Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Martijn H Brugman"'
Autor:
Saskia Kohlscheen, Sabine Wintterle, Adrian Schwarzer, Christel Kamp, Martijn H Brugman, Daniel C Breuer, Guntram Büsche, Christopher Baum, Ute Modlich
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131866 (2015)
Thrombopoietin (Thpo) signals via its receptor Mpl and regulates megakaryopoiesis, hematopoietic stem cell (HSC) maintenance and post-transplant expansion. Mpl expression is tightly controlled and deregulation of Thpo/Mpl-signaling is linked to hemat
Externí odkaz:
https://doaj.org/article/cec0456968844460ab0b515e4ac5f129
Autor:
Machteld M Tiemessen, Miranda R M Baert, Tom Schonewille, Martijn H Brugman, Farbod Famili, Daniela C F Salvatori, Jules P P Meijerink, Ugur Ozbek, Hans Clevers, Jacques J M van Dongen, Frank J T Staal
Publikováno v:
PLoS Biology, Vol 10, Iss 11, p e1001430 (2012)
The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(-/-) mice have previously been characterized and show developmental blocks at the CD4-CD8- double negative (DN) to CD4+
Externí odkaz:
https://doaj.org/article/d01e65ab97f9410c99e8a9d22ab94577
Autor:
Teng-Cheong Ha, Boris Fehse, Olga S. Kustikova, Violetta Dziadek, Maike Stahlhut, Gabi Paul, Martijn H. Brugman, Axel Schambach, Michael Rothe, Christopher Baum, Michael A. Morgan
Publikováno v:
Human Gene Therapy. 32:458-472
Retroviral insertional mutagenesis (RIM) is both a relevant risk in gene therapy and a powerful tool for identifying genes that enhance the competitiveness of repopulating hematopoietic stem and pr...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23a7fa9758eafa17e3fdb169e9acc9db
https://doi.org/10.1089/hum.2019.344
https://doi.org/10.1089/hum.2019.344
Autor:
P. Hardwicke, Christopher J. Sampson, Martijn H. Brugman, Cindy Jung, Yu Hua Chen, Bernadette Mouzon, Eva Puschmann, Conrad A. Vink, Stephen R.C. Warr, Paul S. Carter, Ashkenaz Richard, Steven J. Howe, Alessia Boiti, Peter Archibald, Vanesa M. Marinova, Michela Marongiu, Sean Baker, Mao Xiang Chen, Sabine Johnson, Tarik Senussi, Miriam Mendez-Tavio, Nathan P. Sweeney, Celeste Pallant, Marlene Carmo, David Grose, Pijus Brazauskas, Anthony Shillings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 47-57 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Stable suspension producer cell lines for the production of vesicular stomatitis virus envelope glycoprotein (VSVg)-pseudotyped lentiviral vectors represent an attractive alternative to current widely used production methods based on transient transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6603ce57bb9f5dfdfffc4d0f96421e
http://www.sciencedirect.com/science/article/pii/S2329050120301777
http://www.sciencedirect.com/science/article/pii/S2329050120301777
Autor:
David San Leon Granado, Machteld M. Tiemessen, Laura Garcia-Perez, Karin Pike-Overzet, Frank J. T. Staal, Farbod Famili, Marja C.J.A. van Eggermond, Haoyu Wu, Martijn Cordes, Jihed Chouaref, Lucia Daxinger, Martijn H. Brugman
Publikováno v:
Science Advances, 6(31). AMER ASSOC ADVANCEMENT SCIENCE
Science Advances
Science Advances
The major transcription factors that regulate how stem cells commit to become T lymphocytes are functionally defined
T cell factor 1 (Tcf1) is the first T cell–specific protein induced by Notch signaling in the thymus, leading to the activatio
T cell factor 1 (Tcf1) is the first T cell–specific protein induced by Notch signaling in the thymus, leading to the activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12675a50c74968cf01b24eb83d9993a
https://hdl.handle.net/1887/3182055
https://hdl.handle.net/1887/3182055
Autor:
Frank J. T. Staal, Erik B. van den Akker, Marcel J. T. Reinders, Marja E. Jakobs, Stavros Makrodimitris, Frank Baas, Henne Holstege, Quinten Waisfisz, P. Eline Slagboom, Martijn H. Brugman, Ted Bradley, Daphne de Jong, Tatjana Nikolic, Marc Hulsman
Publikováno v:
Leukemia
Leukemia, 35, 2125-2129. SPRINGERNATURE
van den Akker, E B, Makrodimitris, S, Hulsman, M, Brugman, M H, Nikolic, T, Bradley, T, Waisfisz, Q, Baas, F, Jakobs, M E, de Jong, D, Slagboom, P E, Staal, F J T, Reinders, M J T & Holstege, H 2021, ' Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian ', Leukemia, vol. 35, no. 7, pp. 2125-2129 . https://doi.org/10.1038/s41375-020-01086-0
Leukemia, 35(7), 2125-2129. Nature Publishing Group
Leukemia, 35 (2021)(7)
Leukemia, 35, 2125-2129. SPRINGERNATURE
van den Akker, E B, Makrodimitris, S, Hulsman, M, Brugman, M H, Nikolic, T, Bradley, T, Waisfisz, Q, Baas, F, Jakobs, M E, de Jong, D, Slagboom, P E, Staal, F J T, Reinders, M J T & Holstege, H 2021, ' Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian ', Leukemia, vol. 35, no. 7, pp. 2125-2129 . https://doi.org/10.1038/s41375-020-01086-0
Leukemia, 35(7), 2125-2129. Nature Publishing Group
Leukemia, 35 (2021)(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353fc505e74566f77a7d574d1921b161
https://pubmed.ncbi.nlm.nih.gov/33184493
https://pubmed.ncbi.nlm.nih.gov/33184493
Autor:
Erik B. van den Akker, Marcel J. T. Reinders, Martijn H. Brugman, P. Eline Slagboom, Marja E. Jakobs, Frank J. T. Staal, Frank Baas, Henne Holstege, Daphne de Jong, Tanja Nikolic, Stavros Makrodimitris, Ted Bradley, Marc Hulsman, Quinten Waisfisz
The aged hematopoietic system is characterized by decreased immuno-competence and by a reduced number of hematopoietic stem cells (HSCs) that actively generates new blood cell (age-related clonal hematopoiesis, ARCH). While both aspects are commonly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b8febdc6519b6cceb509b15d57203a5
https://doi.org/10.1101/788752
https://doi.org/10.1101/788752
Publikováno v:
Annals of the New York Academy of Sciences
In contrast to all other blood and immune cells, T lymphocytes do not develop in the bone marrow (BM), but in the specialized microenvironment provided by the thymus. Similar to the other lineages, however, all T cells arise from multipotent hematopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9df88229629104e953495c415c20def9
https://doi.org/10.1111/nyas.12995
https://doi.org/10.1111/nyas.12995
Autor:
Jeroen van Bergen, Yvonne Kooy-Winkelaar, Frederike Schmitz, M. Luisa Mearin, Frits Koning, George M.C. Janssen, Allan Thompson, Jon J. van Rood, Chris J. J. Mulder, Dagmar Bouwer, Martijn H. Brugman, Arnoud H. de Ru, Tom van Gils, Gerd Bouma, Peter A. van Veelen
Publikováno v:
Proceedings of the National Academy of Sciences, 114(6), E980-E989
Kooy-Winkelaar, Y M C, Bouwer, D, Janssen, G M C, Thompson, A, Brugman, M H, Schmitz, F, de Ru, A H, van Gils, T, Bouma, G, van Rood, J J, van Veelen, P A, Mearin, M L, Mulder, C J, Koning, F & van Bergen, J 2017, ' CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 6, pp. E980-E989 . https://doi.org/10.1073/pnas.1620036114
Proceedings of the National Academy of Sciences of the United States of America, 114(6), E980-E989. National Academy of Sciences
Kooy-Winkelaar, Y M C, Bouwer, D, Janssen, G M C, Thompson, A, Brugman, M H, Schmitz, F, de Ru, A H, van Gils, T, Bouma, G, van Rood, J J, van Veelen, P A, Mearin, M L, Mulder, C J, Koning, F & van Bergen, J 2017, ' CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 6, pp. E980-E989 . https://doi.org/10.1073/pnas.1620036114
Proceedings of the National Academy of Sciences of the United States of America, 114(6), E980-E989. National Academy of Sciences
Refractory celiac disease type II (RCDII) is a severe complication of celiac disease (CD) characterized by the presence of an enlarged clonal population of innate intraepithelial lymphocytes (IELs) lacking classical B-, T-, and natural killer (NK)-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d81ee822e973884869115ee2bdad4a2
https://doi.org/10.1073/pnas.1620036114
https://doi.org/10.1073/pnas.1620036114
Autor:
Martijn H. Brugman, Zhixiong Li, Christopher Baum, Johann Meyer, Brigitte Schlegelberger, Celina Schauerte, Johannes Zuber, Doris Steinemann, Adrian Schwarzer, Helmut Holtmann
Publikováno v:
Oncogene. 34:3593-3604
High activation of the PI3K-AKT-mTOR pathway is characteristic for T-cell acute lymphoblastic leukemia (T-ALL). The activity of the master regulator of this pathway, PTEN, is often impaired in T-ALL. However, experimental evidence suggests that input
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf1060d99f11d4dd633a1af8cb499b2
https://doi.org/10.1038/onc.2014.290
https://doi.org/10.1038/onc.2014.290