Age-Related Variation in Sympathetic Nerve Distribution in the Human Spleen

Autor: Cindy G. J. Cleypool, David J. Brinkman, Claire Mackaaij, Peter G. J. Nikkels, Martijn A. Nolte, Misha D. Luyer, Wouter J. de Jonge, Ronald L. A. W. Bleys

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Introduction: The cholinergic anti-inflammatory pathway (CAIP) has been proposed as an efferent neural pathway dampening the systemic inflammatory response via the spleen. The CAIP activates the splenic neural plexus and a subsequent series of intras

Externí odkaz: https://doaj.org/article/6d80e23424b04107942aecc892ab75c0

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

Autor: Corina A. Ghebes, Jess Morhayim, Marion Kleijer, Merve Koroglu, Stefan J. Erkeland, Remco Hoogenboezem, Eric Bindels, Floris P. J. van Alphen, Maartje van den Biggelaar, Martijn A. Nolte, Bram C. J. van der Eerden, Eric Braakman, Carlijn Voermans, Jeroen van de Peppel

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)

Recently, we and others have illustrated that extracellular vesicles (EVs) have the potential to support hematopoietic stem and progenitor cell (HSPC) expansion; however, the mechanism and processes responsible for the intercellular communication by

Externí odkaz: https://doaj.org/article/f63912cbb2284cb18223a36ce8f0da38

Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium

Autor: Timo Rademakers, Marieke Goedhart, Mark Hoogenboezem, Alexander García Ponce, Jos van Rijssel, Maryna Samus, Michael Schnoor, Stefan Butz, Stephan Huveneers, Dietmar Vestweber, Martijn A. Nolte, Carlijn Voermans, Jaap D. van Buul

Publikováno v: Haematologica, Vol 105, Iss 12 (2020)

Bone marrow endothelium plays an important role in the homing of hematopoietic stem and progenitor cells upon transplantation, but surprisingly little is known on how the bone marrow endothelial cells regulate local permeability and hematopoietic ste

Externí odkaz: https://doaj.org/article/1d4bdbd49d9148a4be4889ee5c472fdd

The Bone Marrow as Sanctuary for Plasma Cells and Memory T-Cells: Implications for Adaptive Immunity and Vaccinology

Autor: Stefan A. Slamanig, Martijn A. Nolte

Publikováno v: Cells, Vol 10, Iss 6, p 1508 (2021)

The bone marrow (BM) is key to protective immunological memory because it harbors a major fraction of the body’s plasma cells, memory CD4+ and memory CD8+ T-cells. Despite its paramount significance for the human immune system, many aspects of how

Externí odkaz: https://doaj.org/article/6dcbd2fd40fe480cbc3f876c7b5fdb12

Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1

Autor: Max L B Grönloh, Janine J G Arts, Sebastián Palacios Martínez, Amerens A van der Veen, Lanette Kempers, Abraham C I van Steen, Joris J T H Roelofs, Martijn A Nolte, Joachim Goedhart, Jaap D van Buul

Publikováno v: Grönloh, M L B, Arts, J J G, Palacios Martínez, S, van der Veen, A A, Kempers, L, van Steen, A C I, Roelofs, J J T H, Nolte, M A, Goedhart, J & van Buul, J D 2023, ' Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1 ', EMBO Reports, vol. 24, no. 1, e55483 . https://doi.org/10.15252/embr.202255483
EMBO reports, 24(1):e55483. Wiley-Blackwell
EMBO Reports, 24(1):e55483. Wiley-Blackwell

Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration ‘hotspot’ regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e948a7eee2654f8daa2c0cb6818aa
https://research.vumc.nl/en/publications/977802a3-56bf-40d5-8031-092edf437de6