Iron deficiency is related to lower muscle mass in community‐dwelling individuals and impairs myoblast proliferation

Autor: Joanna Sophia J. Vinke, Alan R. Gorter, Michele F. Eisenga, Wendy A. Dam, Peter van derMeer, Jacob van denBorn, Stephan J.L. Bakker, Martijn F. Hoes, Martin H. deBorst

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 4, Pp 1865-1879 (2023)

Abstract Background Loss of muscle mass is linked with impaired quality of life and an increased risk of morbidity and premature mortality. Iron is essential for cellular processes such as energy metabolism, nucleotide synthesis and numerous enzymati

Externí odkaz: https://doaj.org/article/3a734625f0e141a88004f9db1de7d54b

Concise Review: The Current State of Human In Vitro Cardiac Disease Modeling: A Focus on Gene Editing and Tissue Engineering

Autor: Martijn F. Hoes, Nils Bomer, Peter van derMeer

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 1, Pp 66-74 (2019)

Abstract Until recently, in vivo and ex vivo experiments were the only means to determine factors and pathways involved in disease pathophysiology. After the generation of characterized human embryonic stem cell lines, human diseases could readily be

Externí odkaz: https://doaj.org/article/c0ad230709394d358b61732ab55dfa1c

Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues

Autor: Annet N. Linders, Itamar B. Dias, Ekaterina S. Ovchinnikova, Mathilde C.S.C. Vermeer, Martijn F. Hoes, George Markousis Mavrogenis, Frederik E. Deiman, Karla F. Arevalo Gomez, Jacqueline M. Bliley, Jamil Nehme, Aryan Vink, Jourik Gietema, Rudolf A. de Boer, Daan Westenbrink, Herman H.W. Sillje, Denise Hilfiker-Kleiner, Linda W. van Laake, Adam W. Feinberg, Marco Demaria, Nils Bomer, Peter van der Meer

Publikováno v: JACC: CardioOncology.

Background: Doxorubicin is an essential cancer treatment, but its usefulness is hampered by the occurrence of cardiotoxicity. Nevertheless, the pathophysiology underlying doxorubicin-induced cardiotoxicity and the respective molecular mechanisms are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e162f1748f0af6ffa7f0cf129342df
https://doi.org/10.1016/j.jaccao.2023.03.012

Multi-omics analyses identify molecular signatures with prognostic values in different heart failure aetiologies

Autor: Joseph Pierre Aboumsallem, Canxia Shi, Sanne De Wit, George Markousis-Mavrogenis, Valentina Bracun, Tim R. Eijgenraam, Martijn F. Hoes, Wouter C. Meijers, Elles M. Screever, Marloes E. Schouten, Adriaan A. Voors, Herman H.W. Silljé, Rudolf A. De Boer

Publikováno v: Journal of Molecular and Cellular Cardiology, 175, 13-28. Academic Press
Journal of molecular and cellular cardiology, 175, 13-28. ELSEVIER SCI LTD

Background: Heart failure (HF) is the leading cause of morbidity and mortality worldwide, and there is an urgent need for more global studies and data mining approaches to uncover its underlying mechanisms. Multiple omics techniques provide a more ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348fe7553e8bb75d69fd2fa78806c757
https://pubmed.ncbi.nlm.nih.gov/36493852

In peripartum cardiomyopathy plasminogen activator inhibitor-1 is a potential new biomarker with controversial roles

Autor: Ofer Binah, Thomas Thum, Elisabeth Stelling, Tobias J. Pfeffer, Martijn F Hoes, Johann Bauersachs, Arash Haghikia, Melanie Ricke-Hoch, Michaela Scherr, Christine S. Falk, Zolt Arany, Britta Stapel, Nils Bomer, Denise Hilfiker-Kleiner, Peter van der Meer, Yulia Kiyan, Justus Nonhoff, Susanna Haidari, Stella Schlothauer

Publikováno v: Cardiovascular Research, 116(11), 1875-1886. Oxford University Press

Aims Peripartum cardiomyopathy (PPCM) is a life-threatening heart disease occurring in previously heart-healthy women. A common pathomechanism in PPCM involves the angiostatic 16 kDa-prolactin (16 kDa-PRL) fragment, which via NF-κB-mediated up-regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8c950c7bba60ad4fd22598dfff484f
https://doi.org/10.1093/cvr/cvz300