheng Vincent Chen, Arwa Kohela
Publikováno v:
Circulation Research. 125
Arrhythmogenic cardiomyopathy (ACM) is an inherited disease mainly caused by desmosomal gene mutations and characterized by myocardial loss, replacement with fibro-fatty tissue, arrhythmias and sudden cardiac death. To date, it is unclear which cell
Autor:
Nils B. Becker, Kazunari Kaizu, Marileen Dogterom, Joris Paijmans, Thomas Miedema, Laurens Bossen, Pieter Rein ten Wolde, Koichi Takahashi, Thomas R. Sokolowski, Martijn Wehrens
Publikováno v:
Journal of Chemical Physics
Biochemical reactions typically occur at low copy numbers, but at once in crowded and diverse environments. Space and stochasticity therefore play an essential role in biochemical networks. Spatial-stochastic simulations have become a prominent tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73b2c008f9cf9182fb7fc00116d66ef
Publikováno v:
The Journal of Chemical Physics. 141:205102
Clustering of molecules on biological membranes is a widely observed phenomenon. In some cases, such as the clustering of Ras proteins on the membranes of mammalian cells, proper cell signaling is critically dependent on the maintenance of these clus