Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Martijn, Koehorst"'
Autor:
Mara P.H. van Trijp, Melany Rios-Morales, Ben Witteman, Fentaw Abegaz, Albert Gerding, Ran An, Martijn Koehorst, Bernard Evers, Katja C.V. van Dongen, Erwin G. Zoetendal, Henk Schols, Lydia A. Afman, Dirk-Jan Reijngoud, Barbara M. Bakker, Guido J. Hooiveld
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109208- (2024)
Summary: Consumption of fructo- (FOS) and galacto-oligosaccharides (GOS) has health benefits which have been linked in part to short-chain fatty acids (SCFA) production by the gut microbiota. However, detailed knowledge of this process in the human i
Externí odkaz:
https://doaj.org/article/cd41ade7fb8e4d98876000536f453c8e
Autor:
Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Esther Verkade, Melany K. Veentjer, Theo H. van Dijk, Vincent W. Bloks, Rick Havinga, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2495 (2023)
Bile acids (BAs) and their signaling pathways have been identified as therapeutic targets for liver and metabolic diseases. We generated Cyp2c70−/− (KO) mice that were not able to convert chenodeoxycholic acid into rodent-specific muricholic acid
Externí odkaz:
https://doaj.org/article/6f2bbd3a48534fe2b250f2e7649963fb
Autor:
Melany Rios-Morales, Mara P. H. van Trijp, Christiane Rösch, Ran An, Theo Boer, Albert Gerding, Naomi de Ruiter, Martijn Koehorst, M. Rebecca Heiner-Fokkema, Henk A. Schols, Dirk-Jan Reijngoud, Guido J. E. J. Hooiveld, Barbara M. Bakker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Detailed knowledge on the fate of dietary components inside the human intestinal tract is lacking. Access to this inner world of digestion is now possible through novel human gastrointestinal sampling capsules. Due to the novelty of such dev
Externí odkaz:
https://doaj.org/article/06a21ae74d734b99a00a021edd180d58
Autor:
Jan Freark de Boer, Hilde D. de Vries, Anna Palmiotti, Rumei Li, Marwah Doestzada, Joanne A. Hoogerland, Jingyuan Fu, Anouk M. La Rose, Marit Westerterp, Niels L. Mulder, Milaine V. Hovingh, Martijn Koehorst, Niels J. Kloosterhuis, Justina C. Wolters, Vincent W. Bloks, Joel T. Haas, David Dombrowicz, Bart Staels, Bart van de Sluis, Folkert Kuipers
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1045-1069 (2021)
Background and Aims: Bile acids (BAs) aid intestinal fat absorption and exert systemic actions by receptor-mediated signaling. BA receptors have been identified as drug targets for liver diseases. Yet, differences in BA metabolism between humans and
Externí odkaz:
https://doaj.org/article/7532521445514e72b3e86eded4106a3d
Autor:
Kimber van Vliet, Wiggert G. van Ginkel, Esther van Dam, Pim de Blaauw, Martijn Koehorst, Hermi A. Kingma, Francjan J. van Spronsen, M. Rebecca Heiner-Fokkema
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-8 (2020)
Abstract Background This study investigated the agreement between various dried blood spot (DBS) and venous blood sample measurements of phenylalanine and tyrosine concentrations in Phenylketonuria (PKU) and Tyrosinemia type 1 (TT1) patients. Study d
Externí odkaz:
https://doaj.org/article/89213eef49374052ac8036acb04552e2
Autor:
Jan Freark de Boer, Esther Verkade, Niels L. Mulder, Hilde D. de Vries, Nicolette Huijkman, Martijn Koehorst, Theo Boer, Justina C. Wolters, Vincent W. Bloks, Bart van de Sluis, Folkert Kuipers
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 291-305 (2020)
Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5. These receptors are targets for therapy in cholestati
Externí odkaz:
https://doaj.org/article/1b56e3171b514bbe9f8130fcfd347f64
Autor:
Andries Heida, Nanda Gruben, Leen Catrysse, Martijn Koehorst, Mirjam Koster, Niels J. Kloosterhuis, Albert Gerding, Rick Havinga, Vincent W. Bloks, Laura Bongiovanni, Justina C. Wolters, Theo van Dijk, Geert van Loo, Alain de Bruin, Folkert Kuipers, Debby P.Y. Koonen, Bart van de Sluis
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101349- (2021)
Objective: Obesity-related chronic inflammation plays an important role in the development of Metabolic Associated Fatty Liver Disease (MAFLD). Although the contribution of the pro-inflammatory NF-κB signaling pathway to the progression from simple
Externí odkaz:
https://doaj.org/article/54c1ebb08d38492b9a76c2c3c92de6e6
Autor:
Rumei Li, Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Yue Zhang, Kim Kats, Vincent W. Bloks, Jingyuan Fu, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100134- (2021)
Bile acids (BAs) play important roles in lipid homeostasis, and BA signaling pathways serve as therapeutic targets for nonalcoholic fatty liver disease (NAFLD). Recently, we generated cytochrome P450, family 2, subfamily C, polypeptide 70 (Cyp2c70−
Externí odkaz:
https://doaj.org/article/f8cb60c473764338b6419affd52446ef
Autor:
Lianmin Chen, Inge C.L. van den Munckhof, Kiki Schraa, Rob ter Horst, Martijn Koehorst, Martijn van Faassen, Claude van der Ley, Marwah Doestzada, Daria V. Zhernakova, Alexander Kurilshikov, Vincent W. Bloks, Albert K. Groen, Niels P. Riksen, Joost H.W. Rutten, Leo A.B. Joosten, Cisca Wijmenga, Alexandra Zhernakova, Mihai G. Netea, Jingyuan Fu, Folkert Kuipers
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108212- (2020)
Summary: Bile acids (BAs) are implicated in the etiology of obesity-related conditions such as non-alcoholic fatty liver disease. Differently structured BA species display variable signaling activities via farnesoid X receptor (FXR) and Takeda G prot
Externí odkaz:
https://doaj.org/article/f5c4cfa383074f0b833a8d715bdad341
Autor:
Emma C. E. Meessen, Fianne L. P. Sips, Hannah M. Eggink, Martijn Koehorst, Johannes A. Romijn, Albert K. Groen, Natal A. W. vanRiel, Maarten R. Soeters
Publikováno v:
Physiological Reports, Vol 8, Iss 5, Pp n/a-n/a (2020)
Abstract Background Bile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein‐coupled receptor 5 (TGR5). The postp
Externí odkaz:
https://doaj.org/article/d73517f54e8a4faba4574698dea6f018