Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Martijn Fenaux"'
Autor:
Dalong Zhu, Weimin Wang, Guoyu Tong, Guoqing Ma, Jianhua Ma, Jie Han, Xin Zhang, Yang Liu, Shenglian Gan, Hong Qin, Qing Zheng, Jing Ning, Zhiyi Zhu, Mengying Guo, Yue Bu, Yao Li, Catherine L. Jones, Martijn Fenaux, Mohammed K. Junaidi, Susan Xu, Hai Pan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Glucagon-like peptide-1 (GLP-1) analogs are important therapeutics for type 2 diabetes and obesity. Ecnoglutide (XW003) is a novel, long-acting GLP-1 analog. We conducted a Phase 2, randomized, double-blind, placebo-controlled study enrollin
Externí odkaz:
https://doaj.org/article/6fc9855574f143a59ad4763f2df3fad9
Autor:
Wanjun Guo, Zheng Xu, Haixia Zou, Feng Li, Yao Li, Jing Feng, Zhiyi Zhu, Qing Zheng, Rui Zhu, Bin Wang, Yan Li, Sujuan Hao, Hong Qin, Catherine L. Jones, Eric Adegbite, Libnir Telusca, Martijn Fenaux, Weidong Zhong, Mohammed K. Junaidi, Susan Xu, Hai Pan
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101762- (2023)
Objective: Glucagon-like peptide (GLP)-1 is an incretin hormone that acts after food intake to stimulate insulin production, enhance satiety, and promote weight loss. Here we describe the discovery and characterization of ecnoglutide (XW003), a novel
Externí odkaz:
https://doaj.org/article/f29d307547b64b63868bd5e2762295f9
Autor:
Sarah E Boyce, Neeraj Tirunagari, Anita Niedziela-Majka, Jason Perry, Melanie Wong, Elaine Kan, Leanna Lagpacan, Ona Barauskas, Magdeleine Hung, Martijn Fenaux, Todd Appleby, William J Watkins, Uli Schmitz, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84808 (2014)
Elucidation of the mechanism of action of the HCV NS5B polymerase thumb site II inhibitors has presented a challenge. Current opinion holds that these allosteric inhibitors stabilize the closed, inactive enzyme conformation, but how this inhibition i
Externí odkaz:
https://doaj.org/article/511db7137be1485baa683530d590daed
Publikováno v:
Journal of Hepatology. 77:S726
Autor:
Erin Quirk, Feng Jin, Pengfei Guo, Daria B. Crittenden, Yujin Wang, Christopher T. Jones, Martijn Fenaux, Michael Charlton, Kevin Klucher, Clarence Eng, Qiong Zhang, Diana Chung
Publikováno v:
Clinical pharmacology in drug developmentReferences. 10(10)
TERN-101 is a nonsteroidal farnesoid X-receptor agonist being developed for the treatment of nonalcoholic steatohepatitis (NASH). We assessed the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of TERN-101 capsule and tablet formulations in
Autor:
Martijn Fenaux, Andrea Leonardi, Sreehari Babu, Peck Gee Seah, Wei Liu, Pei Yong Shi, Rao P S Srinivasa, Suresh B. Lakshminarayana, Haoying Xu, Jin Zhang, Fumiaki Yokokawa, Cheah Chen Seh, Francesca Blasco, Nahdiyah Abdul Ghafar, Wai Ling Chan, Gang Wang, Ellie Growcott, Feng Gu, Weidong Zhong, Keshi Wang, Mei Ding, Ratna Karuna, Siew Pheng Lim, Yen Liang Chen
Publikováno v:
Antimicrob Agents Chemother
Monophosphate prodrug analogs of 2′-deoxy-2′-fluoro-2′-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue virus activities in cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd646098b1cf2a7e9cd9dd08f0a432
https://europepmc.org/articles/PMC7674056/
https://europepmc.org/articles/PMC7674056/
Autor:
Wei Liu, Sreehari Babu, Wai Ling Chan, Suresh B. Lakshminarayana, Ellena Growcott, Peck Gee Seah, Martijn Fenaux, Mei Ding, Nahdiyah Abdul Ghafar, Gang Wang, Ratna Karuna, Cheah Chen Seh, Haoying Xu, Feng Gu, Weidong Zhong, Pei Yong Shi, Keshi Wang, Andrea Leonardi, Francesca Blasco, Yen Liang Chen, Srinivasa P. S. Rao, Siew Pheng Lim, Fumiaki Yokokawa, Jin Zhang
Monophosphate prodrug analogs of 2’-deoxy-2’-fluoro-2’-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue activities in cellular assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d10b314ef2182303dfcf7c75456ce
Publikováno v:
Journal of medicinal chemistry. 63(10)
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH is a serious condition that can progress to cirrhosis, liver failure, and
Autor:
Todd Appleby, Martijn Fenaux, Thomas Butler, Mark Charles Whitcomb, Gregory Chin, Rick Lee, Gabriel Birkus, Aesop Cho, Michael O'neil Hanrahan Clarke, Thorsten A. Kirschberg, Darius Babusis, Vangelis Aktoudianakis, Lijun Zhang, Thomas E. Edwards, Eisuke Murakami, Jie Xu, Choung U. Kim, Daniel Byun, Neil H. Squires, Edward Doerffler, Willard Lew, Adrian S. Ray, Joy Y. Feng, Ona Barauskas, Sammy Metobo, Ting Wang, Huiling Yang, Yeojin Park, Mish Michael R, Neeraj Tirunagari, Hong Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1840-1847
A series of 2′-fluorinated C -nucleosides were prepared and tested for anti-HCV activity. Among them, the triphosphate of 2′-fluoro-2′- C -methyl adenosine C -nucleoside ( 15 ) was a potent and selective inhibitor of the NS5B polymerase and mai
Autor:
Christopher Jones, Pengfei Guo, Qiong Zhang, Yujin Wang, Martijn Fenaux, Diana Chung, Erin Quirk
Publikováno v:
Journal of Hepatology. 73:S442-S443