Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Martijn D P, Risseeuw"'
Autor:
Yanlin Jian, Martijn D. P. Risseeuw, Mathy Froeyen, Lijun Song, Davie Cappoen, Paul Cos, Hélène Munier-Lehmann, Serge van Calenbergh
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1730-1739 (2019)
A series of readily accessible 1-(piperidin-3-yl)thymine amides was designed, synthesised and evaluated as Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors. In line with the modelling results, most inhibitors showed reasonable MtbTMPK inhibitory
Externí odkaz:
https://doaj.org/article/60a10e54b7c64ecbbe4411d5e94387b7
Autor:
Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we presen
Externí odkaz:
https://doaj.org/article/b6242e5fce344e1e9535e44bda9ee7ff
Autor:
Yanlin Jian, Fabian Hulpia, Martijn D. P. Risseeuw, He Eun Forbes, Guy Caljon, Hélène Munier-Lehmann, Helena I. M. Boshoff, Serge Van Calenbergh
Publikováno v:
Molecules, Vol 25, Iss 12, p 2805 (2020)
A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modif
Externí odkaz:
https://doaj.org/article/9335a1cb31644688b92dd36518d8dfcd
Autor:
Michaël Canfyn, Martijn D. P. Risseeuw, Peter Blanckaert, Bart Desmedt, Eric Deconinck, Margot Balcaen, Serge Van Calenbergh, Celine Vanhee
Publikováno v:
DRUG TESTING AND ANALYSIS
This paper reports on the identification and full chemical characterization of the substance colloquially called "etonitazepyne" or "N-pyrrolidino etonitazene" (2-(4-ethoxybenzyl)-5-nitro-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazole), a potent N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349a9f6f974870d3bc3116c6f04c8a93
https://doi.org/10.1002/dta.3113
https://doi.org/10.1002/dta.3113
Autor:
Lijun Song, Martijn D. P. Risseeuw, Izet Karalic, Matthew O. Barrett, Kyle A. Brown, T. Kendall Harden, Serge Van Calenbergh
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4313-4325 (2014)
In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties wit
Externí odkaz:
https://doaj.org/article/90bc235eefcf4629b2b6b8d027b90751
Autor:
Serge Van Calenbergh, Fabian Hulpia, Helena I. Boshoff, Martijn D. P. Risseeuw, He Eun Forbes, Guy Caljon, Yanlin Jian, Hélène Munier-Lehmann
Publikováno v:
Journal of medicinal chemistry
Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and further optimization led to the identification of the potent antitubercular 2-thio-sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c7c7f323754a0570c590fd5ef79aa2
https://doi.org/10.1021/acs.jmedchem.0c01374
https://doi.org/10.1021/acs.jmedchem.0c01374
Autor:
Evelien Carrette, Kristl Vonck, Erine Craey, Wytse Wadman, Martijn D. P. Risseeuw, Jeroen Spanoghe, Robrecht Raedt, Jean Delbeke, Serge Van Calenbergh, Lars Emil Larsen, Paul Boon
Publikováno v:
Proceedings of the Neural Interfaces and Artificial Senses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6f31d114998fdcc6c80f67d79cd487b
https://doi.org/10.29363/nanoge.nias.2021.024
https://doi.org/10.29363/nanoge.nias.2021.024
Autor:
Barbara De Moerloose, Serge Van Calenbergh, Wojciech Ornatowski, Steven Goossens, Sofie Peirs, Alexandre Chigaev, Wouter Van Loocke, Charles G. Mullighan, Pieter Van Vlierberghe, Christian K. Nickl, Takeshi Takarada, Mignon L. Loh, Eliseo F. Castillo, Laurence C. Cheung, Dominique Perez, Béatrice Lintermans, Yukio Yoneda, Frederik W. van Delft, Richard B. Lock, Stuart S. Winter, Juliette Roels, Stephen P. Hunger, Lisa Demoen, Lindy Reunes, Ksenia Matlawska-Wasowska, Larry A. Sklar, Monique Nysus, Rishi S. Kotecha, Tim Lammens, Huining Kang, Dieter Deforce, Tim Pieters, Nitesh D. Sharma, Filip Van Nieuwerburgh, Martijn D. P. Risseeuw, Seth D. Merkley, Filip Matthijssens
Publikováno v:
J Clin Invest
JOURNAL OF CLINICAL INVESTIGATION
JOURNAL OF CLINICAL INVESTIGATION
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7320b73d3d90f1b61255b31a6ace270f
https://europepmc.org/articles/PMC7954605/
https://europepmc.org/articles/PMC7954605/
Autor:
Yanlin, Jian, He Eun, Forbes, Fabian, Hulpia, Martijn D P, Risseeuw, Guy, Caljon, Hélène, Munier-Lehmann, Helena I M, Boshoff, Serge, Van Calenbergh
Publikováno v:
Journal of medicinal chemistry. 64(1)
Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b482c092759f0cd1d80e44d18a413aa0
https://pubmed.ncbi.nlm.nih.gov/33347317
https://pubmed.ncbi.nlm.nih.gov/33347317
Autor:
Mingcheng, Qian, Adrián, Ricarte, Elise, Wouters, James A R, Dalton, Martijn D P, Risseeuw, Jesús, Giraldo, Serge, Van Calenbergh
Publikováno v:
European journal of medicinal chemistry. 212
Employing two different alkyne-modified dopamine agonists to construct bivalent compounds via click chemistry resulted in the identification of a bivalent ligand (11c) for dopamine D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5402be15cdd85f5508d97baddf3f19b
https://pubmed.ncbi.nlm.nih.gov/33450620
https://pubmed.ncbi.nlm.nih.gov/33450620