Výsledky vyhledávání - "Martijn S. Bijker"

Design and development of synthetic peptide vaccines: past, present and future

Autor: Martijn S. Bijker, Rienk Offringa, Cornelis J. M. Melief, Sjoerd H. van der Burg

Publikováno v: Expert Review of Vaccines. 6:591-603

Synthetic peptide vaccines aiming at the induction of a protective CD8(+) T-cell response against infectious or malignant diseases are widely used in the clinic but, despite their success in animal models, they do not yet live up to their promise in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300ad303d584c002e2d287cfbf5436bf
https://doi.org/10.1586/14760584.6.4.591

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Spontaneous tumor rejection by cbl-b–deficient CD8+ T cells

Autor: Karin Loser, Manu Rangachari, Josef M. Penninger, Cornelis J. M. Melief, Teiji Wada, Stefanie Loeser, Martijn S. Bijker, Sjoerd H. van der Burg, Stefan Beissert

Publikováno v: The Journal of Experimental Medicine

The concept of tumor surveillance implies that specific and nonspecific components of the immune system eliminate tumors in the early phase of malignancy. Understanding the biochemical mechanisms of tumor immunosurveillance is of paramount significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41eaf7cac493fa9461c564add35a6d4
https://doi.org/10.1084/jem.20061699

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Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists

Autor: Sjoerd H. van der Burg, Marij J. P. Welters, Martijn S. Bijker, Susan J. F. van den Eeden, Rienk Offringa, Cornelis J. M. Melief, Kees L. M. C. Franken

Publikováno v: Vaccine. 25:1379-1389

A systematic comparison of the immunostimulatory capacity of TLR 2, 3, 4, 5, 7 and 9 agonists and an agonistic CD40-specific antibody was performed in a single long peptide vaccination model. All adjuvants activated DC in vitro but not all induced a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d78e90996a36eff6821ff8961b440f1
https://doi.org/10.1016/j.vaccine.2006.10.049

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Improved peptide vaccine strategies, creating synthetic artificial infections to maximize immune efficacy

Autor: R. Offringa, Martijn S. Bijker, Sjoerd H. van der Burg, Marij J. P. Welters, Cornelis J. M. Melief

Publikováno v: Advanced Drug Delivery Reviews. 58:916-930

Soon after it was realized that T-cells recognize their target antigens as small protein fragments or peptides presented by MHC molecules at the cell surface, these peptide epitopes have been tried as vaccines. Human testing of such vaccines, althoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2a61d389b740cabe381856b085aee0
https://doi.org/10.1016/j.addr.2005.11.003

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Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity

Autor: Ernie Yulyaningsih, Laurent Pangon, Martijn S. Bijker, Shu Lin, Amanda Sainsbury, Yan C. Shi, Laurence Macia, Herbert Herzog, Fabienne Mackay, Lei Zhang, Amy D. Nguyen, Shane T. Grey

Publikováno v: Diabetes

Recruitment of activated immune cells into white adipose tissue (WAT) is linked to the development of insulin resistance and obesity, but the mechanism behind this is unclear. Here, we demonstrate that Y1 receptor signaling in immune cells controls i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644a4d65de17b45586b438801079ad75
https://pubmed.ncbi.nlm.nih.gov/23011592

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Peripheral-specific y2 receptor knockdown protects mice from high-fat diet-induced obesity

Autor: Hui Zhang, Lesley Castillo, Ernie Yulyaningsih, Ronaldo F. Enriquez, Laurence Macia, Paul A. Baldock, Herbert Herzog, Shu Lin, Jackie Lau, Yan-Chuan Shi, Amanda Sainsbury, Amy D. Nguyen, Aygul Aljanova, Lei Zhang, Martijn S. Bijker

Publikováno v: Obesity (Silver Spring, Md.). 19(11)

Y2 receptors, particularly those in the brain, have been implicated in neuropeptide Y (NPY)-mediated effects on energy homeostasis and bone mass. Recent evidence also indicates a role for Y2 receptors in peripheral tissues in this process by promotin

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https://pubmed.ncbi.nlm.nih.gov/21546930

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The neuropeptide Y system: pathophysiological and therapeutic implications in obesity and cancer

Autor: Martijn S. Bijker, Lei Zhang, Herbert Herzog

Publikováno v: Pharmacologytherapeutics. 131(1)

The neuropeptide Y (NPY) system--comprising of neuropeptide Y, peptide YY, pancreatic polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and y6)--is well known for its role in the regulation of energy homeostasis and

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https://pubmed.ncbi.nlm.nih.gov/21439311

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Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation

Autor: Susan J. F. van den Eeden, Rienk Offringa, Sjoerd H. van der Burg, Cornelis J. M. Melief, Martijn S. Bijker, Kees L. M. C. Franken

Publikováno v: European journal of immunology. 38(4)

Anti-tumor vaccines consisting of extended CTL peptides in combination with CpG-ODN were shown to be superior to those comprising minimal CTL epitopes and CpG-ODN, in that they elicit stronger effector CTL responses with greater tumoricidal potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4916259f2df59a60d9b553f11db0658
https://pubmed.ncbi.nlm.nih.gov/18350546

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CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity

Autor: Sjoerd H. van der Burg, Martijn S. Bijker, Cornelis J. M. Melief, Rienk Offringa, Susan J. F. van den Eeden, Kees L. M. C. Franken

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 179(8)

Therapeutic vaccination trials, in which patients with cancer were vaccinated with minimal CTL peptide in oil-in-water formulations, have met with limited success. Many of these studies were based on the promising data of mice studies, showing that v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1be7355074fb26858638b4d30bcef88
https://pubmed.ncbi.nlm.nih.gov/17911588

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Distinct Uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells

Autor: Gosse J. Adema, Hans J. Tanke, Jimmy J. Weterings, Selina Khan, Jan W. Drijfhout, Martijn S. Bijker, Hermen S. Overkleeft, Thorbald van Hall, Ferry Ossendorp, Gijsbert A. van der Marel, Dmitri V. Filippov, Sjoerd H. van der Burg, Cornelis J. M. Melief

Publikováno v: Journal of Biological Chemistry, 282, 29, pp. 21145-59
Journal of Biological Chemistry, 282(29), 21145-21159
Journal of Biological Chemistry, 282, 21145-59
Journal of Biological Chemistry

Contains fulltext : 52377.pdf (Publisher’s version ) (Open Access) Covalent conjugation of Toll-like receptor ligands (TLR-L) to synthetic antigenic peptides strongly improves antigen presentation in vitro and T lymphocyte priming in vivo. These mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61c243e7cf6f904d5f6f96ec836bac0
https://hdl.handle.net/1887/49979

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