Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Martha N. Simon"'
Autor:
Julie L. Hodgkinson, Paula C. A. da Fonseca, Ariel J. Blocker, Susan M. Lea, David Stabat, Martha N. Simon, Ashley Horsley, Joseph S. Wall, Steven Johnson, Edward P. Morris
Publikováno v:
Nature Structural & Molecular Biology. 16:477-485
Gram-negative bacteria use type III secretion systems (T3SSs) to pass virulence factors into host cells, making them potential therapeutic targets to combat bacterial infection. A new EM study of the needle complex from the Shigella T3SS reveals 12-f
Autor:
Joseph S. Wall, Alasdair C. Steven, Raimon Sabaté, Anindito Sen, Sven J. Saupe, Ulrich Baxa, Martha N. Simon
Publikováno v:
Journal of Biological Chemistry. 282:5545-5550
Fungal prions are infectious filamentous polymers of proteins that are soluble in uninfected cells. In its prion form, the HET-s protein of Podospora anserina participates in a fungal self/non-self recognition phenomenon called heterokaryon incompati
Autor:
Marc C. Johnson, Stephen D. Fuller, Martha N. Simon, Volker M. Vogt, John A. G. Briggs, Ingolf Gross, Hans-Georg Kräusslich
Publikováno v:
Nature Structural & Molecular Biology. 11:672-675
The major structural components of HIV-1 are encoded as a single polyprotein, Gag, which is sufficient for virus particle assembly. Initially, Gag forms an approximately spherical shell underlying the membrane of the immature particle. After proteoly
Autor:
Martha N. Simon, Melvin P. Tucker, Marcus Jones, Joseph S. Wall, Garry Rumbles, Shi You Ding, Jovan M. Nedeljković, Michael E. Himmel
Publikováno v:
Nano Letters. 3:1581-1585
We report the assembly of quantum dots using an approach that attempts to capitalize on the self-assembling properties of naturally occurring proteins. Colloidal quantum dots made of cadmium selenide core and a zinc sulfide shell, (CdSe)ZnS, were inc
Autor:
Kimberly L. Taylor, Reed B. Wickner, Ulrich Baxa, Martha N. Simon, Naiqian Cheng, Alasdair C. Steven, Joseph S. Wall
Publikováno v:
Journal of Biological Chemistry. 278:43717-43727
The [URE3] prion is an inactive, self-propagating, filamentous form of the Ure2 protein, a regulator of nitrogen catabolism in yeast. The N-terminal "prion" domain of Ure2p determines its in vivo prion properties and in vitro amyloid-forming ability.
Autor:
Hilal A. Lashuel, Thomas Walz, Richard Nowak, Peter T. Lansbury, Joseph S. Wall, Martha N. Simon, Benjamin M. Petre
Publikováno v:
Journal of Molecular Biology. 322:1089-1102
Two mutations in the alpha-synuclein gene (A30P and A53T) have been linked to autosomal dominant early-onset Parkinson's disease (PD). Both mutations promote the formation of transient protofibrils (prefibrillar oligomers), suggesting that protofibri
Autor:
Elisabeth Scharer, Michal Jarnik, Donnie S. Bundman, Dennis R. Roop, Pierre A. de Viragh, Alasdair C. Steven, Martha N. Simon
Publikováno v:
Journal of Investigative Dermatology. 118:102-109
The cornified cell envelope, a lipoprotein layer that assembles at the surface of terminally differentiated keratinocytes, is a resilient structure on account of covalent crosslinking of its constituent proteins, principally loricrin, which accounts
Publikováno v:
Journal of Biological Chemistry. 276:11049-11054
Vaccination with heat shock protein gp96-antigenic peptide complexes produces a powerful specific immune response against cancers and infectious diseases in some experimental animal models, and gp96-peptide complexes are now being tested in human cli
Publikováno v:
Journal of Biological Chemistry. 276:11743-11753
FtsZ is a bacterial homolog of tubulin that is essential for prokaryotic cytokinesis. In vitro, GTP induces FtsZ to assemble into straight, 5-nm-wide polymers. Here we show that the polymerization of these FtsZ filaments most closely resembles noncoo
Publikováno v:
Proceedings of the National Academy of Sciences. 97:1530-1535
The minichromosome maintenance (MCM) proteins are essential for DNA replication in eukaryotes. Thus far, all eukaryotes have been shown to contain six highly related MCMs that apparently function together in DNA replication. Sequencing of the entire