Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Martha L. Bulyk"'
Autor:
Kian Hong Kock, Patrick K. Kimes, Stephen S. Gisselbrecht, Sachi Inukai, Sabrina K. Phanor, James T. Anderson, Gayatri Ramakrishnan, Colin H. Lipper, Dongyuan Song, Jesse V. Kurland, Julia M. Rogers, Raehoon Jeong, Stephen C. Blacklow, Rafael A. Irizarry, Martha L. Bulyk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with the largest number of disease-associated mutations in the Human
Externí odkaz:
https://doaj.org/article/fb03d33422b540199802faeaf082a440
Autor:
Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht, Martha L. Bulyk, Lori L. O'Brien
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/4f3047bac88542cc9b27e1ea55de683f
Autor:
Dustin C. Becht, Brianna J. Klein, Akinori Kanai, Suk Min Jang, Khan L. Cox, Bing-Rui Zhou, Sabrina K. Phanor, Yi Zhang, Ruo-Wen Chen, Christopher C. Ebmeier, Catherine Lachance, Maxime Galloy, Amelie Fradet-Turcotte, Martha L. Bulyk, Yawen Bai, Michael G. Poirier, Jacques Côté, Akihiko Yokoyama, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH
Externí odkaz:
https://doaj.org/article/a2ad2ef5ddc546e58f71dca700b8f668
Autor:
Colin T. Waters, Stephen S. Gisselbrecht, Yuliya A. Sytnikova, Tiziana M. Cafarelli, David E. Hill, Martha L. Bulyk
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Understanding the contributions of transcription factor DNA binding sites to transcriptional enhancers is a significant challenge. We developed Quantitative enhancer-FACS-Seq for highly parallel quantification of enhancer activities from a g
Externí odkaz:
https://doaj.org/article/f4bb68481a69441cb27f3a3d910c8ac7
Autor:
Akira Terakawa, Yanhui Hu, Toshiya Kokaji, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Yifei Pan, Yunfan Bai, Andrey A. Parkhitko, Xiaochun Ni, John M. Asara, Martha L. Bulyk, Norbert Perrimon, Shinya Kuroda
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104231- (2022)
Summary: Insulin signaling promotes anabolic metabolism to regulate cell growth through multi-omic interactions. To obtain a comprehensive view of the cellular responses to insulin, we constructed a trans-omic network of insulin action in Drosophila
Externí odkaz:
https://doaj.org/article/2f11eb9ab7944adc856e74542facdc46
Autor:
Emily G. Kaye, Matthew Booker, Jesse V. Kurland, Alexander E. Conicella, Nicolas L. Fawzi, Martha L. Bulyk, Michael Y. Tolstorukov, Erica Larschan
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3227-3239 (2018)
Summary: Little is known about how variation in sequence composition alters transcription factor occupancy to precisely recruit large transcription complexes. A key model for understanding how transcription complexes are targeted is the Drosophila do
Externí odkaz:
https://doaj.org/article/571743602286407cb10426777cb6913f
Autor:
Leila Shokri, Sachi Inukai, Antonina Hafner, Kathryn Weinand, Korneel Hens, Anastasia Vedenko, Stephen S. Gisselbrecht, Riccardo Dainese, Johannes Bischof, Edy Furger, Jean-Daniel Feuz, Konrad Basler, Bart Deplancke, Martha L. Bulyk
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 955-970.e7 (2019)
Summary: Combinatorial interactions among transcription factors (TFs) play essential roles in generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) assays on nearly all sequence-specific Drosophila TFs, we iden
Externí odkaz:
https://doaj.org/article/9e3550215eb148d5a27340a7e617b017
Autor:
Bo Zhao, Luis A. Barrera, Ina Ersing, Bradford Willox, Stefanie C.S. Schmidt, Hannah Greenfeld, Hufeng Zhou, Sarah B. Mollo, Tommy T. Shi, Kaoru Takasaki, Sizun Jiang, Ellen Cahir-McFarland, Manolis Kellis, Martha L. Bulyk, Elliott Kieff, Benjamin E. Gewurz
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1595-1606 (2014)
The nuclear factor κB (NF-κΒ) subunits RelA, RelB, cRel, p50, and p52 are each critical for B cell development and function. To systematically characterize their responses to canonical and noncanonical NF-κB pathway activity, we performed chromat
Externí odkaz:
https://doaj.org/article/36415eb4404c419da9e5fcac60a1a559
Publikováno v:
Cell Reports, Vol 3, Iss 4, Pp 1093-1104 (2013)
DNA sequence is a major determinant of the binding specificity of transcription factors (TFs) for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with highly similar DNA binding motifs but distinct in vivo target
Externí odkaz:
https://doaj.org/article/864f1cc5096244bc86c32389c76a2208
Autor:
Jun Qi, A. Thomas Look, Kimberly Stegmaier, Brian J. Abraham, Martha L. Bulyk, Ernst Schönbrunn, John Easton, Olaf Wiest, Taylor R. Quinn, Melissa J. Bikowitz, Antonio R. Perez-Atayde, Amanda L. Robichaud, Amy Saur Conway, Ken Morita, Logan H. Sigua, Paul M.C. Park, Lily Maxham, Maya Mundada, Ying Shao, Anand G. Patel, Stephanie Nance, Noha A.M. Shendy, Luca Mariani, Neekesh V. Dharia, Deyao Li, Mark W. Zimmerman, Virangika K. Wimalasena, Tingjian Wang, Adam D. Durbin
Supplementary Data from EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700913e64764f6e6c15c2df8eb0c5d30
https://doi.org/10.1158/2159-8290.22541228
https://doi.org/10.1158/2159-8290.22541228
