Výsledky vyhledávání - "Martijn, Schenning"

Akademický článek

Phosphatidylinositol transfer protein α regulates growth and apoptosis of NIH3T3 cells

Autor: Martijn Schenning, Claudia M. van Tiel, Daniëlle van Manen, Jord C. Stam, Barend M. Gadella, Karel W.A. Wirtz, Gerry T. Snoek

Publikováno v: Journal of Lipid Research, Vol 45, Iss 8, Pp 1555-1564 (2004)

Mouse fibroblast cells overexpressing phosphatidylinositol transfer protein α [PI-TPα; sense PI-TPα (SPIα) cells] show a significantly increased rate of proliferation and an extreme resistance toward ultraviolet- or tumor necrosis factor-α-induc

Externí odkaz: https://doaj.org/article/7b6a912c48804825be7ccd62a72321a4

Zobrazit plný text záznamu

Fast, selective and quantitative protein profiling of adenovirus-vector based vaccines by ultra-performance liquid chromatography

Autor: Ewoud van Tricht, Cari Sänger van de Griend, Pascal de Raadt, Marta Germano, Harold Backus, Annemiek Verwilligen, Martijn Schenning, Govert W. Somsen

Publikováno v: Journal of Chromatography A, 1581-1582, 25-32. Elsevier
Journal of Chromatography. a
van Tricht, E, de Raadt, P, Verwilligen, A, Schenning, M, Backus, H, Germano, M, Somsen, G W & Sänger-van de Griend, C E 2018, ' Fast, selective and quantitative protein profiling of adenovirus-vector based vaccines by ultra-performance liquid chromatography ', Journal of Chromatography A, vol. 1581-1582, pp. 25-32 . https://doi.org/10.1016/j.chroma.2018.10.045

Highlights • A validated method for quantitative protein profiling in adenovirus-based vaccines. • 14 Adenovirus proteins baseline separated within 17 min by RP-UPLC. • Adenovirus-based samples directly injected, needing no sample pretreatment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752714c2c85777476c295b68ce2076ab
https://doi.org/10.1016/j.chroma.2018.10.045

Zobrazit plný text záznamu

Implementation of at‐line capillary zone electrophoresis for fast and reliable determination of adenovirus concentrations in vaccine manufacturing

Autor: Francisca Galindo Garre, Cari Sänger van de Griend, Harold Backus, Govert W. Somsen, Marta Germano, Lars Geurink, Martijn Schenning, Ewoud van Tricht

Publikováno v: Electrophoresis, 40(18-19), 2277-2284. Wiley-VCH Verlag
van Tricht, E, Geurink, L, Galindo Garre, F, Schenning, M, Backus, H, Germano, M, Somsen, G W & Sänger – van de Griend, C E 2019, ' Implementation of at-line capillary zone electrophoresis for fast and reliable determination of adenovirus concentrations in vaccine manufacturing ', Electrophoresis, vol. 40, no. 18-19, pp. 2277-2284 . https://doi.org/10.1002/elps.201900068

A CZE method was validated and implemented for fast and accurate in-process determination of adenovirus concentrations of downstream process samples obtained during manufacturing of adenovirus vector-based vaccines. An analytical-quality-by-design ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88798272a058ff4a0b8adac12ca2d3bd
https://doi.org/10.1002/elps.201900068

Zobrazit plný text záznamu

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases

Autor: Nick R. Leslie, Ian H. Batty, Alexander Gray, Miles J. Dixon, Martijn Schenning

Publikováno v: Advances in Biological Regulation. 52:205-213

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc524fc1688deea3ccbbb9bfb571b90c
https://doi.org/10.1016/j.advenzreg.2011.09.010

Zobrazit plný text záznamu

A phosphatidylinositol transfer protein α-dependent survival factor protects cultured primary neurons against serum deprivation-induced cell death

Autor: Freek L. van Muiswinkel, Gerry T. Snoek, Dop P. R. Bär, Peter Sodaar, Hanneke Bunte, Karel W. A. Wirtz, Martijn Schenning

Publikováno v: Journal of Neurochemistry. 97:707-715

Selective neuronal loss is a prominent feature in both acute and chronic neurological disorders. Recently, a link between neurodegeneration and a deficiency in the lipid transport protein phosphatidylinositol transfer protein α (PI-TPα) has been de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7bc038390085e945371cf994781b7da
https://doi.org/10.1111/j.1471-4159.2006.03729.x

Zobrazit plný text záznamu

Overexpression of phosphatidylinositol transfer protein β in NIH3T3 cells has a stimulatory effect on sphingomyelin synthesis and apoptosis

Autor: Martijn Schenning, Claudia M. van Tiel, Gerry T. Snoek, Karel W. A. Wirtz

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1636:151-158

Phosphatidylinositol transfer proteins (PI-TPs) consist of two isoforms (PI-TPalpha and PI-TPbeta), which differ in phospholipid transfer properties and intracellular localization. Both PI-TP isoforms are substrates for protein kinase C and contain a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4177e02405079884e79ead410748059d
https://doi.org/10.1016/j.bbalip.2003.08.009

Zobrazit plný text záznamu

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold

Autor: Martijn Schenning, Daan M. F. van Aalten, Nick R. Leslie, Ian H. Batty, Miles J. Dixon, C. Peter Downes, Lyudmila Nedyalkova, Yufeng Tong, Mark Agacan, Alexander Gray, Hee-Won Park, Wolfram Tempel

Publikováno v: The Journal of Biological Chemistry

Background: Phosphoinositide 3-kinase lipid signals exert important biological effects through proteins with specific recognition domains. Results: We identify a novel such protein domain in IQGAP proteins and define its crystal structure and phospho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a773bdeff0d5276bbd1e4a1d325a038
https://pubmed.ncbi.nlm.nih.gov/22493426

Zobrazit plný text záznamu

The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway

Autor: Gerry T. Snoek, Martijn Schenning, Diana Avram, Karel W. A. Wirtz, Joachim Goedhart, Theodorus W. J. Gadella

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research, 1783(10), 1700-1706. Elsevier

The conditioned medium (CM) from mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein alpha (PI-TPalpha; SPIalpha cells) demonstrates an increased anti-apoptotic activity compared with CM from wild type NIH3T3 (wtNIH3T3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7efe98c3443d83176a8617d2896925
https://pubmed.ncbi.nlm.nih.gov/18501717

Zobrazit plný text záznamu

The anti-apoptotic MAP kinase pathway is inhibited in NIH3T3 fibroblasts with increased expression of phosphatidylinositol transfer protein beta

Autor: Claudia M. van Tiel, Karel W. A. Wirtz, Martijn Schenning, Gerry T. Snoek

Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1773(11), 1664-1671. Elsevier

Mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein beta (PI-TPbeta, SPIbeta cells) demonstrate a low rate of proliferation and a high sensitivity towards UV-induced apoptosis when compared with wtNIH3T3 cells. In contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa19ac98eda58ae78c08ea232a64853
https://pubmed.ncbi.nlm.nih.gov/17683809

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání