Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Martha L Bulyk"'
Autor:
Ignacio L Ibarra, Vikram S Ratnu, Lucia Gordillo, In‐Young Hwang, Luca Mariani, Kathryn Weinand, Henrik M Hammarén, Jennifer Heck, Martha L Bulyk, Mikhail M Savitski, Judith B Zaugg, Kyung‐Min Noh
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 8, Pp n/a-n/a (2022)
Abstract Neuronal stimulation induced by the brain‐derived neurotrophic factor (BDNF) triggers gene expression, which is crucial for neuronal survival, differentiation, synaptic plasticity, memory formation, and neurocognitive health. However, its
Externí odkaz:
https://doaj.org/article/3980541312b745348c31389d5c19f1aa
Autor:
Qinwen Liu, Pinar Onal, Rhea R Datta, Julia M Rogers, Urs Schmidt-Ott, Martha L Bulyk, Stephen Small, Joseph W Thornton
Publikováno v:
eLife, Vol 7 (2018)
The ancient mechanisms that caused developmental gene regulatory networks to diversify among distantly related taxa are not well understood. Here we use ancestral protein reconstruction, biochemical experiments, and developmental assays of transgenic
Externí odkaz:
https://doaj.org/article/cd4ba06be696424196a71f5fdaa8b314
Autor:
Guray Kuzu, Emily G Kaye, Jessica Chery, Trevor Siggers, Lin Yang, Jason R Dobson, Sonia Boor, Jacob Bliss, Wei Liu, Gerwald Jogl, Remo Rohs, Nadia D Singh, Martha L Bulyk, Michael Y Tolstorukov, Erica Larschan
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006120 (2016)
Dosage compensation is an essential process that equalizes transcript levels of X-linked genes between sexes by forming a domain of coordinated gene expression. Throughout the evolution of Diptera, many different X-chromosomes acquired the ability to
Externí odkaz:
https://doaj.org/article/059126ee109c4fffbd67b17d9cc244b2
Autor:
Brian W Busser, Stephen S Gisselbrecht, Leila Shokri, Terese R Tansey, Caitlin E Gamble, Martha L Bulyk, Alan M Michelson
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69385 (2013)
Homeodomain (HD) proteins are a large family of evolutionarily conserved transcription factors (TFs) having diverse developmental functions, often acting within the same cell types, yet many members of this family paradoxically recognize similar DNA
Externí odkaz:
https://doaj.org/article/ae3415d4afba4ec79cbd98334d7707cd
Autor:
William R Swindell, Andrew Johnston, Liou Sun, Xianying Xing, Gary J Fisher, Martha L Bulyk, James T Elder, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33204 (2012)
Skin aging is associated with intrinsic processes that compromise the structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but u
Externí odkaz:
https://doaj.org/article/dce52a4941c64ae7b5dc422e4747c04b
Autor:
Dolrudee Jumlongras, Salil A Lachke, Daniel J O'Connell, Anton Aboukhalil, Xiao Li, Sung E Choe, Joshua W K Ho, Annick Turbe-Doan, Erin A Robertson, Bjorn R Olsen, Martha L Bulyk, Brad A Amendt, Richard L Maas
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38568 (2012)
To elucidate the transcriptional regulation of Bmp4 expression during organogenesis, we used phylogenetic footprinting and transgenic reporter analyses to identify Bmp4 cis-regulatory modules (CRMs). These analyses identified a regulatory region loca
Externí odkaz:
https://doaj.org/article/08e5f2f2b31c43439d3dcdafd28aa674
Autor:
Cristina Del Bianco, Anastasia Vedenko, Sung Hee Choi, Michael F Berger, Leila Shokri, Martha L Bulyk, Stephen C Blacklow
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15034 (2010)
Canonical Notch signaling is initiated when ligand binding induces proteolytic release of the intracellular part of Notch (ICN) from the cell membrane. ICN then travels into the nucleus where it drives the assembly of a transcriptional activation com
Externí odkaz:
https://doaj.org/article/c65213337b5b4aadb3bdc839822ca71e
Inferring condition‐specific transcription factor function from DNA binding and gene expression data
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Externí odkaz:
https://doaj.org/article/c88bce4045f54f5c91b37a9cc67309c8
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5242 (2009)
Calorie restriction (CR) is the only intervention known to extend lifespan in a wide range of organisms, including mammals. However, the mechanisms by which it regulates mammalian aging remain largely unknown, and the involvement of the TOR and sirtu
Externí odkaz:
https://doaj.org/article/63bbbaa07fc442069b1cb2ef182d2d55
Autor:
Anthony A Philippakis, Brian W Busser, Stephen S Gisselbrecht, Fangxue Sherry He, Beatriz Estrada, Alan M Michelson, Martha L Bulyk
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 5, p e53 (2006)
While combinatorial models of transcriptional regulation can be inferred for metazoan systems from a priori biological knowledge, validation requires extensive and time-consuming experimental work. Thus, there is a need for computational methods that
Externí odkaz:
https://doaj.org/article/15a5874a0a4a422197c9547317d96a8f