Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Martijn R. Molenaar"'
Autor:
Martijn R. Molenaar, Mohammed Shahraz, Jeany Delafiori, Andreas Eisenbarth, Måns Ekelöf, Luca Rappez, Theodore Alexandrov
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Imaging mass spectrometry (MS) is becoming increasingly applied for single-cell analyses. Multiple methods for imaging MS-based single-cell metabolomics were proposed, including our recent method SpaceM. An important step in imaging MS-based single-c
Externí odkaz:
https://doaj.org/article/50e60aa0d5a74a509e9d81234f7d2b81
Autor:
Maya W. Haaker, Hedwig S. Kruitwagen, Arie B. Vaandrager, Martin Houweling, Louis C. Penning, Martijn R. Molenaar, Monique E. vanWolferen, Loes A. Oosterhoff, Bart Spee, J. Bernd Helms
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 34, Iss 1, Pp 132-138 (2020)
Abstract Background Hepatic lipidosis is increasing in incidence in the Western world, with cats being particularly sensitive. When cats stop eating and start utilizing their fat reserves, free fatty acids (FFAs) increase in blood, causing an accumul
Externí odkaz:
https://doaj.org/article/9e1ab320d6b74ca9bb639a32d61656eb
Autor:
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 822-830 (2017)
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies demonstrate the p
Externí odkaz:
https://doaj.org/article/1b75311bbf3843328b88a26d9590e37a
Autor:
Aike Jeucken, Martijn R. Molenaar, Chris H.A. van de Lest, Jeroen W.A. Jansen, J. Bernd Helms, Jos F. Brouwers
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1597-1606.e2 (2019)
Summary: Lipid membranes are the border between living cells and their environments. The membrane’s lipid composition defines fluidity, thickness, and protein activity and is controlled by the intricate actions of lipid gene-encoded enzymes. Howeve
Externí odkaz:
https://doaj.org/article/f569b30fc8574fd287c9fae147654f80
Autor:
Maidina Tuohetahuntila, Martijn R. Molenaar, Bart Spee, Jos F. Brouwers, Martin Houweling, Arie B. Vaandrager, J. Bernd Helms
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 7, Pp 1162-1174 (2016)
Hepatic stellate cell (HSC) activation is a critical step in the development of chronic liver disease. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerol (TAG), cholesteryl esters (CEs), and retinyl esters (REs). Here
Externí odkaz:
https://doaj.org/article/e9fd671f5e4a44a8a318a75e8e2a5506
Publikováno v:
Cells, Vol 9, Iss 10, p 2244 (2020)
Lipids play Jekyll and Hyde in the liver. On the one hand, the lipid-laden status of hepatic stellate cells is a hallmark of healthy liver. On the other hand, the opposite is true for lipid-laden hepatocytes—they obstruct liver function. Neglected
Externí odkaz:
https://doaj.org/article/aa964a4d6a66416bbbb4550c7e6c1ab9
Autor:
Zhixu Ni, Michele Wölk, Geoff Jukes, Karla Mendivelso Espinosa, Robert Ahrends, Lucila Aimo, Jorge Alvarez-Jarreta, Simon Andrews, Robert Andrews, Alan Bridge, Geremy C. Clair, Matthew J. Conroy, Eoin Fahy, Caroline Gaud, Laura Goracci, Jürgen Hartler, Nils Hoffmann, Dominik Kopczyinki, Ansgar Korf, Andrea F. Lopez-Clavijo, Adnan Malik, Jacobo Miranda Ackerman, Martijn R. Molenaar, Claire O’Donovan, Tomáš Pluskal, Andrej Shevchenko, Denise Slenter, Gary Siuzdak, Martina Kutmon, Hiroshi Tsugawa, Egon L. Willighagen, Jianguo Xia, Valerie B. O’Donnell, Maria Fedorova
Publikováno v:
Nature Methods, 20, 193-204. Nature Publishing Group
Nat Methods
Nat Methods
Recent progress in mass spectrometry (MS) lipidomics has led to a rapid proliferation of studies across biology and biomedicine and facilitating important discoveries. These generate extremely large raw datasets requiring sophisticated tailored solut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4703f5cdf9d5a93e8e3707020004fffc
https://doi.org/10.1038/s41592-022-01710-0
https://doi.org/10.1038/s41592-022-01710-0
Autor:
Albert Pérez-Martí, Suresh Ramakrishnan, Jiayi Li, Aurelien Dugourd, Martijn R Molenaar, Luigi R De La Motte, Kelli Grand, Anis Mansouri, Mélanie Parisot, Soeren S Lienkamp, Julio Saez-Rodriguez, Matias Simons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd31cb6cb5c13e531f3f6c11d19cadc4
https://doi.org/10.7554/elife.74391.sa2
https://doi.org/10.7554/elife.74391.sa2
Autor:
Jiayi Li, Suresh Ramakrishnan, Kelli Grand, Soeren S. Lienkamp, Aurelien Dugourd, Anis Mansouri, Mélanie Parisot, Albert Pérez-Martí, Martijn R. Molenaar, Matias Simons, Luigi R. De La Motte, Julio Saez-Rodriguez
In diabetic patients, dyslipidemia frequently contributes to organ damage such as diabetic kidney disease (DKD). DKD is associated with excessive renal deposition of triacylglycerol (TAG) in lipid droplets (LD). Yet, it is unclear whether LDs play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc332f4452229615b6f550baa9210ca1
https://doi.org/10.1101/2021.09.07.459360
https://doi.org/10.1101/2021.09.07.459360
Autor:
Jennifer E, Kyle, Lucila, Aimo, Alan J, Bridge, Geremy, Clair, Maria, Fedorova, J Bernd, Helms, Martijn R, Molenaar, Zhixu, Ni, Matej, Orešič, Denise, Slenter, Egon, Willighagen, Bobbie-Jo M, Webb-Robertson
Publikováno v:
Metabolomics : Official journal of the Metabolomic Society. 17(6)
Improvements in mass spectrometry (MS) technologies coupled with bioinformatics developments have allowed considerable advancement in the measurement and interpretation of lipidomics data in recent years. Since research areas employing lipidomics are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ba7a42b386e76cf79ddc6e570d3fe60
https://pubmed.ncbi.nlm.nih.gov/34091802
https://pubmed.ncbi.nlm.nih.gov/34091802