Výsledky vyhledávání - "Martijn Akse"

Abstract 740: A robust rapid mRNA based test to profile simultaneously ER, AR, PI3K and MAPK functional signaling pathway activity for precision oncology

Autor: Hannah Park, Diederick Keizer, Martijn van Zelst, Eveline den Biezen, Dianne Arnoldina Margaretha Wilhelmina Van Strijp, Saskia Vermeer, Anthony Magliocco, Martijn Akse

Publikováno v: Cancer Research. 81:740-740

Introduction: OncoSignal test was developed to determine and quantify functional signal transduction pathway activity levels of 4 key oncogenic signaling pathways (ER, AR, PI3K and MAPK), based on the quantitative measurement of mRNA expression level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06830db829e2eca2a77fab24e71b9692
https://doi.org/10.1158/1538-7445.am2021-740

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Development of a qPCR based ER signaling pathway activity test predictive for response to endocrine therapy in ER IHC positive breast cancer patients

Autor: Yvonne Wesseling-Rozendaal, Martijn Akse, Márcia Alves De Inda, A. van Brussel, H. van Ooijen, E. den Biezen-Timmermans, Wim Verhaegh, H. van Zon, Anke Pierik

Publikováno v: European Journal of Cancer. 138:S88-S89

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0276b538bfb8071d836250b0257d536f
https://doi.org/10.1016/s0959-8049(20)30772-3

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1208P EIT PACMAN study results: OncoSignal signaling pathway analysis using FFPE-compatible tests identifies actionable cancer targets in a variety of cancers without actionable mutations

Autor: Fabien Calvo, Patricia Martin-Romano, D. van Strijp, E. den Biezen-Timmermans, Maud Ngo-Camus, A. van de Stolpe, Claudio Nicotra, S. Vermeer-van de Laar, Martijn Akse, Sigi Neerken, Antoine Italiano

Publikováno v: Annals of Oncology. 31:S791

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8996e3c52ad46e50a7808c44ebb4e54
https://doi.org/10.1016/j.annonc.2020.08.102

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Abstract 1331: First results of the EIT PACMAN Study: OncoSignal pathway analysis to identify clinically actionable signal transduction pathway activity in a variety of cancer types

Autor: Alexander M.M. Eggermont, Fabien Calvo, Claudio Nicotra, Sieglinde Neerken, Martijn Akse, Christophe Massard, Eveline Den Biezen-Timmerman, Maud Ngo, Paul van de Wiel, Anja van de Stolpe, Patricia Martin-Romano

Publikováno v: Cancer Research. 80:1331-1331

Introduction: Precision medicine has shown to improve outcomes of cancer patients by identifying oncogenic alterations and actionable mutations. Yet, most tests perform DNA sequencing and are not able to discriminate which tumor driving signaling pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30f06415f69d2aeca3b089b0a0094f99
https://doi.org/10.1158/1538-7445.am2020-1331

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Abstract 4261: Development of quantitative multi-platform tests for easy readout of AR, ER, PI3K and MAPK pathway activity to unravel pathophysiology across cancer and tissue types

Autor: Wim Verhaegh, Martijn Akse, Laurent Holtzer, Anne van Brussel, Eveline den Biezen-Timmermans, Yvonne Wesseling-Rozendaal, Márcia Alves De Inda, Henk van Ooijen, Sandra M. van den Bosch, Anke Pierik, Hans Van Zon

Publikováno v: Cancer Research. 80:4261-4261

Introduction: Currently, the selection of targeted therapy is commonly based on genetic data, such as well-known gene mutations, but these mutations do not provide conclusive evidence for the functional activation of the affected pathway. For this re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c0ebca44b08d23b8677e79463b02f14
https://doi.org/10.1158/1538-7445.am2020-4261

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Analysis of signaling pathway activity in desmoid-type fibromatosis (DF) to identify druggable pathways

Autor: Martijn Akse, Eveline den Biezen-Timmermans, Jean-Yves Blay, Anja van de Stolpe, Nicolas Penel

Publikováno v: Journal of Clinical Oncology. 38:e23558-e23558

e23558 Background: DF are locally invasive soft tissue tumors of fibroblast origin, with unpredictable course. CTTNB1 mutations are a hallmark of DF. Molecular-targeted therapies are lacking. Recently developed OncoSignal (www.philips.com/oncosignal)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e49b29a9da890e440c7280c5b3b7150d
https://doi.org/10.1200/jco.2020.38.15_suppl.e23558

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EIT PACMAN Study preliminary results: OncoSignal pathway analysis identifies actionable cancer targets

Autor: Patricia Martin, Maud Ngo-Camus, Claudio Nicotra, Fabien Calvo, Alexander M.M. Eggermont, Martijn Akse, Christophe Massard, Eveline den Biezen-Timmermans, Sigi Neerken, Anja van de Stolpe, Paul van de Wiel

Publikováno v: Journal of Clinical Oncology. 38:e15606-e15606

e15606 Background: Precision medicine refers to tailoring of treatment to each individual patient, although identifying tumor driving signaling pathways (SP) that are functionally active is still a challenge. OncoSignal pathway tests quantitatively m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5068445d8e9f18b6cf8c9b4b9694c726
https://doi.org/10.1200/jco.2020.38.15_suppl.e15606

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Changes in ER pathway activity score during neoadjuvant letrozole to assess therapy response and predict disease free survival (DFS) in ER positive breast cancer patients

Autor: Anu Fernando, A. van de Stolpe, Márcia Alves De Inda, Diederick Keizer, J.M. Dixon, Arran K Turnbull, Martijn Akse, Carlos Martinez-Perez, Andrew H. Sims, H. van Zon, Danielle Elisa Willemine Clout

Publikováno v: Annals of Oncology. 30:v95

Background Despite ER positive IHC staining, some patients do not respond to neoadjuvant endocrine therapy, suggesting that ER staining lacks specificity to predict response. We developed a method to infer a quantitative signal transduction pathway a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32646b8c3afb7e37bb6bc0bfa55f1d3b
https://doi.org/10.1093/annonc/mdz240.107

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