AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer

Autor: Agnete S.T. Engelsen, Katarzyna Wnuk-Lipinska, Sebastien Bougnaud, Fanny A. Pelissier Vatter, Crina Tiron, René Villadsen, Masaru Miyano, Maria L. Lotsberg, Noëlly Madeleine, Pouda Panahandeh, Sushil Dhakal, Tuan Zea Tan, Stacey D’mello Peters, Sturla Grøndal, Sura M. Aziz, Silje Nord, Lars Herfindal, Martha R. Stampfer, Therese Sørlie, Rolf A. Brekken, Oddbjørn Straume, Nils Halberg, Gro Gausdal, Jean Paul Thiery, Lars A. Akslen, Ole W. Petersen, Mark A. LaBarge, James B. Lorens

Publikováno v: iScience, Vol 23, Iss 11, Pp 101649- (2020)

Summary: The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of stemness traits in c

Externí odkaz: https://doaj.org/article/5755d332fcae4e12a5f7287f52b4495c

Abstracts from the 3rd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects

Autor: Athel Cornish-Bowden, David Rasnick, Henry H. Heng, Steven Horne, Batoul Abdallah, Guo Liu, Christine J. Ye, Mathew Bloomfield, Mark D. Vincent, C. Marcelo Aldaz, Jenny Karlsson, Anders Valind, Caroline Jansson, David Gisselsson, Jennifer A. Marshall Graves, Aleksei A. Stepanenko, Svitlana V. Andreieva, Kateryna V. Korets, Dmytro O. Mykytenko, Nataliya L. Huleyuk, Vladimir P. Baklaushev, Oksana A. Kovaleva, Vladimir P. Chekhonin, Yegor S. Vassetzky, Stanislav S. Avdieiev, Bjorn Bakker, Aaron S. Taudt, Mirjam E. Belderbos, David Porubsky, Diana C. J. Spierings, Tristan V. de Jong, Nancy Halsema, Hinke G. Kazemier, Karina Hoekstra-Wakker, Allan Bradley, Eveline S. J. M. de Bont, Anke van den Berg, Victor Guryev, Peter M. Lansdorp, Maria Colomé Tatché, Floris Foijer, Thomas Liehr, Nicolaas C. Baudoin, Joshua M. Nicholson, Kimberly Soto, Isabel Quintanilla, Jordi Camps, Daniela Cimini, M. Dürrbaum, N. Donnelly, V. Passerini, C. Kruse, B. Habermann, Z. Storchová, Daniele Mandrioli, Fiorella Belpoggi, Ellen K Silbergeld, Melissa J Perry, Rolf I. Skotheim, Marthe Løvf, Bjarne Johannessen, Andreas M. Hoff, Sen Zhao, Jonas M. SveeStrømme, Anita Sveen, Ragnhild A. Lothe, R. Hehlmann, A. Voskanyan, A. Fabarius, Alfred Böcking, Stefan Biesterfeld, Leonid Berynskyy, Christof Börgermann, Rainer Engers, Josef Dietz, A. Fritz, N. Sehgal, J. Vecerova, B. Stojkovicz, H. Ding, N. Page, C. Tye, S. Bhattacharya, J. Xu, G. Stein, J. Stein, R. Berezney, Xue Gong, Sarah Grasedieck, Julian Swoboda, Frank G. Rücker, Lars Bullinger, Jonathan R. Pollack, Fani-Marlen Roumelioti, Maria Chiourea, Christina Raftopoulou, Sarantis Gagos, Peter Duesberg, Mat Bloomfield, Sunyoung Hwang, Hans Tobias Gustafsson, Ciara O’Sullivan, Aracelli Acevedo-Colina, Xinhe Huang, Christian Klose, Andrej Schevchenko, Robert C. Dickson, Paola Cavaliere, Noah Dephoure, Eduardo M. Torres, Martha R. Stampfer, Lukas Vrba, Mark A. LaBarge, Bernard Futscher, James C. Garbe, Yi-Hong Zhou, Andrew L. Trinh, Michelle Digman

Publikováno v: Molecular Cytogenetics, Vol 10, Iss S2, Pp 77-94 (2017)

Externí odkaz: https://doaj.org/article/b6866d4289674f288bf6c946e8f882e4

Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance

Autor: Tiina A. Jokela, Agnete S. T. Engelsen, Agata Rybicka, Fanny A. Pelissier Vatter, James C. Garbe, Masaru Miyano, Crina Tiron, Dan Ferariu, Lars A. Akslen, Martha R. Stampfer, James B. Lorens, Mark A. LaBarge

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 6 (2018)

The existence of rare cancer cells that sporadically acquire drug-tolerance through epigenetic mechanisms is proposed as one mechanism that drives cancer therapy failure. Here we provide evidence that specific microenvironments impose non-sporadic ex

Externí odkaz: https://doaj.org/article/8bc0a51cad1e414ba45a716580f1c03a

Supplementary Figure 3 from Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia

Autor: Mark A. LaBarge, Martha R. Stampfer, Alexander D. Borowsky, Ole W. Petersen, Morag Park, Rene Villadsen, Diana E. Guo, Agla J. Fridriksdottir, Klara Sputova, Fanny A. Pelissier, Francois Pepin, James C. Garbe

PDF file - 2.3MB, Lineage marker distributions in cultured and uncultured HMEC. Sevenparameter flow cytometry analyses of 4th passage HMEC strains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66741ffade0f5d0bd48514624f9d479c
https://doi.org/10.1158/0008-5472.22393472.v1

Data from Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization

Autor: Bernard W. Futscher, Martha R. Stampfer, James C. Garbe, Taylor J. Jensen, Petr Novak

The timing and progression of DNA methylation changes during carcinogenesis are not completely understood. To develop a timeline of aberrant DNA methylation events during malignant transformation, we analyzed genome-wide DNA methylation patterns in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1b0788f6d4af83ba2d70a2d50198331
https://doi.org/10.1158/0008-5472.c.6499224.v1