Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Martijn H den Brok"'
Autor:
Stefan Nierkens, Tonke K Raaijmakers, Renske J E van den Bijgaart, Martijn H den Brok, Melissa Wassink, Annemarie de Graaf, Jori A Wagenaars, Marleen Ansems, Gert Jan Scheffer, Gosse J Adema
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Tumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendritic cells (D
Externí odkaz:
https://doaj.org/article/1d10133bed404d1486826c6a9612772a
Autor:
Stefan Nierkens, Tonke K Raaijmakers, Renske J E van den Bijgaart, Martijn H den Brok, Melissa Wassink, Annemarie de Graaf, Jori A Wagenaars, Marleen Ansems, Gert Jan Scheffer, Gosse J Adema
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Externí odkaz:
https://doaj.org/article/2925983f95f6425387b1893973b6e866
Autor:
Stefan Nierkens, Martijn H den Brok, Thijs Roelofsen, Jori A L Wagenaars, Carl G Figdor, Theo J Ruers, Gosse J Adema
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8368 (2009)
BackgroundThe TLR9 agonist CpG is increasingly applied in preclinical and clinical studies as a therapeutic modality to enhance tumor immunity. The clinical application of CpG appears, however, less successful than would be predicted from animal stud
Externí odkaz:
https://doaj.org/article/9b71579ac2cc4de8ab648b64648303bf
Autor:
Gosse J. Adema, Martijn H. den Brok, Torben Heise, Johan van der Vlag, Louis Boon, Victor R. Bloemendal, Jasper J. van Gemst, Melissa Wassink, Sarah M. Weischer, Natasja Balneger, Thomas J. Boltje, Christian Büll
Fig. S1 Effect of intratumoral injections with 20 mg/kg S1 Ac53FaxNeu5Ac on B16-F10WT tumor growth. Fig. S2 Responsiveness of melanoma and neuroblastoma cells to Ac53FaxNeu5Ac. S2 Fig. S3 10 mg/kg Ac53FaxNeu5Ac injections are well tolerated. S3 Fig.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b1f780de0d86d541bdfeccb10edc87
https://doi.org/10.1158/0008-5472.22419500
https://doi.org/10.1158/0008-5472.22419500
Autor:
Gosse J. Adema, Theo J.M. Ruers, Carl G. Figdor, Mary E. Morgan, Erik Bennink, Oliver M. Grauer, Roger P.M. Sutmuller, Martijn H. den Brok, Stefan Nierkens
Immunostimulatory cytidyl guanosyl (CpG) motifs are of great interest as cancer vaccine adjuvants. They act as potent inducers of Th1 responses, including the activation of cytotoxic CD8+ T lymphocytes (CTL). Whereas animal models have provided clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6acde5be3d811fbbdff3f293500688
https://doi.org/10.1158/0008-5472.c.6497448
https://doi.org/10.1158/0008-5472.c.6497448
Autor:
Gosse J. Adema, Theo J.M. Ruers, Carl G. Figdor, Mary E. Morgan, Erik Bennink, Oliver M. Grauer, Roger P.M. Sutmuller, Martijn H. den Brok, Stefan Nierkens
Supplementary Figure 1 from In vivo Colocalization of Antigen and CpG within Dendritic Cells Is Associated with the Efficacy of Cancer Immunotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f0ec8abacaf11452c061e5ba670676
https://doi.org/10.1158/0008-5472.22374435.v1
https://doi.org/10.1158/0008-5472.22374435.v1
Autor:
Lisa G M, Huis In 't Veld, Nataschja I, Ho, Melisssa, Wassink, Martijn H, den Brok, Gosse J, Adema
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(5)
Saponin-based adjuvants (SBAs) are promising new adjuvants that stand out as they not only enforce CD4 + T cell-mediated immunity and antibody responses, but also induce an unprecedented level of antigen cross-presentation by dendritic cells (DC) and
Autor:
Gert Jan Scheffer, Martijn H. den Brok, Tonke K. Raaijmakers, Melissa Wassink, Gosse J. Adema, Stefan Nierkens, Marleen Ansems, Jori A. L. Wagenaars, Renske J.E. van den Bijgaart, Annemarie M.A. de Graaf
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer, 8
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer, 8, 1
Journal for Immunotherapy of Cancer, 8
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer, 8, 1
BackgroundTumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendritic cells (DC
Autor:
Rutger H. T. Koornstra, Christian U. Blank, Martijn H. den Brok, Sandra van Wilpe, Niven Mehra, Jan Willem B. de Groot, Winald R. Gerritsen, Jolanda De Vries
Publikováno v:
Oncoimmunology, 9
OncoImmunology, Vol 9, Iss 1 (2020)
Oncoimmunology, 9, 1
Oncoimmunology
OncoImmunology, Vol 9, Iss 1 (2020)
Oncoimmunology, 9, 1
Oncoimmunology
Contains fulltext : 218885.pdf (Publisher’s version ) (Open Access) Lactate dehydrogenase (LDH) levels are inversely related with response to checkpoint inhibitors. Elevated LDH levels are the product of enhanced glycolytic activity of the tumor an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8351607ccad9ce6033cbabffc9da9ced
http://hdl.handle.net/2066/218885
http://hdl.handle.net/2066/218885
Autor:
Torben Heise, Barbara M. Schulte, Thomas J. Boltje, Estel Collado-Camps, Gosse J. Adema, Esther D. Kers-Rebel, Jonas Nørskov Søndergaard, Martijn H. den Brok, Christian Büll
Publikováno v:
Immunology and Cell Biology, 95, 4, pp. 408-415
Immunology and Cell Biology, 95, 408-415
Immunology and Cell Biology, 95, 408-415
Contains fulltext : 177820.pdf (Publisher’s version ) (Closed access) Sialic acid sugars cover the surface of dendritic cells (DCs) and have been suggested to impact several aspects of DC biology. Research into the role of sialic acids in DCs, howe