CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance

Autor: Masaki Takasugi, Naoko Ohtani, Kazuaki Takemura, Stephan Emmrich, Frances T. Zakusilo, Yuya Yoshida, Nobuyuki Kutsukake, John N. Mariani, Martha S. Windrem, Devin Chandler-Militello, Steven A. Goldman, Junko Satoh, Shinji Ito, Andrei Seluanov, Vera Gorbunova

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113130- (2023)

Summary: The naked mole rat (NMR) is the longest-lived rodent, resistant to multiple age-related diseases including neurodegeneration. However, the mechanisms underlying the NMR’s resistance to neurodegenerative diseases remain elusive. Here, we is

Externí odkaz: https://doaj.org/article/04f80f73b8014e2e83d91863b9a4d47c

Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling

Autor: Zhengshan Liu, Mikhail Osipovitch, Abdellatif Benraiss, Nguyen P.T. Huynh, Rossana Foti, Janna Bates, Devin Chandler-Militello, Robert L. Findling, Paul J. Tesar, Maiken Nedergaard, Martha S. Windrem, Steven A. Goldman

Publikováno v: Cell Reports, Vol 27, Iss 13, Pp 3832-3843.e6 (2019)

Summary: Astrocytic differentiation is developmentally impaired in patients with childhood-onset schizophrenia (SCZ). To determine why, we used genetic gain- and loss-of-function studies to establish the contributions of differentially expressed tran

Externí odkaz: https://doaj.org/article/16ab12112b63407da85af17b18749977

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease

Autor: Martha S. Windrem, Mikhail Osipovitch, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman, Carlos Benitez Villanueva, John N. Mariani, Adam Cornwell

Publikováno v: Benraiss, A, Mariani, J N, Osipovitch, M, Cornwell, A, Windrem, M S, Villanueva, C B, Chandler-Militello, D & Goldman, S A 2021, ' Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease ', Cell Reports, vol. 36, no. 1, 109308 . https://doi.org/10.1016/j.celrep.2021.109308

Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b206d15dbfad3f84e0ea8f4d27df81c8
https://curis.ku.dk/portal/da/publications/cellintrinsic-glial-pathology-is-conserved-across-human-and-murine-models-of-huntingtons-disease(c3ca9d6a-32a3-4218-8682-ce9366a925d3).html

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain

Autor: Devin Chandler-Militello, Yuan Lu, Lisa Zou, Martha S. Windrem, Nicholas J. Kuypers, Steven A. Goldman, John N. Mariani, Steven J. Schanz

Publikováno v: Windrem, M S, Schanz, S J, Zou, L, Chandler-Militello, D, Kuypers, N J, Nedergaard, M, Lu, Y, Mariani, J N & Goldman, S A 2020, ' Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain ', Cell Reports, vol. 31, no. 7, 107658 . https://doi.org/10.1016/j.celrep.2020.107658
Cell Reports, Vol 31, Iss 7, Pp-(2020)
Cell Rep

Summary: Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival. Yet, it has been unclear whether implanted hGPCs are similarly able to remyelinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447227b4287c5d66d45c51e5673fd1fb
https://curis.ku.dk/ws/files/242660575/Human_Glial_Progenitor_Cells_Effectively_Remyelinate_the_Demyelinated_Adult_Brain.pdf

Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease

Autor: David H. Rowitch, Martha S. Windrem, M. Joana Osorio, Marius Wernig, Steven A. Goldman, Paul J. Tesar

Publikováno v: Stem Cells. 35:311-315

Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder caused by mutation in the proteolipid protein-1 (PLP1) gene, which encodes the proteolipid protein of myelinating oligodendroglia. PMD exhibits phenotypic variability that reflects its consid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0d8a1861b8e5fcae979c8bf54aef867
https://doi.org/10.1002/stem.2530