CNTN4 modulates neural elongation through interplay with APP

Autor: Rosemary A. Bamford, Amila Zuko, Madeline Eve, Jan J. Sprengers, Harm Post, Renske L. R. E. Taggenbrock, Dominique Fäβler, Annika Mehr, Owen J. R. Jones, Aurimas Kudzinskas, Josan Gandawijaya, Ulrike C. Müller, Martien J. H. Kas, J. Peter H. Burbach, Asami Oguro-Ando

Publikováno v: Open Biology, Vol 14, Iss 5 (2024)

The neuronal cell adhesion molecule contactin-4 (CNTN4) is genetically associated with autism spectrum disorder (ASD) and other psychiatric disorders. Cntn4-deficient mouse models have previously shown that CNTN4 plays important roles in axon guidanc

Externí odkaz: https://doaj.org/article/ba72db2116e74e9ea015ee3338ab6914

A New Intervention for Implementation of Pharmacogenetics in Psychiatry: A Description of the PSY-PGx Clinical Study

Autor: Teuntje A. D. Pelgrim, Alexandra Philipsen, Allan H. Young, Mario Juruena, Ester Jimenez, Eduard Vieta, Marin Jukić, Erik Van der Eycken, Urs Heilbronner, Ramona Moldovan, Martien J. H. Kas, Raj R. Jagesar, Markus M. Nöthen, Per Hoffmann, Noam Shomron, Laura L. Kilarski, Thérèse van Amelsvoort, Bea Campforts, The PSY-PGx Consortium, Roos van Westrhenen

Publikováno v: Pharmaceuticals, Vol 17, Iss 2, p 151 (2024)

(1) Background Pharmacological treatment for psychiatric disorders has shown to only be effective in about one-third of patients, as it is associated with frequent treatment failure, often because of side effects, and a long process of trial-and-erro

Externí odkaz: https://doaj.org/article/dc7bd9a9f3fa4fd4a6d128297d649d21

Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives

Autor: Fabrizio Grieco, Briana J. Bernstein, Barbara Biemans, Lior Bikovski, C. Joseph Burnett, Jesse D. Cushman, Elsbeth A. van Dam, Sydney A. Fry, Bar Richmond-Hacham, Judith R. Homberg, Martien J. H. Kas, Helmut W. Kessels, Bastijn Koopmans, Michael J. Krashes, Vaishnav Krishnan, Sreemathi Logan, Maarten Loos, Katharine E. McCann, Qendresa Parduzi, Chaim G. Pick, Thomas D. Prevot, Gernot Riedel, Lianne Robinson, Mina Sadighi, August B. Smit, William Sonntag, Reinko F. Roelofs, Ruud A.J. Tegelenbosch, Lucas P.J.J. Noldus

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 15 (2021)

The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue in the field of behavioral neuroscience, where, in spite of efforts to standardize testing and assay protocols, several

Externí odkaz: https://doaj.org/article/e6fe0375a48847e8ab15ebea282102ec

Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models

Autor: Christopher Heise, Jonathan M. Preuss, Jan C. Schroeder, Chiara R. Battaglia, Jonas Kolibius, Rebecca Schmid, Michael R. Kreutz, Martien J. H. Kas, J. Peter H. Burbach, Tobias M. Boeckers

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Autism spectrum disorder (ASD) refers to a large set of neurodevelopmental disorders, which have in common both repetitive behavior and abnormalities in social interactions and communication. Interestingly, most forms of ASD have a strong genetic con

Externí odkaz: https://doaj.org/article/72a105556cba4495be65a13743744b3a

The continued need for animals to advance brain research

Autor: Paul J. Lucassen, Kate Jeffrey, Antonis Asiminas, Heidi M. B. Lesscher, Jos Prickaerts, Gertjan van Dijk, Amanda J. Kiliaan, Daniela Jezova, Carlos P. Fitzsimons, Klaus-Peter Lesch, S. Mechiel Korte, Ulrich L. M. Eisel, Roger A.H. Adan, Tamas Kozicz, Liset Menendez de la Prida, Joanes Grandjean, Marloes J. A. G. Henckens, Corette J. Wierenga, Vladyslav V. Vyazovskiy, Cyriel M. A. Pennartz, Marten P. Smidt, Ype Elgersma, Anne S. Mallien, Sharon M. Kolk, Liya Ma, Kirk Leech, Ingo Willuhn, Jorge F. Mejias, Maximilian Wiesmann, Frank J. Meye, Louk J. M. J. Vanderschuren, Marilise Escobar Burger, Sidarta Ribeiro, August B. Smit, Peter Meerlo, Robbert Havekes, Eddy A. van der Zee, Rixt van der Veen, Regien G. Schoemaker, Massimo Pasqualetti, Andries Kalsbeek, Martien J H Kas, Michael Bader, Joram D. Mul, Bernhard Englitz, Janine I. Rossato, Denovan P. Begg, Tomonori Takeuchi, Markus Wöhr, Antonio Fernández-Ruiz, Bella Williams, Nael Nadif Kasri, Aniko Korosi, Judith R. Homberg, Tom Beckers, Maarten Kamermans, Piotr Popik, Peter Gass, Umberto Olcese, Anna S. Mitchell, Christiane Herden, Jocelien D A Olivier, Monique Wolvekamp, Arjan Blokland, Azahara Oliva González, Natalia Alenina, Lisa Genzel, Wendy Jarrett, Ali-Akbar Salari, Roelof A. Hut, Anne-Marie van Dam, Anita Lüthi, Benno Roozendaal, Steven A. Kushner

Publikováno v: Neuron, 109(15), 2374-2379. Cell Press
Neuron, 109(15), 2374. Cell Press
Neuron, 109, 15, pp. 2374-2379
Neuron, 109, 2374-2379
Homberg, J R, Adan, R A H, Alenina, N, Asiminas, A, Bader, M, Beckers, T, Begg, D P, Blokland, A, Burger, M E, van Dijk, G, Eisel, U L M, Elgersma, Y, Englitz, B, Fernandez-Ruiz, A, Fitzsimons, C P, van Dam, A M, Gass, P, Grandjean, J, Havekes, R, Henckens, M J A G, Herden, C, Hut, R A, Jarrett, W, Jeffrey, K, Jezova, D, Kalsbeek, A, Kamermans, M, Kas, M J, Kasri, N N, Kiliaan, A J, Kolk, S M, Korosi, A, Korte, S M, Kozicz, T, Kushner, S A, Leech, K, Lesch, K P, Lesscher, H, Lucassen, P J, Luthi, A, Ma, L, Mallien, A S, Meerlo, P, Mejias, J F, Meye, F J, Mitchell, A S, Mul, J D, Olcese, U, González, A O, Olivier, J D A, Pasqualetti, M, Pennartz, C M A, Popik, P, Prickaerts, J, de la Prida, L M, Ribeiro, S, Roozendaal, B, Rossato, J I, Salari, A A, Schoemaker, R G, Smit, A B, Vanderschuren, L J M J, Takeuchi, T, van der Veen, R, Smidt, M P, Vyazovskiy, V V, Wiesmann, M, Wierenga, C J, Williams, B, Willuhn, I, Wöhr, M, Wolvekamp, M, van der Zee, E A & Genzel, L 2021, ' The continued need for animals to advance brain research ', Neuron, vol. 109, no. 15, pp. 2374-2379 . https://doi.org/10.1016/j.neuron.2021.07.015
Homberg, J R, Adan, R A H, Alenina, N, Asiminas, A, Bader, M, Beckers, T, Begg, D P, Blokland, A, Burger, M E, van Dijk, G, Eisel, U L M, Elgersma, Y, Englitz, B, Fernandez-Ruiz, A, Fitzsimons, C P, van Dam, A-M, Gass, P, Grandjean, J, Havekes, R, Henckens, M J A G, Herden, C, Hut, R A, Jarrett, W, Jeffrey, K, Jezova, D, Kalsbeek, A, Kamermans, M, Kas, M J, Kasri, N N, Kiliaan, A J, Kolk, S M, Korosi, A, Korte, S M, Kozicz, T, Kushner, S A, Leech, K, Lesch, K-P, Lesscher, H, Lucassen, P J, Luthi, A, Ma, L, Mallien, A S, Meerlo, P, Mejias, J F, Meye, F J, Mitchell, A S, Mul, J D, Olcese, U, González, A O, Olivier, J D A, Pasqualetti, M, Pennartz, C M A, Popik, P, Prickaerts, J, de la Prida, L M, Ribeiro, S, Roozendaal, B, Rossato, J I, Salari, A-A, Schoemaker, R G, Smit, A B, Vanderschuren, L J M J, Takeuchi, T, van der Veen, R, Smidt, M P, Vyazovskiy, V V, Wiesmann, M, Wierenga, C J, Williams, B, Willuhn, I, Wöhr, M, Wolvekamp, M, van der Zee, E A & Genzel, L 2021, ' The continued need for animals to advance brain research ', Neuron, vol. 109, no. 15, pp. 2374-2379 . https://doi.org/10.1016/j.neuron.2021.07.015
Neuron, 109(15), 2374-2379. CELL PRESS
Digital.CSIC. Repositorio Institucional del CSIC
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Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bfd05a12c81a1cd11d8bb8178a0953
https://doi.org/10.1016/j.neuron.2021.07.015