Unsupervised Analysis of Flow Cytometry Data in a Clinical Setting Captures Cell Diversity and Allows Population Discovery

Autor: Petra Baumgaertner, Martial Sankar, Fernanda Herrera, Fabrizio Benedetti, David Barras, Anne-Christine Thierry, Denarda Dangaj, Lana E. Kandalaft, George Coukos, Ioannis Xenarios, Nicolas Guex, Alexandre Harari

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Data obtained with cytometry are increasingly complex and their interrogation impacts the type and quality of knowledge gained. Conventional supervised analyses are limited to pre-defined cell populations and do not exploit the full potential of data

Externí odkaz: https://doaj.org/article/3fce17ae26384f53bbe5b4e3f259cfd1

A systems genetics resource and analysis of sleep regulation in the mouse.

Autor: Shanaz Diessler, Maxime Jan, Yann Emmenegger, Nicolas Guex, Benita Middleton, Debra J Skene, Mark Ibberson, Frederic Burdet, Lou Götz, Marco Pagni, Martial Sankar, Robin Liechti, Charlotte N Hor, Ioannis Xenarios, Paul Franken

Publikováno v: PLoS Biology, Vol 16, Iss 8, p e2005750 (2018)

Sleep is essential for optimal brain functioning and health, but the biological substrates through which sleep delivers these beneficial effects remain largely unknown. We used a systems genetics approach in the BXD genetic reference population (GRP)

Externí odkaz: https://doaj.org/article/07d008a5ea19427ea7fcfbc52c4c49c9

Dissecting the retinoid‐induced differentiation of F9 embryonal stem cells by integrative genomics

Autor: Marco A Mendoza‐Parra, Mannu Walia, Martial Sankar, Hinrich Gronemeyer

Publikováno v: Molecular Systems Biology, Vol 7, Iss 1, Pp 1-16 (2011)

Abstract Retinoic acid (RA) triggers physiological processes by activating heterodimeric transcription factors (TFs) comprising retinoic acid receptor (RARα, β, γ) and retinoid X receptor (RXRα, β, γ). How a single signal induces highly complex

Externí odkaz: https://doaj.org/article/3af9669486af44f588ad355f7c7c0f96

Disturbed local auxin homeostasis enhances cellular anisotropy and reveals alternative wiring of auxin-ethylene crosstalk in Brachypodium distachyon seminal roots.

Autor: David Pacheco-Villalobos, Martial Sankar, Karin Ljung, Christian S Hardtke

Publikováno v: PLoS Genetics, Vol 9, Iss 6, p e1003564 (2013)

Observations gained from model organisms are essential, yet it remains unclear to which degree they are applicable to distant relatives. For example, in the dicotyledon Arabidopsis thaliana (Arabidopsis), auxin biosynthesis via indole-3-pyruvic acid

Externí odkaz: https://doaj.org/article/f3ab52eca0144f6e816841105882091d

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Autor: Gael Boivin, Loïc Steiner, Svenja Groeneveld, Inti Zlobec, Miguel Garcia, Martial Sankar, Nicolas Guex, Alessandra Piersigilli, Ioannis Xenarios, Nadine Zangger, Etienne Meylan, Julien Faget

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2017, 21 (11), pp.3190-3204. ⟨10.1016/j.celrep.2017.11.052⟩
Faget, Julien; Groeneveld, Svenja; Boivin, Gael; Sankar, Martial; Zangger, Nadine; Garcia, Miguel; Guex, Nicolas; Zlobec, Inti; Steiner, Loïc; Piersigilli, Alessandra; Xenarios, Ioannis; Meylan, Etienne (2017). Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer. Cell reports, 21(11), pp. 3190-3204. Cell Press 10.1016/j.celrep.2017.11.052
Cell Reports, Vol 21, Iss 11, Pp 3190-3204 (2017)
Cell reports, vol. 21, no. 11, pp. 3190-3204

International audience; Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a11efff6866a2a47968c11adb259070
https://hal.umontpellier.fr/hal-02430851/document