Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Martijn J Moné"'
1
Akademický článek
Design principles of nuclear receptor signaling: how complex networking improves signal transduction
Autor: Alexey N Kolodkin, Frank J Bruggeman, Nick Plant, Martijn J Moné, Barbara M Bakker, Moray J Campbell, Johannes P T M van Leeuwen, Carsten Carlberg, Jacky L Snoep, Hans V Westerhoff
Publikováno v: Molecular Systems Biology, Vol 6, Iss 1, Pp 1-14 (2010)
Abstract The topology of nuclear receptor (NR) signaling is captured in a systems biological graphical notation. This enables us to identify a number of ‘design’ aspects of the topology of these networks that might appear unnecessarily complex or
Externí odkaz: https://doaj.org/article/f2b210373e1d4c64b882cf37bd83e411
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2
Akademický článek
Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism.
Autor: Katja N Rybakova, Frank J Bruggeman, Aleksandra Tomaszewska, Martijn J Moné, Carsten Carlberg, Hans V Westerhoff
Publikováno v: PLoS Computational Biology, Vol 11, Iss 4, p e1004236 (2015)
Activation of eukaryotic transcription is an intricate process that relies on a multitude of regulatory proteins forming complexes on chromatin. Chromatin modifications appear to play a guiding role in protein-complex assembly on chromatin. Together,
Externí odkaz: https://doaj.org/article/7a423745c54b4acf83b02400e4a836f8
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3
NAM-supported read-across: From case studies to regulatory guidance in safety assessment
Autor: Martijn J Moné, Takashi Yamada, Costanza Rovida, Andrew White, Bob van de Water, Leon van Aerts, Susanne Hougaard Bennekou, Grace Patlewicz, Matthias Herzler, Lidka Maslankiewicz, Sylvia Escher, Dinant Kroese, Hennicke Kamp, Nisha S. Sipes
Publikováno v: ALTEX
Rovida, C, Escher, S E, Herzler, M, Bennekou, S H, Kamp, H, Kroese, D E, Maslankiewicz, L, Moné, M J, Patlewicz, G, Sipes, N, Van Aerts, L, White, A, Yamada, T & Van de Water, B 2021, ' NAM-supported read-across : From case studies to regulatory guidance in safety assessment ', A L T E X. Alternatives to Animal Experimentation, vol. 38, no. 1, pp. 140-150 . https://doi.org/10.14573/altex.2010062
ALTEX : Alternatives to Animal Experimentation, 38(1), 140-150
The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project. To bring this forward, EU-ToxRisk partners convened a workshop in close collaboration with regul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1118af309a713f8d5af8271a36a175f8
https://doi.org/10.14573/altex.2010062
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4
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid
Autor: Nanette G, Vrijenhoek, Matthias M, Wehr, Steven J, Kunnen, Lukas S, Wijaya, Giulia, Callegaro, Martijn J, Moné, Sylvia E, Escher, Bob, Van de Water
Publikováno v: ALTEX : Alternatives to Animal Experimentation
ALTEX
Chemical read-across is commonly evaluated without particular knowledge of the biological mechanisms leading to observed adverse outcomes in vivo. Integrating data that indicate shared modes of action in humans will strengthen read-across cases. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e2256765890ee51972b634035aa790
http://hdl.handle.net/1887/3279365
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5
Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
Autor: Samantha V. Llewellyn, Ali Kermanizadeh, Victor Ude, Nicklas Raun Jacobsen, Gillian E. Conway, Ume-Kulsoom Shah, Marije Niemeijer, Martijn J. Moné, Bob van de Water, Shambhu Roy, Wolfgang Moritz, Vicki Stone, Gareth J.S. Jenkins, Shareen H. Doak
Publikováno v: Toxicology in Vitro
Toxicology In Vitro, 85, 105473
To reduce, replace, and refine in vivo testing, there is increasing emphasis on the development of more physiologically relevant in vitro test systems to improve the reliability of non-animal-based methods for hazard assessment. When developing new a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3280abd30bca97acfa6499c0f19f06ed
https://cronfa.swan.ac.uk/Record/cronfa61299
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6
In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment
Autor: Marije Niemeijer, Gareth J.S. Jenkins, Shareen H. Doak, Penny Nymark, Martijn J Moné, Bob van de Water, Samantha V. Llewellyn, Gillian E. Conway
Publikováno v: Small, 17(15)
Small
Whilst the liver possesses the ability to repair and restore sections of damaged tissue following acute injury, prolonged exposure to engineered nanomaterials (ENM) may induce repetitive injury leading to chronic liver disease. Screening ENM cytotoxi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c75f9e3c82711ece87d641c9548085d
https://doi.org/10.1002/smll.202006055
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7
Modeling and Simulation Tools: From Systems Biology to Systems Medicine
Autor: Brett G. Olivier, Maciej J. Swat, Martijn J. Moné
Publikováno v: Systems Medicine
Systems Medicine. Springer
Methods in Molecular Biology ISBN: 9781493932825
Modeling is an integral component of modern biology. In this chapter we look into the role of the model, as it pertains to Systems Medicine, and the software that is required to instantiate and run it. We do this by comparing the development, impleme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09625dca55dc527df129fe8ef972aca6
https://research.wur.nl/en/publications/modeling-and-simulation-tools-from-systems-biology-to-systems-med
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8
Modeling and Simulation Tools: From Systems Biology to Systems Medicine
Autor: Brett G, Olivier, Maciej J, Swat, Martijn J, Moné
Publikováno v: Methods in molecular biology (Clifton, N.J.). 1386
Modeling is an integral component of modern biology. In this chapter we look into the role of the model, as it pertains to Systems Medicine, and the software that is required to instantiate and run it. We do this by comparing the development, impleme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01dacdef345b308484dea17a1e5e27aa
https://pubmed.ncbi.nlm.nih.gov/26677194
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10
Systems Biology towards life in silico: mathematics of the control of living cells
Autor: Barbara M. Bakker, Martijn J. Moné, Hanna M. Härdin, Alexey Kolodkin, Hans van Leeuwen, Jacky L. Snoep, Klaas Krab, Marco Eijken, Frank J. Bruggeman, Riaan Conradie, Stephen J. Wilkinson, Katja N. Rybakova, Jan H. van Schuppen, Hans V. Westerhoff
Publikováno v: Westerhoff, H V, Kolodkin, A N, Conradie, R, Wilkinson, S J, Bruggeman, F J, Krab, K, Schuppen, J H, Hardin, H M, Bakker, B M, Mone, M J, Rybakova, E N, Eijken, M, van Leeuwen, J P & Snoep, J L 2009, ' Systems Biology towards life in silico: mathematics of the control of living cells. ', Journal of Mathematical Biology, vol. 58, pp. 7-34 . https://doi.org/10.1007/s00285-008-0160-8
Journal of Mathematical Biology, 58, 7-34. Springer Verlag
Journal of Mathematical Biology, 58(1-2), 7-34. Springer-Verlag
Westerhoff, H V, Kolodkin, A, Conradie, R, Wilkinson, S J, Bruggeman, F J, Krab, K, van Schuppen, J H, Hardin, H, Bakker, B M, Moné, M J, Rybakova, K N, Eijken, M, van Leeuwen, H J P & Snoep, J L 2009, ' Systems biology towards life in silico : mathematics of the control of living cells ', Journal of Mathematical Biology, vol. 58, no. 1-2, pp. 7-34 . https://doi.org/10.1007/s00285-008-0160-8
Systems Biology is the science that aims to understand how biological function absent from macromolecules in isolation, arises when they are components of their system. Dedicated to the memory of Reinhart Heinrich, this paper discusses the origin and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36889fd3574c120799520fceae6b637d
https://hdl.handle.net/1871/27365
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