Výsledky vyhledávání - "Martijn G. S. Rutten"

Akademický článek

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

Autor: Martijn G. S. Rutten, Yu Lei, Joanne H. Hoogerland, Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore A. Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel E. Thomas, Justina C. Wolters, Hilda van den Bos, Gilles Mithieux, Fabienne Rajas, Adil Mardinoglu, Diana C. J. Spierings, Alain de Bruin, Bart van de Sluis, Maaike H. Oosterveer

Publikováno v: Cancer & Metabolism, Vol 11, Iss 1, Pp 1-11 (2023)

Abstract Background Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. Hepatic GSD Ia is

Externí odkaz: https://doaj.org/article/176971327ab64839a0921d89e984a866

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Akademický článek

Dynamic Methods for Childhood Hypoglycemia Phenotyping: A Narrative Review

Autor: Alessandro Rossi, Martijn G. S. Rutten, Theo H. van Dijk, Barbara M. Bakker, Dirk-Jan Reijngoud, Maaike H. Oosterveer, Terry G. J. Derks

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Hypoglycemia results from an imbalance between glucose entering the blood compartment and glucose demand, caused by a defect in the mechanisms regulating postprandial glucose homeostasis. Hypoglycemia represents one of the most common metabolic emerg

Externí odkaz: https://doaj.org/article/aa2748dec44245458a088fa145090a7d

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Akademický článek

Functional Validation of the Putative Oncogenic Activity of PLAU

Autor: Federica Sarno, Désirée Goubert, Emilie Logie, Martijn G. S. Rutten, Mihaly Koncz, Christophe Deben, Anita E. Niemarkt, Lucia Altucci, Pernette J. Verschure, Antal Kiss, Wim Vanden Berghe, Marianne G. Rots

Publikováno v: Biomedicines, Vol 11, Iss 1, p 102 (2022)

Plasminogen activator, urokinase (PLAU) is involved in cell migration, proliferation and tissue remodeling. PLAU upregulation is associated with an increase in aggressiveness, metastasis, and invasion of several cancer types, including breast cancer.

Externí odkaz: https://doaj.org/article/96a430b70388450ba692e106845876d2

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Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia

Autor: Bertien Dethmers-Ausema, Niels J. Kloosterhuis, Folkert Kuipers, Gilles Mithieux, Anouk M. La Rose, Martijn G S Rutten, Oliver Soehnlein, Joanne A Hoogerland, J Hendrik Nijland, Marit Westerterp, Fabienne Rajas, Maaike H. Oosterveer, Arthur Flohr Svendsen, Venetia Bazioti, Michaël V. Lukens, Martijn van Faassen, Anouk G. Groenen

Publikováno v: Molecular metabolism
Molecular metabolism, Elsevier, 2021, pp.101265. ⟨10.1016/j.molmet.2021.101265⟩
Molecular metabolism, 53:101265, 1-14. ELSEVIER SCIENCE BV
Molecular Metabolism, Vol 53, Iss, Pp 101265-(2021)
Molecular Metabolism

Objective Glycogen storage disease type 1a (GSD Ia) is a rare inherited metabolic disorder caused by mutations in the glucose-6-phosphatase (G6PC1) gene. When untreated, GSD Ia leads to severe fasting-induced hypoglycemia. Although current intensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fee94b82da6e1129feb4ffc5aac411
https://www.hal.inserm.fr/inserm-03257584/document

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Exploiting epigenetics for the treatment of inborn errors of metabolism

Autor: Martijn G S Rutten, Maaike H. Oosterveer, Marianne G. Rots

Publikováno v: Journal of Inherited Metabolic Disease

Gene therapy is currently considered as the optimal treatment for inborn errors of metabolism (IEMs), as it aims to permanently compensate for the primary genetic defect. However, emerging gene editing approaches such as CRISPR‐Cas9, in which the D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4449488d4f4891aba8864d2ff1940d
https://doi.org/10.1002/jimd.12093

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C/EBPβ-LIP dually activates glycolysis and the malate aspartate shuttle to maintain NADH/NAD+ homeostasis

Autor: Martijn G S Rutten, Mathilde J.C. Broekhuis, Tobias Ackermann, Gertrud Kortman, Mohamad A. Zaini, Cornelis F. Calkhoven, Götz Hartleben, Hidde R. Zuidhof

Oncogene-induced metabolic reprograming supports cell growth and proliferation. Yet, it also links cancer cell survival to certain metabolic pathways and nutrients. In order to synthesise amino acids and nucleotidesde novofor growth and proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4ac7c0b7e1785911f954090c697d490
https://doi.org/10.1101/2020.10.09.333104

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