Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas

Autor: Isabel Weigand, Cristina L. Ronchi, Marthe Rizk-Rabin, Guido Di Dalmazi, Vanessa Wild, Kerstin Bathon, Beatrice Rubin, Davide Calebiro, Felix Beuschlein, Jérôme Bertherat, Martin Fassnacht, Silviu Sbiera

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30–40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA

Externí odkaz: https://doaj.org/article/a7dfc728130647c9871d28bac6b0b73e

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

Autor: Sébastien Gaujoux, Constanze Hantel, Pierre Launay, Stéphane Bonnet, Karine Perlemoine, Lucile Lefèvre, Marine Guillaud-Bataille, Felix Beuschlein, Frédérique Tissier, Jérôme Bertherat, Marthe Rizk-Rabin, Bruno Ragazzon

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55743 (2013)

ContextAdrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activ

Externí odkaz: https://doaj.org/article/e8baa0d2cca04cffbfe551e33e213bea

Supplementary Table 2 from Inactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGFβ-Stimulated Apoptosis in Adrenocortical Cells

Autor: Jérôme Bertherat, Antoine Martinez, Karine Perlemoine, Hélène Fierrard, Lionel Groussin, Guillaume Assie, Marthe Rizk-Rabin, Laure Cazabat, Bruno Ragazzon

Supplementary Table 2 from Inactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGFβ-Stimulated Apoptosis in Adrenocortical Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6cd06af20ea38ed454cb62d98a61c0
https://doi.org/10.1158/0008-5472.22381706.v1

Cullin 3 targets the tumor suppressor gene ARMC5 for ubiquitination and degradation

Autor: Anna Vaczlavik, Eric Clauser, Isadora Pontes Cavalcante, Maria Candida Barisson Villares Fragoso, Jérôme Bertherat, Ludivine Drougat, Marthe Rizk-Rabin, Claudimara Ferini Pacicco Lotfi, Christopher Ribes, Bruno Ragazzon, Karine Perlemoine

Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, BioScientifica, 2020, 27 (4), pp.221-230. ⟨10.1530/ERC-19-0502⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

ARMC5 (Armadillo repeat containing 5 gene) was identified as a new tumor suppressor gene responsible for hereditary adrenocortical tumors and meningiomas. ARMC5 is ubiquitously expressed and encodes a protein which contains a N-terminal Armadillo rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da7e67e7455c5c98598129c893bfaec
https://doi.org/10.1530/erc-19-0502

Genomic classification of benign adrenocortical lesions

Autor: Bertrand Dousset, Simon Faillot, Anna Vaczlavik, Jean Guibourdenche, Lionel Groussin, Mathilde Sibony, Fideline Bonnet-Serrano, Stéphanie Espiard, Amandine Septier, Mario Neou, Ludivine Drougat, Marthe Rizk-Rabin, Bruno Ragazzon, Guillaume Assié, Simon Garinet, Thomas Foulonneau, Anne Jouinot, Windy Rondof, Rossella Libé, Karine Hecale-Perlemoine, Aurélien de Reyniès, Jérôme Bertherat

Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, BioScientifica, 2020, ⟨10.1530/ERC-20-0128⟩

Benign adrenal tumors cover a spectrum of lesions with distinct morphology and steroid secretion. Current classification is empirical. Beyond a few driver mutations, pathophysiology is not well understood. Here, a pangenomic characterization of benig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee80574d1ec6a22da6d1142eb8ff701
https://pubmed.ncbi.nlm.nih.gov/33151900