Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Martijn A Huynen"'
Autor:
Lisette Meerstein-Kessel, Jeron Venhuizen, Daniel Garza, Nicholas I Proellochs, Emma J Vos, Joshua M Obiero, Philip L Felgner, Robert W Sauerwein, Marynthe Peters, Annie S P Yang, Martijn A Huynen
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 4, p e1008067 (2021)
Plasmodium species, the causative agent of malaria, have a complex life cycle involving two hosts. The sporozoite life stage is characterized by an extended phase in the mosquito salivary glands followed by free movement and rapid invasion of hepatoc
Externí odkaz:
https://doaj.org/article/7f61cd401c11454e932233d79b98bc50
Autor:
Teunis J P van Dam, Julie Kennedy, Robin van der Lee, Erik de Vrieze, Kirsten A Wunderlich, Suzanne Rix, Gerard W Dougherty, Nils J Lambacher, Chunmei Li, Victor L Jensen, Michel R Leroux, Rim Hjeij, Nicola Horn, Yves Texier, Yasmin Wissinger, Jeroen van Reeuwijk, Gabrielle Wheway, Barbara Knapp, Jan F Scheel, Brunella Franco, Dorus A Mans, Erwin van Wijk, François Képès, Gisela G Slaats, Grischa Toedt, Hannie Kremer, Heymut Omran, Katarzyna Szymanska, Konstantinos Koutroumpas, Marius Ueffing, Thanh-Minh T Nguyen, Stef J F Letteboer, Machteld M Oud, Sylvia E C van Beersum, Miriam Schmidts, Philip L Beales, Qianhao Lu, Rachel H Giles, Radek Szklarczyk, Robert B Russell, Toby J Gibson, Colin A Johnson, Oliver E Blacque, Uwe Wolfrum, Karsten Boldt, Ronald Roepman, Victor Hernandez-Hernandez, Martijn A Huynen
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216705 (2019)
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies. The current rate at which new ciliopathy genes are identified suggests that many ciliar
Externí odkaz:
https://doaj.org/article/206fb09f592a41a7979de76d71996765
Autor:
Mariano A. Molina, William P. J. Leenders, Martijn A. Huynen, Willem J. G. Melchers, Karolina M. Andralojc
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Persistent infections with high-risk human papillomavirus (hrHPV) can cause cervical squamous intraepithelial lesions (SIL) that may progress to cancer. The cervicovaginal microbiome (CVM) correlates with SIL, but the temporal com
Externí odkaz:
https://doaj.org/article/38089f5a8b1b4bd9bf3821bd54f9488a
Autor:
Robin van der Lee, Qian Feng, Martijn A Langereis, Rob Ter Horst, Radek Szklarczyk, Mihai G Netea, Arno C Andeweg, Frank J M van Kuppeveld, Martijn A Huynen
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004553 (2015)
The RIG-I-like receptor (RLR) pathway is essential for detecting cytosolic viral RNA to trigger the production of type I interferons (IFNα/β) that initiate an innate antiviral response. Through systematic assessment of a wide variety of genomics da
Externí odkaz:
https://doaj.org/article/83c13d2a5fe64fe289f11af4c47b32e9
Autor:
Joshua Gillard, Madeleine Suffiotti, Peter Brazda, Prashanna B. Venkatasubramanian, Pauline Versteegen, Marien I. de Jonge, Dominic Kelly, Sagida Bibi, Marta Valente Pinto, Elles Simonetti, Mihaela Babiceanu, Andrew Kettring, Cristina Teodosio, Ronald de Groot, Guy Berbers, Hendrik G. Stunnenberg, Brian Schanen, Craig Fenwick, Martijn A. Huynen, Dimitri A. Diavatopoulos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Many countries continue to experience pertussis epidemics despite widespread vaccination. Waning protection after booster vaccination has highlighted the need for a better understanding of the immunological factors that promote durable prote
Externí odkaz:
https://doaj.org/article/070c1fead68940ffb909a241214acbe3
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125795 (2015)
Synthetic Lethal (SL) genetic interactions play a key role in various types of biological research, ranging from understanding genotype-phenotype relationships to identifying drug-targets against cancer. Despite recent advances in empirical measuring
Externí odkaz:
https://doaj.org/article/fbb33e0e87a44d5599693f7957cee3de
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139665 (2015)
Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction stoichiometry combined with flux capacity constraints determine the space of allowable reaction rates. This space is often large and a central challenge in metabol
Externí odkaz:
https://doaj.org/article/c56482c8745e4f95944ed8831ccfd094
Autor:
Merel A W Oortveld, Shivakumar Keerthikumar, Martin Oti, Bonnie Nijhof, Ana Clara Fernandes, Korinna Kochinke, Anna Castells-Nobau, Eva van Engelen, Thijs Ellenkamp, Lilian Eshuis, Anne Galy, Hans van Bokhoven, Bianca Habermann, Han G Brunner, Christiane Zweier, Patrik Verstreken, Martijn A Huynen, Annette Schenck
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003911 (2013)
Intellectual Disability (ID) disorders, defined by an IQ below 70, are genetically and phenotypically highly heterogeneous. Identification of common molecular pathways underlying these disorders is crucial for understanding the molecular basis of cog
Externí odkaz:
https://doaj.org/article/ff42952b92fc4a049448b26baa6ad4b0
Autor:
Elena J Tucker, Bas F J Wanschers, Radek Szklarczyk, Hayley S Mountford, Xiaonan W Wijeyeratne, Mariël A M van den Brand, Anne M Leenders, Richard J Rodenburg, Boris Reljić, Alison G Compton, Ann E Frazier, Damien L Bruno, John Christodoulou, Hitoshi Endo, Michael T Ryan, Leo G Nijtmans, Martijn A Huynen, David R Thorburn
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004034 (2013)
Mitochondrial oxidative phosphorylation (OXPHOS) is responsible for generating the majority of cellular ATP. Complex III (ubiquinol-cytochrome c oxidoreductase) is the third of five OXPHOS complexes. Complex III assembly relies on the coordinated exp
Externí odkaz:
https://doaj.org/article/93999b89de8d43acbcc2fe2d63f732d2
Autor:
Michiel Vos, Tim A H te Beek, Marc A van Driel, Martijn A Huynen, Adam Eyre-Walker, Mark W J van Passel
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62447 (2013)
Quantifying patterns of adaptive divergence between taxa is a major goal in the comparative and evolutionary study of prokaryote genomes. When applied appropriately, the McDonald-Kreitman (MK) test is a powerful test of selection based on the relativ
Externí odkaz:
https://doaj.org/article/c21dd23906c44252baed88af2bec3f75