Výsledky vyhledávání - "Martijn L, Manson"

Akademický článek

The impact of CYP2C19 genotype on phenoconversion by concomitant medication

Autor: Laura M. de Jong, Soukayna Boussallami, Elena Sánchez-López, Martin Giera, Maarten E. Tushuizen, Menno Hoekstra, Lukas J. A. C. Hawinkels, Robert Rissmann, Jesse J. Swen, Martijn L. Manson

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted. Drug-drug-interaction

Externí odkaz: https://doaj.org/article/dfd4b7aa0cba4a3db6f51c0bbc61c879

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Akademický článek

PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice

Autor: Laura M. de Jong, Zhengzheng Zhang, Yvette den Hartog, Timothy J. P. Sijsenaar, Renata Martins Cardoso, Martijn L. Manson, Thomas Hankemeier, Peter W. Lindenburg, Daniela C. F. Salvatori, Miranda Van Eck, Menno Hoekstra

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Protein arginine methyltransferase 3 (PRMT3) is a co-activator of liver X receptor capable of selectively modulating hepatic triglyceride synthesis. Here we investigated whether pharmacological PRMT3 inhibition can diminish the hepatic steat

Externí odkaz: https://doaj.org/article/2acc68e974784fab8a54729f6409f243

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A systematic review on disease-drug-drug interactions with immunomodulating drugs

Autor: Laura M. de Jong, Sylvia D. Klomp, Nicoline Treijtel, Robert Rissmann, Jesse J. Swen, Martijn L. Manson

Publikováno v: British Journal of Clinical Pharmacology, 88(10), 4387-4402
British Journal of Clinical Pharmacology, 88(10), 4387-4402. WILEY

Aim: Use of immunomodulating therapeutics for immune-mediated inflammatory diseases may cause disease-drug-drug interactions (DDDIs) by reversing inflammation-driven alterations in the metabolic capacity of cytochrome P450 enzymes. European Medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93343a4a2817e269defa8b78634b35e9
https://hdl.handle.net/1887/3483880

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Phenoconversion of cytochrome P450 metabolism: a systematic review

Autor: Henk-Jan Guchelaar, Martijn L. Manson, Sylvia D Klomp, Jesse J. Swen

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, 9(9), 2890. MDPI} {AG
Journal of Clinical Medicine, 9(9). MDPI
Journal of Clinical Medicine, Vol 9, Iss 2890, p 2890 (2020)

Phenoconversion is the mismatch between the individual’s genotype-based prediction of drug metabolism and the true capacity to metabolize drugs due to nongenetic factors. While the concept of phenoconversion has been described in narrative reviews,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e2a980f3c66a8f50fa06f3b1299e8d
https://doi.org/10.3390/jcm9092890

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IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways

Autor: Martijn L, Manson, Jesper, Säfholm, Anna, James, Anna-Karin, Johnsson, Per, Bergman, Mamdoh, Al-Ameri, Ann-Charlotte, Orre, Carina, Kärrman-Mårdh, Sven-Erik, Dahlén, Mikael, Adner

Publikováno v: The Journal of allergy and clinical immunology. 145(3)

Specific inflammatory pathways are indicated to contribute to severe asthma, but their individual involvement in the development of airway hyperresponsiveness remains unexplored.This experimental study in human small bronchi aimed to provide insight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1518be51a3be65c5370459df5eee8f1e
https://pubmed.ncbi.nlm.nih.gov/31805312

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Mannitol triggers mast cell-dependent contractions of human small bronchi and prostacyclin bronchoprotection

Autor: Sven-Erik Dahlén, Ann-Charlotte Orre, Johan Raud, Mamdoh Al-Ameri, Johan Bood, Mikael Adner, Martijn L. Manson, Jesper Säfholm

Publikováno v: Journal of Allergy and Clinical Immunology, 144(4), 984-992
Journal of Allergy and Clinical Immunology

BACKGROUND:Clinical research supports that exercise-induced bronchoconstriction (EIB) is caused by hyperosmolar triggering of mast cells. The reaction can be mimicked by inhalation of mannitol, but it has paradoxically previously not been possible to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8023c18fc18610624a75010c9139e90
http://hdl.handle.net/1887/138269

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Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for Pharmacogenetics

Autor: Laura M. de Jong, Martijn L. Manson, Wim Jiskoot, Jesse J. Swen

Publikováno v: Genes
Genes, 11(12). MDPI
Genes, Vol 11, Iss 1509, p 1509 (2020)

Personalized medicine strives to optimize drug treatment for the individual patient by taking into account both genetic and non-genetic factors for drug response. Inflammation is one of the non-genetic factors that has been shown to greatly affect th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee9da2bb641ca8d39f6c264544c5625
https://doi.org/10.3390/genes11121509

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The TLR7 agonist imiquimod induces bronchodilation via a nonneuronal TLR7-independent mechanism: a possible role for quinoline in airway dilation

Autor: Mikael Adner, Olivia Larsson, Magnus Starkhammar, Susanna Kumlien Georén, Lars-Olaf Cardell, Barbara Fuchs, Martijn L. Manson

Publikováno v: American Journal of Physiology, 310(11), L1121-L1129

Toll-like receptor (TLR) 7 agonists are known to reduce allergic airway inflammation. Their recently reported ability to rapidly relax airways has further increased their interest in the treatment of pulmonary disease. However, the mechanisms behind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b045f289f76fd4b1ce10d8cd46379500
https://doi.org/10.1152/ajplung.00288.2015

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Long-acting β2-adrenoceptor agonists enhance glucocorticoid receptor (GR)-mediated transcription by gene-specific mechanisms rather than generic effects via GR

Autor: Dong Yan, Robert Newton, Mark A. Giembycz, Mohammed O. Altonsy, Christopher F. Rider, Anthony N. Gerber, Suharsh Shah, Sarah Sasse, Mahmoud M. Mostafa, Anna Miller-Larsson, Carina Kärrman-Mårdh, Martijn L. Manson

Publikováno v: Mol Pharmacol

In asthma, the clinical efficacy of inhaled corticosteroids (ICSs) is enhanced by long-acting β(2)-adrenoceptor agonists (LABAs). ICSs, or more accurately, glucocorticoids, promote therapeutically relevant changes in gene expression, and, in primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11efd5956ee68134fdedd5446a798bfc
https://hdl.handle.net/1887/3200938

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Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle

Autor: Mamdoh Al-Ameri, Mikael Adner, Jesper Säfholm, Karl Swärd, Sven-Erik Dahlén, Martijn L. Manson, Ann-Charlotte Orre, Anna James, Per Bergman

Publikováno v: European Journal of Pharmacology. 740:302-311

Taste-sensing type 2 receptors (TAS2Rs) have been implicated in extraoral functions. Airway smooth muscle expresses TAS2Rs and is strongly relaxed by TAS2R agonists. We hypothesised that TAS2R agonists might affect vascular smooth muscle as well. Mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7037d000a3d3f0e353f2242f279bbbe
https://doi.org/10.1016/j.ejphar.2014.07.005

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