The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly

Autor: Damien Toullec, Alberto Elías-Villalobos, Céline Faux, Ambre Noly, Gwendaline Lledo, Martial Séveno, Dominique Helmlinger

Publikováno v: Cell Reports, Vol 37, Iss 3, Pp 109867- (2021)

Summary: Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of kinases that control fundamental processes, including cell growth, DNA damage repair, and gene expression. Although their regulation and activities are well characterized,

Externí odkaz: https://doaj.org/article/4e940ddd3a524b149fabe48419968f82

Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

Autor: Inés González-Calvo, Keerthana Iyer, Mélanie Carquin, Anouar Khayachi, Fernando A Giuliani, Séverine M Sigoillot, Jean Vincent, Martial Séveno, Maxime Veleanu, Sylvana Tahraoui, Mélanie Albert, Oana Vigy, Célia Bosso-Lefèvre, Yann Nadjar, Andréa Dumoulin, Antoine Triller, Jean-Louis Bessereau, Laure Rondi-Reig, Philippe Isope, Fekrije Selimi

Publikováno v: eLife, Vol 10 (2021)

Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How proteostasis is controlled independently for each type of synaptic protein in a synapse-specific and activity-dependent manner remains unclear. Here, we sh

Externí odkaz: https://doaj.org/article/01bd3175794d47878ad8b245d0150a1d

Sample Pooling and Inflammation Linked to the False Selection of Biomarkers for Neurodegenerative Diseases in Top–Down Proteomics: A Pilot Study

Autor: Nicolas Molinari, Stéphane Roche, Katell Peoc’h, Laurent Tiers, Martial Séveno, Christophe Hirtz, Sylvain Lehmann

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Proteomic technologies have been recently adapted to the new field of clinical proteomics. The origin of errors and biases has been well-identified in the pre-analytical steps, leading to the measurement of clinical analytes. One possible source of i

Externí odkaz: https://doaj.org/article/1067cc51b7d142e0a3517d4de0a72a40

Proteomic analysis of the promastigote secretome of seven Leishmania species

Autor: Joana Pissarra, Philippe Holzmuller, Julie Pagniez, Oana Vigy, Rachel Bras-Gonçalves, Jean-Loup Lemesre, Martial Séveno, Elodie Petitdidier

Publikováno v: Journal of Proteome Research
Journal of Proteome Research, American Chemical Society, 2022, 21 (1), pp.30-48. ⟨10.1021/acs.jproteome.1c00244⟩
Journal of Proteome Research, American Chemical Society, 2021, ⟨10.1021/acs.jproteome.1c00244⟩

International audience; Leishmaniasis is one of the most impactful parasitic diseases worldwide, endangering the lives of 1 billion people every year. There are 20 different species of Leishmania able to infect humans, causing cutaneous (CL), viscera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e867a68a8788a39e54eb7df0c8fba094
http://agritrop.cirad.fr/601843/

Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells

Autor: Gilles Gadea, Frédéric Allemand, Nikola Arsic, Sylvain de Rossi, Pierre Roux, Marina Kazantseva, Sunali Mehta, Serge Urbach, Andrey V. Kajava, Martial Séveno, Antony W. Braithwaite, Aurélie Fournet, Nathalie Sibille, Etienne Villain, Pau Bernadó, Jean-Christophe Bourdon, Tania L. Slatter

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5463. ⟨10.1038/s41467-021-25550-2⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 2021, 12 (1), pp.5463. ⟨10.1038/s41467-021-25550-2⟩

The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates were observed in cancer cells and tumour biopsies. The Δ133p53β agg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dd3be7548c1f6dca40c6cc2f8d3044
https://hal.archives-ouvertes.fr/hal-03346748