Výsledky vyhledávání - "Martijn L. Bakker"

Akademický článek

Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.

Autor: Kamini Kunasegaran, Victor Ho, Ted H-T Chang, Duvini De Silva, Martijn L Bakker, Vincent M Christoffels, Alexandra M Pietersen

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110191 (2014)

The transcriptional repressor Tbx3 is involved in lineage specification in several tissues during embryonic development. Germ-line mutations in the Tbx3 gene give rise to Ulnar-Mammary Syndrome (comprising reduced breast development) and Tbx3 is requ

Externí odkaz: https://doaj.org/article/4b372e78434c49caa89df327d62af04f

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Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

Autor: Vincent M. Christoffels, Stéphane Zaffran, Sonia Stefanovic, Corrie de Gier-de Vries, Arie O. Verkerk, Karel van Duijvenboden, Vincent Wakker, Bas J. Boukens, Martijn L. Bakker, Vincent W. W. van Eif

Publikováno v: Development (Cambridge, England), 146(8). Company of Biologists Ltd
Development
Development, 2019, 146 (8), ⟨10.1242/dev.173161⟩

International audience; The rate of contraction of the heart relies on proper development and function of the sinoatrial node, which consists of a small heterogeneous cell population, including Tbx3(+) pacemaker cells. Here, we have isolated and char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0440d342d1a697593fb66db6b5c71325
https://pure.amc.nl/en/publications/transcriptome-analysis-of-mouse-and-human-sinoatrial-node-cells-reveals-a-conserved-genetic-program(8d44e29e-4f43-47b0-8f96-3526f71b4c87).html

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The Cardiac Pacemaker and Conduction System Develops From Embryonic Myocardium that Retains Its Primitive Phenotype

Autor: Martijn L. Bakker, Antoon F.M. Moorman, Vincent M. Christoffels

Publikováno v: Journal of cardiovascular pharmacology, 56(1), 6-15. Lippincott Williams and Wilkins

Disorders of the cardiac conduction system occur frequently and may cause life-threatening arrhythmias requiring medication or electronic pacemaker implantation. Repair or regeneration of conduction system components is currently not possible due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2286cc49148d3adc133d2e5fd5255e29
https://doi.org/10.1097/fjc.0b013e3181e775d3

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The atrioventricular node: origin, development, and genetic program

Autor: Martijn L. Bakker, Vincent M. Christoffels, Antoon F.M. Moorman

Publikováno v: Trends in cardiovascular medicine. 20(5):164-171

The sinus node generates the electrical impulse, which spreads rapidly over both atria, causing them to contract simultaneously. In the normal heart, a layer of connective tissue electrically insulates the atria and ventricles. The only pathway that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b17e07f5e4ea6551893c776b4dd793
https://doi.org/10.1016/j.tcm.2011.02.001

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Gene expression profiling of the forming atrioventricular node using a novel tbx3-based node-specific transgenic reporter

Autor: Vincent M. Christoffels, Henk P. J. Buermans, Antoon F.M. Moorman, Peter A C 't Hoen, Martijn L. Bakker, Arie O. Verkerk, Vincent Wakker, Danielle E.W. Clout, Thomas Horsthuis, Janynke F. Brons

Publikováno v: Circulation research, 105(1), 61-69. Lippincott Williams and Wilkins

The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV nodal myocardium–specific reporter mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2cb5d6a1d4e366acc8b0873707cae1
https://doi.org/10.1161/circresaha.108.192443

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Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Autor: E. E. Verheijck, Phil Barnett, Janynke F. Brons, Martijn L. Bakker, Arie O. Verkerk, Antoon F.M. Moorman, Jan H. Ravesloot, Willem M.H. Hoogaars, Frederik J. de Lange, Danielle E.W. Clout, Angela Engel, L.Y. Elaine Wong, Vincent M. Christoffels, Vincent Wakker

Publikováno v: Genes & development, 21(9), 1098-1112. Cold Spring Harbor Laboratory Press

The sinoatrial node initiates the heartbeat and controls the rate and rhythm of contraction, thus serving as the pacemaker of the heart. Despite the crucial role of the sinoatrial node in heart function, the mechanisms that underlie its specification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8b66855f7f95c7ea0c8dc999e056c0
https://doi.org/10.1101/gad.416007

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Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium

Autor: Martijn L. Bakker, Vincent M. Christoffels, Kamini Kunasegaran, Duvini De Silva, Victor Ho, Ted H-. T. Chang, Alexandra M Pietersen

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e110191 (2014)
PLoS ONE, 9(10). Public Library of Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2921b75237c111ba139263a697de1a9f
https://doi.org/10.1371/journal.pone.0110191

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Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

Autor: Connie R. Bezzina, Phil Barnett, L.Y. Elaine Wong, Peter A C 't Hoen, Vincent Wakker, Malou van den Boogaard, Jeroen Bakkers, Federico Tessadori, Vincent M. Christoffels, Martijn L. Bakker, Lisa K. Dreizehnter

Publikováno v: Journal of Clinical Investigation, 122(7), 2519-2530
Journal of Clinical Investigation, 122, 2519-30
Journal of Clinical Investigation, 122(7), 2519-2530. The American Society for Clinical Investigation
Journal of Clinical Investigation, 122, 7, pp. 2519-30
Journal of Clinical Investigation; Vol 122
Journal of clinical investigation, 122(7), 2519-2530. The American Society for Clinical Investigation
Journal of Clinical Investigation

Contains fulltext : 108002.pdf (Publisher’s version ) (Open Access) The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5430a8648b1ebcd983b371407cd53ce4
http://hdl.handle.net/1887/98533

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T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells

Autor: Antoon F.M. Moorman, Martijn L. Bakker, Willem M.H. Hoogaars, Jurgen Seppen, Gerard J.J. Boink, Vincent M. Christoffels, Bas J. Boukens, A. Dénise den Haan, Peter A C 't Hoen, Henk P. J. Buermans, Jacques M.T. de Bakker, Arie O. Verkerk, Malou van den Boogaard, Hanno L. Tan

Publikováno v: Cardiovascular Research, 94, 439-49
Cardiovascular Research, 94(3), 439-449
Cardiovascular research, 94(3), 439-449. Oxford University Press
Cardiovascular Research, 94, 3, pp. 439-49

Item does not contain fulltext AIM: Treatment of disorders of the sinus node or the atrioventricular node requires insights into the molecular mechanisms of development and homoeostasis of these pacemaker tissues. In the developing heart, transcripti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e154b2661892cf8c981c2b833e9294
https://pubmed.ncbi.nlm.nih.gov/22523095

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Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

Autor: Martin Tristani-Firouzi, Deborah U. Frank, Anne M. Moon, R. Michael Burr, Kandis Carter, William A. Coetzee, Martijn L. Bakker, Kirk R. Thomas, Michael J. Bamshad, Vincent M. Christoffels

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 109(3), E154-E163. National Academy of Sciences

TBX3 is critical for human development: mutations in TBX3 cause congenital anomalies in patients with ulnar-mammary syndrome. Data from mice and humans suggest multiple roles for Tbx3 in development and function of the cardiac conduction system. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b6fb84312865ddc167ae91746893ae
https://pubmed.ncbi.nlm.nih.gov/22203979

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