Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Martijn Rooseboom"'
Autor:
Martijn Rooseboom, Neslihan Aygun Kocabas, Colin North, Richard James Radcliffe, Lawrence Segal
Publikováno v:
Regulatory Toxicology and Pharmacology. 141:105387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9fc9dc405000b5cad2ddb9e031e2ac2
https://doi.org/10.1016/j.yrtph.2023.105387
https://doi.org/10.1016/j.yrtph.2023.105387
Autor:
Barbara M. A. van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C. A. Onderwater, Paul Jennings
Publikováno v:
Van Vugt-Lussenburg, B M A, Capinha, L, Reinen, J, Rooseboom, M, Kranendonk, M, Onderwater, R C A & Jennings, P 2022, ' "Commandeuring" Xenobiotic Metabolism : Advances in Understanding Xenobiotic Metabolism ', Chemical Research in Toxicology, vol. 35, no. 7, pp. 1184–1201 . https://doi.org/10.1021/acs.chemrestox.2c00067
The understanding of how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determine the impact of the chemical and its metabolites to the (human) organism. This is part of the research and educational disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df41a96a33afe60a99553de9285d7df4
https://hdl.handle.net/1871.1/eab2130d-7bc3-41bf-88db-8831940315e9
https://hdl.handle.net/1871.1/eab2130d-7bc3-41bf-88db-8831940315e9
Autor:
Colin M. North, Martijn Rooseboom, Neslihan Aygun Kocabas, Nicholas Synhaeve, Richard James Radcliffe, Lawrence Segal
Publikováno v:
Regulatory Toxicology and Pharmacology. 140:105380
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d8e0c46bb395b6f144aa0b5ac68e72a
https://doi.org/10.1016/j.yrtph.2023.105380
https://doi.org/10.1016/j.yrtph.2023.105380
Autor:
M. Wehr, Martijn Rooseboom, Peter J. Boogaard, Sylvia Escher, Andreas Karwath, Satinder S. Sarang
Publikováno v:
Regulatory Toxicology and Pharmacology 128 (2022)
Regulatory Toxicology and Pharmacology, 128
Regulatory Toxicology and Pharmacology, 128
Respiratory irritation is an important human health endpoint in chemical risk assessment. There are two established modes of action of respiratory irritation, 1) sensory irritation mediated by the interaction with sensory neurons, potentially stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990415982a930ccf95beafb772f00041
https://doi.org/10.1016/j.yrtph.2021.105089
https://doi.org/10.1016/j.yrtph.2021.105089
Autor:
Francesca Tencalla, Martijn Rooseboom, Neslihan Aygun Kocabas, Thomas Petry, Nicholas Synhaeve, Erik Rushton
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 126
Dicyclopentadiene (DCPD) is an olefinic hydrocarbon which is manufactured and imported into the European Union (EU) at greater than 1000 tons per year. Concerns related to fetotoxic effects observed in reproductive toxicity studies at high doses led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f592288f46d7fc1265faa078658df07f
https://pubmed.ncbi.nlm.nih.gov/34478800
https://pubmed.ncbi.nlm.nih.gov/34478800
Autor:
Stephen D. Williams, Abigail Dalzell, Colin M. North, Martijn Rooseboom, Neslihan Aygun Kocabas, A. Robert Schnatter
Occupational exposure to benzene at levels of 10 ppm or more has been associated with increased risk of acute myeloid leukaemia (AML). The mode of action (MOA) for AML development leading to mortality is anticipated to include multiple earlier key ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ee2d5fa3a7c20ac944e479aaddc6f5
Autor:
Frank Faulhammer, A. Robert Schnatter, Johannes J. Twisk, Stephen D. Williams, Peter J. Boogaard, Martijn Rooseboom, Viktorija Ostapenkaite, Neslihan Aygun Kocabas, Abigail Dalzell, Erik Rushton, Colin M. North
This paper derives an occupational exposure limit for benzene using quality assessed data. Seventy-seven genotoxicity and 36 haematotoxicity studies in workers were scored for study quality with an adapted tool based on that of Vlaanderen et al 2008
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ae1487ea8412ee07e2baa21b66f840
Autor:
Neslihan Aygun Kocabas, Martijn Rooseboom, Stephen D. Williams, Frank Faulhammer, A. Robert Schnatter, Colin M. North
Understanding the Mode of Action (MOA) for a chemical can help guide decisions in development of Occupational Exposure Limits (OELs). Where sufficient information exists, it can provide the OEL developer the basis for selecting either a health-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722062c6b59b86deae87837b8a56a967
Autor:
Michael L. Shuler, Delilah F. G. Hendriks, Betty C. Hakkert, Alicia Paini, Peter M.J. Bos, Bart Spee, Marije Strikwold, Ian Sorrell, Paul Jennings, Ans Punt, Huan Yang, Hans Bouwmeester, Bas J. Blaauboer, Minne B. Heringa, Meike van der Zande, Rosalinde Masereeuw, Martijn Rooseboom, Ad A. C. M. Peijnenburg, Mathieu Vinken, Andries D. van der Meer, Sandra Coecke, Nynke I. Kramer, Sibylle Neuhoff
Publikováno v:
ALTEX.
For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d506975c9be110527fa44b2ace726336
https://doi.org/10.14573/altex.2003242
https://doi.org/10.14573/altex.2003242
Autor:
J.-W. Lankhaar, M van der Voet, E. Poppelaars, Martijn Rooseboom, M. Corradi, R. Currie, M. Steijaert, M. Wildwater, Cyrille Krul, V. van Noort, Roland J. Pieters, D. Bhalla, Marc Teunis, T. Verbeke, G. Keizer
Publikováno v:
Toxicology Letters. 350:S68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7cc2f0a54fd78c204a421bd3fe81b71
https://doi.org/10.1016/s0378-4274(21)00407-0
https://doi.org/10.1016/s0378-4274(21)00407-0