Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Martha M. Zarou"'
Autor:
Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Supporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully ex
Externí odkaz:
https://doaj.org/article/6aaf61afdaf341b3a2d9f753c4561387
Autor:
Amy Dawson, Martha M. Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E. M. Hopcroft, Mary T. Scott, Pablo Baquero, Karen Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B. Coffelt, Ong Sin Tiong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Macrophages are fundamental cells of the innate immune system that support normal haematopoiesis and play roles in both anti-cancer immunity and tumour progression. Here we use a chimeric mouse model of chronic myeloid leukaemia (CML) and hu
Externí odkaz:
https://doaj.org/article/8f93c354e91945c2be6407a9da014cb7
Autor:
Kevin M. Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M. Zarou, Kiron Roy, Ryan Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf, Eric R. Kalkman, Mary T. Scott, Karen Dunn, David Sumpton, Alison M. Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic ste
Externí odkaz:
https://doaj.org/article/f6923fc9708841a5bf7e890a6863e86a
Autor:
Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Amy Dawson, Angela Ianniciello, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Supporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully exploited i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1873c90c97261d3b5163da6d13c04023
https://doi.org/10.1101/2022.12.21.521404
https://doi.org/10.1101/2022.12.21.521404
Autor:
G. Vignir Helgason, Eric R. Kalkman, Angela Ianniciello, Mhairi Copland, Colin Nixon, Karen Dunn, Alison M. Michie, Zuzana Brabcova, Martin Ambler, Barbara Saxty, Amy Dawson, Kevin M. Rattigan, Martha M. Zarou, David Vetrie, Mary T. Scott
Publikováno v:
Sci Transl Med
Inhibition of autophagy has been proposed as a potential therapy for individuals with cancer. However, current lysosomotropic autophagy inhibitors have demonstrated limited efficacy in clinical trials. Therefore, validation of novel specific autophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f458d69df5677c1b31b29e24f3c470a1
https://eprints.gla.ac.uk/252673/1/252673.pdf
https://eprints.gla.ac.uk/252673/1/252673.pdf
Autor:
Alexei Vazquez, Kevin M. Rattigan, Zuzana Brabcova, David Sumpton, Martha M. Zarou, Amy Dawson, Vignir Helgason
Publikováno v:
Blood. 138:2543-2543
Metabolic rewiring is an important hallmark of cancer. The folate metabolism pathway, also known as one-carbon (1C) metabolism, allows for transfer of 1C units through folate intermediates for biosynthetic processes, including precursors for DNA synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c6eb498de953a3c2628c5e059258b43
https://doi.org/10.1182/blood-2021-149664
https://doi.org/10.1182/blood-2021-149664